| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
The node appears in early mouse embryo and functions as a generator of left-right axis. Since this function depends on spatiotemporal information and interaction with adjacent tissues, associating the node with embryonic system is an important view to understand left-right axis formation. In this project, we analyzed the gene regulation by Nodal signal which is required for node and left-right axis formation, and also examined the expression mechanism for Wnt3a which is required for the expression on left-right axis related genes around the node. Additionally, we developed SraTailor and ChIP-Atlas which were utilized in above project. ChIP-Atlas is an integrated database by which proteins-DNA interactions based on all ChIP-seq data are displayed on IGV genome browser.
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