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Evaluating the raftophilicity of membrane proteins in a patterned model membrane

Research Project

Project/Area Number 26291031
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Biophysics
Research InstitutionKobe University

Principal Investigator

Morigaki Kenichi  神戸大学, バイオシグナル総合研究センター, 准教授 (10358179)

Co-Investigator(Kenkyū-buntansha) 林 文夫  神戸大学, 理学(系)研究科(研究院), 名誉教授 (80093524)
鈴木 健一  京都大学, 学内共同利用施設等, 准教授 (50423059)
笠井 倫志  京都大学, 再生医科学研究所, 助教 (20447949)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywords生体膜 / 膜タンパク質 / 脂質ラフト / 人工膜 / ロドプシン光受容体 / 受容体 / ロドプシン / GPCR
Outline of Final Research Achievements

Lipid rafts in the cell membrane are believed to affect various membrane functions, including the signaling by G protein coupled receptors (GPCRs). However, the regulatory roles of lipid rafts on membrane functions are still poorly understood, partially owing to the lack of the methods to quantitatively evaluate the affinity of membrane proteins to lipid raft (raftophilicity). We developed a new methodology to gauge the raftophilicity of membrane proteins by using a patterned model membrane that has patterned liquid ordered (Lo) and liquid disordered (Ld) bilayers. We reconstituted membrane proteins including rhodopsin (Rh) and determined their raftophilicities. We found that the raftophilicity of Rh was heightened upon photo-activation, suggesting the functional roles of lipid rafts. Patterned model membrane offers a robust and scalable platform for systematically and quantitatively studying the functional roles of lipid rafts in biological membranes including retinal disc membranes.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (58 results)

All 2017 2016 2015 2014 Other

All Journal Article (14 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 14 results,  Open Access: 4 results,  Acknowledgement Compliant: 5 results) Presentation (35 results) (of which Int'l Joint Research: 9 results,  Invited: 29 results) Book (5 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) Funded Workshop (1 results)

  • [Journal Article] Investigation of raft dynamics by single-molecule observation of ganglioside probes2017

    • Author(s)
      鈴木健一
    • Journal Title

      生化学

      Volume: 89 Issue: 1 Pages: 121-125

    • DOI

      10.14952/SEIKAGAKU.2017.890121

    • NAID

      40021119840

    • ISSN
      0037-1017
    • Year and Date
      2017-02-25
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the Prod1 membrane anchor in newt limb regeneration2017

    • Author(s)
      Nomura, K., Tanimoto, Y., Hayashi, F., Harada, E., Shan, X.-Y., Shionyu, M., Hijikata, A., Shirai, T., Morigaki, K., Shimamoto, K.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 56 Issue: 1 Pages: 270-274

    • DOI

      10.1002/anie.201609703

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs2017

    • Author(s)
      Masanao Kinoshita, Kenichi GN Suzuki, Nobuaki Matsumori, Misa Takada, Hikaru Ano, Kenichi Morigaki, Mitsuhiro Abe, Asami Makino, Toshihide Kobayashi, Koichiro M Hirosawa, Takahiro K Fujiwara, Akihiro Kusumi, Michio Murata
    • Journal Title

      J Cell Biol

      Volume: 未定 Issue: 4 Pages: 1183-1204

    • DOI

      10.1083/jcb.201607086

    • NAID

      120005998045

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nanometric gap structure with fluid lipid bilayer for the selective transport and detection of biological molecules2016

    • Author(s)
      Ando, K., Tanabe, M., Morigaki, K.
    • Journal Title

      Langmuir

      Volume: 32 Issue: 31 Pages: 7958-7964

    • DOI

      10.1021/acs.langmuir.6b01405

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Raft-based interactions of gangliosides with a GPI-anchored receptor2016

    • Author(s)
      N. Komura, K. G. N. Suzuki, H. Ando, M. Konishi, M. Koikeda, A. Imamura, R. Chadda, T. K. Fujiwara, H. Tsuboi, R. Sheng, W. Cho, K. Furukawa, K. Furukawa, Y. Yamauchi, H. Ishida, A. Kusumi (Co-Corresponding Author), and M. Kiso
    • Journal Title

      Nat. Chem. Biol.

