The molecular mechanism underlying the epithelial barrier formation by tricellular tight junctions
| Project/Area Number |
26291043
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | National Institute for Physiological Sciences (2015-2016)
Kobe University (2014) |
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Principal Investigator |
Furuse Mikio 生理学研究所, 生体機能調節研究領域, 教授 (90281089)
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| Co-Investigator(Kenkyū-buntansha) |
泉 裕士 生理学研究所, 大脳皮質機能研究系, 准教授 (10373268)
菅原 太一 生理学研究所, 生体機能調節研究領域, 助教 (30758412)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 上皮細胞 / 細胞接着 / タイトジャンクション / 上皮バリア機能 / 遺伝性難聴 / アンギュリン / トリセルリン / MDCK細胞 / トリセルラージャンクション / 上皮 |
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| Outline of Final Research Achievements |
The surface of our body is covered by the cellular sheet which is designated the epithelium. Epithelial cells are arranged like cobblestones and adhere with each other, thereby the leak of water-soluble substances through the intercellular space is restricted. In this study, we investigated the function of angulin family proteins constituting tricellular contacts, where the vertices of three epithelial cells meet. The mice lacking one of the angulin family proteins showed healing loss caused by the degeneration of hair cells in the inner ear.
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Report
(4 results)
Research Products
(20 results)
