| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
This proposal aims at understanding the mechanism of signal discrimination and further unraveling the function of orphan EPFL peptides during Arabidopsis development. Using the promoter swapping approach, we learned that the sub-family of EPF/EPFL peptides have shared and specific activities. We further revealed that EPFL2-ERECTA-family ligand-receptor pair is required for leaf margin morphogenesis. Furthermore, we demonstrated that a negative feedback circuitry between auxin and EPFL2 signaling promotes leaf teeth growth by maintaining the auxin maxima throughout the dynamic process of leaf expansion. During secondary growth, ERECTA-family ensure the timing of wood tissue expansion, a process mediated by GA. Our work reveals that EPF/EPFL-ERECTA-family ligand-receptor pairs control specific developmental programs through interaction with phytohormones, and that restricted expression of peptide ligands in part contribute to signal specificity.
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