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Regulation and physiological role of mitochondrial fusion and fission in mammals

Research Project

Project/Area Number 26291044
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Cell biology
Research InstitutionKurume University

Principal Investigator

Naotada Ishihara  久留米大学, 分子生命科学研究所, 教授 (10325516)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywordsミトコンドリア / オルガネラ / 膜融合 / 膜分裂 / GTPase / 細胞・組織 / 生体分子 / 膜形成
Outline of Final Research Achievements

Mitochondrial dynamics by frequent fusion and fission have important roles in various cellular signaling processes and pathophysiology in vivo. However, the molecular mechanism that regulates mitochondrial fusion and fission in mammalian cells are not well understood. We analyzed molecular mechanism to regulate mitochondrial morphology in mammalian cells, by balanced mitochondrial fusion and fission. We also found important roles of mitochondrial fission in formation of cardiomyocytes during neonatal heart development, and maintenance of oocyte quality.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (47 results)

All 2017 2016 2015 2014 Other

All Journal Article (20 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 13 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (25 results) (of which Int'l Joint Research: 2 results,  Invited: 12 results) Remarks (2 results)

  • [Journal Article] PARL paves the way to apoptosis.2017

    • Author(s)
      N. Ishihara and K. Mihara.
    • Journal Title

      Nat. Cell Biol.

      Volume: 19 Issue: 4 Pages: 263-265

    • DOI

      10.1038/ncb3504

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] ミトコンドリア形態変化の生理的意義2017

    • Author(s)
      伴 匡人、尾上 健太、石原 直忠
    • Journal Title

      医学のあゆみ

      Volume: 260 Pages: 18-23

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] D-Glutamate is metabolized in the heart mitochondria.2016

    • Author(s)
      M. Ariyoshi, M. Katane, K. Hamase, Y. Miyoshi, M. Nakane, A. Hoshino, Y. Okawa, Y. Mita, S. Kaimoto, M. Uchihashi, K. Fukai, K. Ono, S. Tateishi, D. Hato, R. Yamanaka, S. Honda, Y. Fushimura, E. Iwai-Kanai, N. Ishihara, M. Mita, H. Homma, and S. Matoba.
    • Journal Title

      Sci. Rep.

      Volume: 7 Issue: 1 Pages: 43911-43911

    • DOI

      10.1038/srep43911

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.2016

    • Author(s)
      Saita S, Ishihara T, Maeda M, Iemura S, Natsume T, Mihara K, Ishihara N.
    • Journal Title

      Genes Cells

      Volume: 21(5) Issue: 5 Pages: 408-424

    • DOI

      10.1111/gtc.12351

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.2016

    • Author(s)
      S. Saita, T. Ishihara, M.Maeda, S. Iemura, T. Natsume, K. Mihara and N. Ishihara.
    • Journal Title

      Genes Cells.

      Volume: 21 Issue: 1 Pages: 408-424

    • DOI

      10.1038/srep28331

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons.2016

    • Author(s)
      B. Oettinghaus, J. Schulz, L. Restelli, C. Savoia, A. Schmidt, K. Schmitt, A. Grimm, L. Morè, J. Hench, M. Tolnay, A. Eckert, P. D'Adamo, P. Franken, N. Ishihara, K. Mihara, J. Bischofberger, L. Scorrano, S. Frank.
    • Journal Title

      Cell Death Differ.

      Volume: 23 Issue: 1 Pages: 18-28

    • DOI

      10.1038/cdd.2015.39

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ミトコンドリアのダイナミクスとその生理機能2016

    • Author(s)
      太田 あずさ、伴 匡人、石原 直忠
    • Journal Title

      脳21

      Volume: 19 Pages: 211-216

    • Related Report
      2016 Annual Research Report
  • [Journal Article] COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1.2015

    • Author(s)
      Ban-Ishihara R, Tomohiro-Takamiya S, Tani M, Baudier J, Ishihara N, and Kuge O
    • Journal Title

      FEBS Lett

      Volume: 589 Issue: 20PartB Pages: 3126-3132

    • DOI

      10.1016/j.febslet.2015.08.039

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.2015

    • Author(s)
      Wang L, Ishihara T, Ibayashi Y, Tatsushima K, Setoyama D, Hanada Y, Takeichi Y, Sakamoto S, Yokota S, Mihara K, Kang D, Ishihara N, Takayanagi R, Nomura M
    • Journal Title

      Diabetologia

      Volume: 58 Issue: 10 Pages: 2371-2380

    • DOI

      10.1007/s00125-015-3704-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death.2015

    • Author(s)
      A. Jahani-Asl, E. Huang, I. Irrcher, J. Rashidian, N. Ishihara, DC. Lagace, RS. Slack, DS. Park.
    • Journal Title

      Hum. Mol. Genet.