      Volume: in press Issue: 6 Pages: 402-410

    • DOI

      10.1038/nchembio.2059

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Confined diffusion of transmembrane proteins and lipids induced by the same actin meshwork lining the plasma membrane2016

    • Author(s)
      T. K. Fujiwara, Iwasawa, K., Kalay, Z., Tsunoyama, T. A. Y. Watanabe, Y. M. Umemura, H. Murakoshi, K. G. N. Suzuki, Y. L., Nemoto, N. Morone, A. Kusumi
    • Journal Title

      Mol. Cell Biol.

      Volume: 27 Issue: 7 Pages: 1101-1119

    • DOI

      10.1091/mbc.e15-04-0186

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Single-molecule imaging of signal transduction via GPI-anchored receptors2016

    • Author(s)
      K. G. N. Suzuki
    • Journal Title

      Methods Mol. Biol.

      Volume: 1376 Pages: 229-238

    • DOI

      10.1007/978-1-4939-3170-5_19

    • ISBN
      9781493931699, 9781493931705
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Evaluating the raftophilicity of rhodopsin photoreceptor in a patterned model membrane2015

    • Author(s)
      Tanimoto, Y., Okada, K., *Hayashi, F., Morigaki, K.
    • Journal Title

      Biophysical Journal

      Volume: 109 Issue: 11 Pages: 2307-2316

    • DOI

      10.1016/j.bpj.2015.10.015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New insights into the organization of the plasma membrane and its role in signal transduction2015

    • Author(s)
      Suzuki, K. G. N.
    • Journal Title

      Int. Rev. Cell Mol. Biol.

      Volume: in press Pages: 67-96

    • DOI

      10.1016/bs.ircmb.2015.02.004

    • ISBN
      9780128022801
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Micropatterned model membrane with quantitatively controlled separation of lipid phases2015

    • Author(s)
      Okada, F., Morigaki, K.
    • Journal Title

      RSC Adv.

      Volume: 5 Issue: 2 Pages: 1507-1513

    • DOI

      10.1039/c4ra09981h

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Amyloid aggregation and deposition of human islet amyloid polypeptide at membrane interfaces2014

    • Author(s)
      Kenji Sasahara, Kenichi Morigaki, Kyoko Shinya
    • Journal Title

      FEBS Journal

      Volume: 印刷中 Issue: 11 Pages: 2597-2612

    • DOI

      10.1111/febs.12807

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrafast diffusion of a fiuorescent cholesterol analog in compartmentalized plasma membranes.2014

    • Author(s)
      Hiramoto-Yamaki N, Tanaka KA, Suzuki KG, Hirosawa KM, Miyahara MS, Kalay Z, Tanaka K, Kasai RS, Kusumi A, Fujiwara TK.
    • Journal Title

      Traffic

      Volume: 15(In Press)(5月号) Issue: 6 Pages: 583-612

    • DOI

      10.1111/tra.12163

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tracking single molecules at work in living cells2014

    • Author(s)
      A. Kusumi, T. A. Tsunoyama, K. M. Hirosawa, R. S. Kasai, and T. K. Fujiwara
    • Journal Title

      Nature Chemical Biology

      Volume: 10 Issue: 7 Pages: 524-532

    • DOI

      10.1038/nchembio.1558

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-molecule imaging revealed dynamic GPCR dimerization2014

    • Author(s)
      R. S. Kasai and A. Kusumi
    • Journal Title

      Curr Opin Cell Biol.

      Volume: 27 Pages: 78-86

    • DOI

      10.1016/j.ceb.2013.11.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Nanogap-junction with a fluid lipid bilayer for selective biosensing2017

    • Author(s)
      Kenichi Morigaki
    • Organizer
      8th International Workshop on Nanostructures & Nanoelectronics
    • Place of Presentation
      Tohoku University
    • Year and Date
      2017-03-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子観察によるガングリオシドのクラスター形成機構とEGF受容体活性制御機構の解明2017

    • Author(s)
      鈴木健一
    • Organizer
      新学術領域研究「神経糖鎖生物学」最終班会議
    • Place of Presentation
      JPタワー名古屋、名古屋
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高精度1分子観察で初めて明らかになった細胞膜構造とシグナル伝達機構2017

    • Author(s)
      鈴木健一
    • Organizer
      第3回医薬獣連携研究会プログラム
    • Place of Presentation
      岐阜薬科大学、岐阜市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Transient GPCR dimers trigger basal signals as revealed by single-molecule imaging2017

    • Author(s)
      Kasai RS
    • Organizer
      Gordon Research Conference, Molecular Pharmacology, “GPCRs: From Single Molecules to New Forms of Treatment”
    • Place of Presentation
      Il Ciocco, Italy
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluating the raftophilicity of rhodopsin photoreceptor in a patterned model membrane2016

