| Project/Area Number |
26291038
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Meiji Pharmaceutical University (2015-2017)
The University of Tokyo (2014) |
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Principal Investigator |
Kontani Kenji 明治薬科大学, 薬学部, 教授 (30302615)
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| Co-Investigator(Kenkyū-buntansha) |
荒木 信 明治薬科大学, 薬学部, 助教 (20552904)
福山 征光 東京大学, 薬学研究科(研究院), 助教 (20422389)
齋藤 康太 東京大学, 薬学研究科(研究院), 助教 (60549632)
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| Co-Investigator(Renkei-kenkyūsha) |
Katada Toshiaki 東京大学, 大学院薬学系研究科, 教授 (10088859)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 低分子量Gタンパク質 / リソソーム / エンドサイトーシス / 一次繊毛 / マウス / 胚発生 / 卵黄嚢内胚葉 / ARF/ARLファミリー / BMP / 低分子量Ｇタンパク質 / 細胞内物質輸送 / オルガネラ / 細胞内オルガネラ / メンブラントラフィック / 繊毛性疾患 / ARF/ARL GTPase |
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| Outline of Final Research Achievements |
In this study, we clarified that the ARL family small GTPase ARL8b is necessary for normal growth and brain development of mouse embryos. ARL8b was found to be important for lysosomal degradation of maternally derived protein components incorporated in the visceral yolk sac endoderm, and the functional deficiency of ARL8b in the visceral yolk sac endoderm caused a reduction in the amount of amino acids in the embryo proper and a failure of embryonic growth. We also found that ARL8b may be involved in the regulation of BMP signaling in embryonic brain development.
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