      Volume: 24 Issue: 16 Pages: 4573-4583

    • DOI

      10.1093/hmg/ddv188

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Physiological roles of mitochondrial fission in cultured cells and mouse development.2015

    • Author(s)
      Ishihara T, Kohno H, Ishihara N.
    • Journal Title

      Ann N Y Acad Sci.

      Volume: 1350 Issue: 1 Pages: 77-81

    • DOI

      10.1111/nyas.12848

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリア分裂の生理機能とその破綻2015

    • Author(s)
      石原 直忠
    • Journal Title

      医学のあゆみ

      Volume: 254 Pages: 433-439

    • Related Report
      2015 Annual Research Report
  • [Journal Article] ミトコンドリアのダイナミクスとその役割2015

    • Author(s)
      石原 直忠
    • Journal Title

      数研出版 サイエンスネット

      Volume: 52 Pages: 2-5

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Dynamics of mtDNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.2015

    • Author(s)
      T. Ishihara, R. Ban-Ishihara, M. Maeda, Y. Matsunaga, A. Ichimura, S. Kyogoku, H. Aoki, S. Katadam K. Nakada, M. Nomura, N. Mizushima, K. Mihara, and N. Ishihara
    • Journal Title

      Molecular Cell Biology

      Volume: 35 Issue: 1 Pages: 211-223

    • DOI

      10.1128/mcb.01054-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division.2015

    • Author(s)
      Arasaki K., Shimizu H., Mogari H., Nishida N., Hirota N., Furuno A., Kudo Y., Baba M., Baba N., Cheng J., Fujimoto T., Ishihara N., Ortiz-Sandoval C., Barlow L., Raturi A., Dohmae N., Wakana Y., Inoue H., Tani K., Dacks J., Simmen T., Tagaya M.
    • Journal Title

      Dev. Cell.

      Volume: 32 Pages: 304-317

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリア分裂因子Drp1は細胞小器官のダイナミックな再編成を通して卵子の質を維持する2015

    • Author(s)
      宇田川 理、石原 直忠
    • Journal Title

      細胞工学

      Volume: 34 Pages: 82-83

    • Related Report
      2014 Annual Research Report
  • [Journal Article] ミトコンドリアの融合と分裂:その意義と制御機構2015

    • Author(s)
      伴 匡人、後藤 雅史、石原 直忠
    • Journal Title

      化学と生物

      Volume: 53 Pages: 27-33

    • NAID

      130005113831

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons.2015

    • Author(s)
      Oettinghaus B., Schulz J., Restelli L., Savoia C., Schmidt A., Schmitt K., Grimm A., Morè L., Hench J., Tolnay M., Eckert A., D'Adamo P., Franken P., Ishihara N., Mihara K., Bischofberger J., Scorrano L. Frank S.
    • Journal Title

      Cell Death Differ.

      Volume: 未

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial Fission Factor Drp1 Maintains Oocyte Quality via Dynamic Rearrangement of Multiple Organelles2014

    • Author(s)
      O Udagawa, T Ishihara, M Maeda, Y Matsunaga, S Tsukamoto, N Kawano, K Miyado, H Shitara, S Yokota, M Nomura, K Mihara, N Mizushima, N Ishihara
    • Journal Title

      Current Biology

      Volume: 24 Issue: 20 Pages: 2451-2458

    • DOI

      10.1016/j.cub.2014.08.060

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細胞と組織におけるミトコンドリアの形態制御機構と役割2014

    • Author(s)
      石原 孝也、石原 直忠
    • Journal Title

      生体の科学

      Volume: 65 Pages: 299-303

    • Related Report
      2014 Annual Research Report
  • [Presentation] Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin2017

    • Author(s)
      Tadato Ban and Naotada Ishihara
    • Organizer
      International Symposium on Autophagy
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ミトコンドリアの膜とゲノムの協調的な形態制御2016

    • Author(s)
      伴匡人、石原孝也、太田あずさ、石原直忠
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 成長期の骨格筋におけるDrp1の機能2016

    • Author(s)
      一村 紋佳、石原 孝也、石原 直忠
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミトコンドリアの膜とmtDNAのダイナミクスを制御する因子の探索2016

