| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Mitochondrial dynamics by frequent fusion and fission have important roles in various cellular signaling processes and pathophysiology in vivo. However, the molecular mechanism that regulates mitochondrial fusion and fission in mammalian cells are not well understood. We analyzed molecular mechanism to regulate mitochondrial morphology in mammalian cells, by balanced mitochondrial fusion and fission. We also found important roles of mitochondrial fission in formation of cardiomyocytes during neonatal heart development, and maintenance of oocyte quality.
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