Analysis of molecular mechanism for initial left-right axis formation in the node of mouse embryos
| Project/Area Number |
26291051
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyushu University |
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Principal Investigator |
Chikara Meno 九州大学, 医学研究院, 教授 (20311764)
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| Co-Investigator(Renkei-kenkyūsha) |
OKI Shinya 九州大学, 医学研究院, 助教 (90452713)
KITAJIMA Keiko 九州大学, 医学研究院, 助教 (00332784)
OHKAWA Yasuyuki 九州大学, 生体防御医学研究所, 教授 (80448430)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | 左右軸 / データベース / ChIP-seq / 遺伝子発現 / データーベース / 胚発生 / 左右軸形成 / 発生・分化 / ChIPシークエンス / 次世代シークエンス / ソフトウェア |
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| Outline of Final Research Achievements |
The node appears in early mouse embryo and functions as a generator of left-right axis. Since this function depends on spatiotemporal information and interaction with adjacent tissues, associating the node with embryonic system is an important view to understand left-right axis formation. In this project, we analyzed the gene regulation by Nodal signal which is required for node and left-right axis formation, and also examined the expression mechanism for Wnt3a which is required for the expression on left-right axis related genes around the node. Additionally, we developed SraTailor and ChIP-Atlas which were utilized in above project. ChIP-Atlas is an integrated database by which proteins-DNA interactions based on all ChIP-seq data are displayed on IGV genome browser.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Chd5 Regulates MuERV-L/MERVL Expression in Mouse Embryonic Stem Cells Via H3K27me3 Modification and Histone H3.1/H3.2.2015
Author(s)
Hayashi M, Maehara K, Harada A, Semba Y, Kudo K, Takahashi H, Oki S, Meno C, Ichiyanagi K, Akashi K, Ohkawa Y.
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Journal Title
J Cell Biochem
Volume: 117
Issue: 3
Pages: 780-792
DOI
Related Report
Peer Reviewed / Open Access
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