    • Author(s)
      Morigaki, K., Tanimoto, Y., Hayashi, F.
    • Organizer
      251st American Chemical Society National Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-03-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Raft organization and function revealed by single-molecule imaging of ganglioside probes2016

    • Author(s)
      Kenichi G. N. Suzuki
    • Organizer
      The 3rd International Symposium on Glyco-Neuroscience
    • Place of Presentation
      淡路国際会議場
    • Year and Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unraveling of raft Organization and function by single-molecule imaging of new ganglioside probes2016

    • Author(s)
      Kenichi G. N. Suzuki
    • Organizer
      The 21st iCeMS International Symposium
    • Place of Presentation
      Kyoto University
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation mechanisms of EGF receptor activity by gangliosides as revealed by single-molecule imaging2016

    • Author(s)
      Kenichi G. N. Suzuki
    • Organizer
      The 8th Asian Community for Glycoscience and Glycotechnology Annual Conference
    • Place of Presentation
      Jiangnan University, Wuxi, China
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子イメージングにより明らかになったガングリオシドの糖鎖相互作用によるEGF受容体活性制御機構2016

    • Author(s)
      鈴木健一
    • Organizer
      日本プロテオーム学会2016年大会
    • Place of Presentation
      北里大学、東京都
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Dynamic dimer formation of G-protein coupled receptor in the live plasma membrane: An approach by using single molecule observation2016

    • Author(s)
      笠井倫志、楠見明弘
    • Organizer
      第54 回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] valuating the raftophilicity of rhodopsin in a patterned model membrane2015

    • Author(s)
      Tanimoto, Yasushi; Hayashi, Fumio; Morigaki, Kenichi
    • Organizer
      2015 International Chemical Congress of Pacific Basin Societies (Pacifichem 2015)
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] パターン化脂質膜とナノ空間を融合した新規人工生体膜の創出2015

    • Author(s)
      森垣憲一,安藤公二,田邊真志
    • Organizer
      第 35回表面科学学術講演会
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ガングリオシド糖鎖相互作用が誘起するラフトの組織化と機能の1分子観察による解明2015

    • Author(s)
      鈴木健一
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Unraveling raft organization and function by GPI-anchored receptors and gangliosides2015

    • Author(s)
      Kenichi G. N. Suzuki
    • Organizer
      Super-Resolution Seminar
    • Place of Presentation
      inStem, Bangalore, India
    • Year and Date
      2015-11-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Micro-/ nano-compartments between substrate-supported model membrane and silicone elastomer2015

    • Author(s)
      Morigaki, K.
    • Organizer
      TethMem 2015
    • Place of Presentation
      Nanyan University, Singapore
    • Year and Date
      2015-11-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] パターン化モデル生体膜を用いた、光シグナル伝達に関わる膜タンパク質の脂質ラフト親和性解析2015

    • Author(s)
      谷本泰士、小嶋佐妃子、森垣憲一、林文夫
    • Organizer
      第53 回 日本生物物理学会 年会
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] ロドプシンはラフト親和性の短寿命ナノドメインを形成しながら拡散している2015

    • Author(s)
      林 文夫、齋藤 夏美、谷本 泰士、森垣 憲一、妹尾 圭司
    • Organizer
      第53 回 日本生物物理学会 年会
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Constitutive signaling without ligation characteristic with GPCRs is triggered by transient GPCR dimers2015

    • Author(s)
      Kasai RS, Kusumi A
    • Organizer
      第53 回日本生物物理学会
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Patterned lipid bilayer on solid substrate as a versatile model system of the biological membrane2015

    • Author(s)
      Morigaki, K.
    • Organizer
      Biological Research Centre, Hungarian Academy of Science
    • Place of Presentation
      Szeged, Hungary
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 1分子イメージングにより明らかになったラフト組織化と機能のための最初のステップ2015

    • Author(s)
      鈴木健一
    • Organizer
      日本顕微鏡学会第71回学術講演会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Nanometric gap structure between substrate-supported model membrane and silicone elastomer2015

    • Author(s)
      Kenichi Morigaki
    • Organizer
      249th ACS National Meeting and Exposition
    • Place of Presentation
      Denver Convention Center, Denver CO, USA
    • Year and Date
      2015-03-22 – 2015-03-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The very first step for raft organization and function, revealed by single-molecule imaging2015

