| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
The surface of our body is covered by the cellular sheet which is designated the epithelium. Epithelial cells are arranged like cobblestones and adhere with each other, thereby the leak of water-soluble substances through the intercellular space is restricted. In this study, we investigated the function of angulin family proteins constituting tricellular contacts, where the vertices of three epithelial cells meet. The mice lacking one of the angulin family proteins showed healing loss caused by the degeneration of hair cells in the inner ear.
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