    • Author(s)
      石原 孝也、石原 直忠
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] OPA1プロテオリポソームによるミトコンドリア内膜融合機構の解明2016

    • Author(s)
      伴匡人、石原直忠
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミトコンドリアのGTPaseタンパク質による融合と分裂の制御2016

    • Author(s)
      石原直忠、河野裕翔、太田あずさ、伴匡人、石原孝也
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] ミトコンドリアの融合と分裂のバランス制御とその分子機構2016

    • Author(s)
      石原直忠、伴匡人、河野裕翔、石原孝也
    • Organizer
      第68回日本細胞生物学会大会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 個体内でのミトコンドリアの融合と分裂の意義2016

    • Author(s)
      石原 直忠
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアの動的な形態制御とその意義2016

    • Author(s)
      石原 直忠
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      郡山
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアの膜とDNAの協調的かつ動的な制御機構2015

    • Author(s)
      石原 孝也、石原 直忠
    • Organizer
      BMB2015(第38回日本分子生物学会、第88回日本生化学会)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミトコンドリアは生きている2015

    • Author(s)
      石原 直忠
    • Organizer
      第15回日本ミトコンドリア学会年会 市民公開講座
    • Place of Presentation
      福井
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] オーバービュー(基礎科学)2015

    • Author(s)
      石原 直忠
    • Organizer
      第15回日本ミトコンドリア学会年会
    • Place of Presentation
      福井
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Roles of mitochondrial dynamics in mammalian development/differentiation. Molecular Mitochondria2015

    • Author(s)
      Naotada Ishihara
    • Organizer
      Joint Seminar of Young Finnish‐Japanese Mitoscientists
    • Place of Presentation
      Helsinki
    • Year and Date
      2015-10-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ミトコンドリアの動的な形態制御2015

    • Author(s)
      石原 直忠
    • Organizer
      第45回(2015)新潟神経学夏期セミナー
    • Place of Presentation
      新潟
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 哺乳動物細胞におけるミトコンドリアの融合と分裂の制御2015

    • Author(s)
      石原 直忠
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリア核様体ダイナミクスの分子機構の解明2015

    • Author(s)
      石原(伴)玲子,石原 直忠
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミトコンドリアの融合と分裂の生理的意2015

    • Author(s)
      石原 直忠
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] リコンビナントOPA1Lによるミトコンドリア内膜融合機構の解明2014

    • Author(s)
      伴匡人、石原直忠
    • Organizer
      第14回日本ミトコンドリア学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミトコンドリア核様体ダイナミクスの分子機構の解析2014

    • Author(s)
      石原玲子、石原直忠
    • Organizer
      第14回日本ミトコンドリア学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] mtDNA分布制御を介した心筋細胞成熟におけるミトコンドリア分裂の役割2014

    • Author(s)
      石原孝也、石原玲子、一村紋佳、三原勝芳、石原直忠
    • Organizer
      第14回日本ミトコンドリア学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-03 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Physiological roles of mitochondrial fission in cultured cells and in mice development2014

    • Author(s)
      Naotada Ishihara, Reiko Ban-Ishihara, Takaya Ishihara, Tadato Ban
    • Organizer
      11th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM 2014)
    • Place of Presentation
      Taipei
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアのダイナミクスによる細胞機能制御2014

    • Author(s)
      石原直忠、伴匡人、石原孝也、石原(伴)玲子、前田 真希
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] OPA1プロテオリポソームによるミトコンドリア内膜融合機構の解明2014

    • Author(s)
      伴匡人、石原直忠
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dynamics of mtDNA nucleoid regulated by mitochondrial fission contributes to cristae reformation, release of cytochrome c, and heart development2014

    • Author(s)
      Takaya Ishihara, Reiko Ban-Ishihara and Naotada Ishihara
    • Organizer
      EuroMit 2014
    • Place of Presentation
      Tampere, Finland
    • Year and Date
      2014-06-15 – 2014-06-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 哺乳動物細胞におけるミトコンドリアの融合と分裂の制御2014

    • Author(s)
      細田將太郎、石原孝也、石原(伴)玲子、伴匡人、石原直忠
    • Organizer
      第66回日本細胞生物学会
    • Place of Presentation
      奈良
    • Year and Date
      2014-06-12
    • Related Report
      2014 Annual Research Report
  • [Remarks] 久留米大学 分子生命科学研究所 高分子化学研究部門

    • URL

      http://mitochondria.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 久留米大学 分子生命科学研究所

    • URL

      http://www.lsi.kurume-u.ac.jp/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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