Structural basis for cytoplasmic dynein regulation
| Project/Area Number |
26291034
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Osaka University (2015-2017)
Hosei University (2014) |
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Principal Investigator |
Kon Takahide 大阪大学, 大学院理学研究科, 教授 (30332620)
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| Co-Investigator(Renkei-kenkyūsha) |
KURISU Genji 大阪大学, 蛋白質研究所, 教授 (90294131)
FURUTA Kenya 独立行政法人情報通信研究機構, 未来ICT研究所, 主任研究員 (40571831)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 分子モーター / 構造生物学 / ナノマシン / 酵素反応 / モータータンパク質 / 細胞内物質輸送 / タンパク質科学 / 分子機械 / 生物物理 / 蛋白質 / 細胞内輸送 |
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| Outline of Final Research Achievements |
Dynein is a huge microtubule-based motor complex that powers a wide variety of biological processes within eukaryotic cells, including cell division, cell migration, and the intracellular trafficking. However, the regulatory mechanism of dynein, which is critical for exerting these diverse cellular functions, still remains unclear. Here, we have performed electron microscopic analysis of dynein inactivated complex. This study provides a structural basis for understanding the mechanism underlying dynein-based motility.
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Report
(5 results)
Research Products
(25 results)
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[Journal Article] Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and propermorphology of inner dynein arms2017
Author(s)
Yamamoto, R., Obbineni, J.M., Alford, L.M., Ide, T., Owa, M., Hwang, J., Kon, T., Inaba, K., James, N., King, S.M., Ishikawa, T., Sale, W.S., Dutcher, S.K.
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Journal Title
PLoS Genet.
Volume: 13
Issue: 9
Pages: e1006996-e1006996
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules.2015
Author(s)
Imai, H., Shima, T., Sutoh, K., Walker, M.L., Knight, P.J., Kon, T., Burgess, S.A.
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Journal Title
Nature Commun.
Volume: 6
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A flipped ion pair at the dynein-microtubule interface is critical for dynein motility and ATPase activation2015
Author(s)
Uchimura, S., Fujii, T., Takazaki, H., Ayukawa, R., Nishikawa, Y., Minoura, I., Hachikubo, Y., Kurisu, G., Sutoh, K., Kon, T., Namba, K., Muto, E.
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Journal Title
J. Cell Biol.
Volume: 208
Issue: 2
Pages: 211-222
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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