Analysis of activation mechanism and physiological function of ARL family small GTPases
| Project/Area Number |
26291038
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Meiji Pharmaceutical University (2015-2017)
The University of Tokyo (2014) |
|---|
Principal Investigator |
Kontani Kenji 明治薬科大学, 薬学部, 教授 (30302615)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
荒木 信 明治薬科大学, 薬学部, 助教 (20552904)
福山 征光 東京大学, 薬学研究科(研究院), 助教 (20422389)
齋藤 康太 東京大学, 薬学研究科(研究院), 助教 (60549632)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Katada Toshiaki 東京大学, 大学院薬学系研究科, 教授 (10088859)
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
|
|---|
| Keywords | 低分子量Gタンパク質 / リソソーム / エンドサイトーシス / 一次繊毛 / マウス / 胚発生 / 卵黄嚢内胚葉 / ARF/ARLファミリー / BMP / 低分子量Ｇタンパク質 / 細胞内物質輸送 / オルガネラ / 細胞内オルガネラ / メンブラントラフィック / 繊毛性疾患 / ARF/ARL GTPase |
|---|
| Outline of Final Research Achievements |
In this study, we clarified that the ARL family small GTPase ARL8b is necessary for normal growth and brain development of mouse embryos. ARL8b was found to be important for lysosomal degradation of maternally derived protein components incorporated in the visceral yolk sac endoderm, and the functional deficiency of ARL8b in the visceral yolk sac endoderm caused a reduction in the amount of amino acids in the embryo proper and a failure of embryonic growth. We also found that ARL8b may be involved in the regulation of BMP signaling in embryonic brain development.
|
Report
(5 results)
Research Products
(19 results)
-
-
[Journal Article] Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos2017
Author(s)
Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T and Kontani K
-
Journal Title
J Cell Sci
Volume: 130
Issue: 20
Pages: 3568-3577
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells2017
Author(s)
Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K and Miyake K
-
Journal Title
Nat Commun
Volume: 8
Issue: 1
Pages: 1592-1592
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Variegated RHOA mutations in adult T-cell leukemia/lymphoma2016
Author(s)
Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, (9名), Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S
-
Journal Title
Blood
Volume: 127
Issue: 5
Pages: 596-604
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