    • Author(s)
      K. G. N. Suzuki
    • Organizer
      The 15th International Membrane Research Forum
    • Place of Presentation
      京都大学
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Transient GPCR dimers trigger basal signals as revealed by single-molecule imaging2015

    • Author(s)
      Kasai R.S.
    • Organizer
      The 18th iCeMS International Symposium and The 15th International Membrane Research Forum Featuring Meso-Scale Molecular Complexes and Domains and Synaptic Membranes
    • Place of Presentation
      京都大学
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Unraveling of raft organization and function by single-molecule imaging of new ganglioside probes2014

    • Author(s)
      K. G. N. Suzuki
    • Organizer
      Symposium on the cellular meso-scale structures and their functions
    • Place of Presentation
      京都大学
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dynamic monomer-dimer equilibrium of G-protein-coupled receptors as detected by single-molecule tracking2014

    • Author(s)
      Kasai R.S.
    • Organizer
      Symposium on the cellular meso-scale structures and their functions
    • Place of Presentation
      京都大学
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Single-molecule imaging of new ganglioside probes revealed the very first steps for raft organization and function2014

    • Author(s)
      K. G. N. Suzuki
    • Organizer
      SFG-JSCR Joint Meeting
    • Place of Presentation
      Honolulu, HA, USA
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ガングリオシドの糖鎖間相互作用により誘起されるラフト構造と機能の解明2014

    • Author(s)
      鈴木健一
    • Organizer
      第87回日本生化学会大会シンポジウム
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dynamic monomer-dimer equilibrium of G-protein-coupled receptors as detected by single-molecule tracking2014

    • Author(s)
      Kasai R.S. and Kusumi A.
    • Organizer
      ComBio2014
    • Place of Presentation
      キャンベラ、オーストラリア
    • Year and Date
      2014-09-29 – 2014-10-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] パターン化人工膜を用いた膜タンパク質のラフト親和性解析2014

    • Author(s)
      森垣憲一
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Single-molecule tracking of GPI-anchored proteins and gangliosides revealed raft organization2014

    • Author(s)
      鈴木健一
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dimers are the key trigger for the GPCR’s basic signaling without ligation2014

    • Author(s)
      Kasai R.S.
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] モデル生体膜を用いたロドプシン光受容体の脂質ラフト親和性解析2014

    • Author(s)
      谷本 泰士, 森垣 憲一, 林 文夫
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ガングリオシド蛍光プローブの1分子追跡によるラフト構造と機能の解明2014

    • Author(s)
      鈴木健一
    • Organizer
      第33回日本糖質学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-08-10 – 2014-08-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ガングリオシドプローブの1分子追跡によるラフト組織化と昨日の解明2014

    • Author(s)
      鈴木健一
    • Organizer
      第66回日本細胞生物学会年会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The very first steps for raft formation and function, revealed by single-molecule imaging2014

    • Author(s)
      K. G. N. Suzuki
    • Organizer
      Bordeaux-Kyoto Symposium
    • Place of Presentation
      University of Bordeaux
    • Year and Date
      2014-05-05 – 2014-05-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Book] 医学のあゆみ GPCR 研究の最前線2016

    • Author(s)
      笠井 倫志
    • Total Pages
      6
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] Glycoscience: Biology and Medicine2015

    • Author(s)
      Kenichi G. N. Suzuki
    • Total Pages
      8
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 生物模倣技術と新材料・新製品開発への応用2014

    • Author(s)
      森垣憲一
    • Total Pages
      7
    • Publisher
      技術情報協会
    • Related Report
      2014 Annual Research Report
  • [Book] Glycoscience: Biology and Medicine2014

    • Author(s)
      K. G. N. Suzuki
    • Total Pages
      8
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 生体の科学 [増大特集] 生命動態システム科学2014

    • Author(s)
      笠井倫志
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Remarks] 神戸大学バイオシグナル総合研究センター環境物質科学研究室

    • URL

      http://www.research.kobe-u.ac.jp/rceg-nowstone/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 神戸大学環境物質科学研究室

    • URL

      http://www.research.kobe-u.ac.jp/rceg-nowstone/index.html

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] ナノギャップ構造型基板2015

    • Inventor(s)
      森垣憲一
    • Industrial Property Rights Holder
      国立大学法人神戸大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-001194
    • Filing Date
      2015-01-06
    • Related Report
      2014 Annual Research Report
  • [Funded Workshop] Unraveling the regulation mechanisms of signal transduction in nano- and meso-scale domains in cell membranes2016

    • Place of Presentation
      Tsukuba Convention Center
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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