| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
|---|
| Outline of Final Research Achievements |
The mammalian cortex has expanded during evolution and its primordium consists with radial glial (RG) cells as neural progenitors. RG cells have long processes stretching between apical and basal surface of the cortical primordium. We would like to understand molecular mechanisms for long-distance transportation within the RG cell, and focused on an RNA-binding protein, i.e., fragile X mental retardation protein (FMRP) , coded by Fmr1 gene. We performed RIP-ChIP analyses and found candidate mRNAs as targets of FMRP, and examined expression profiles of the candidate genes. Immunohistochemical analyses showed decreased expression of some of the candidate genes at the protein level, suggesting a possibility that these transcripts can be transported by FMRP.
|
