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Mechanisms of cell cycle regulation at G2/M and its diverse roles in plant development

Research Project

Project/Area Number 26291058
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Plant molecular biology/Plant physiology
Research InstitutionNagoya University

Principal Investigator

ITO Masaki  名古屋大学, 生命農学研究科, 准教授 (10242851)

Co-Investigator(Kenkyū-buntansha) 町田 泰則  名古屋大学, 理学(系)研究科(研究院), 教授 (80175596)
Co-Investigator(Renkei-kenkyūsha) SUZUKI Takamasa  中部大学, 応用生物学部, 講師 (50535797)
KUWATA Keiko  名古屋大学, トランスフォーマティブ生命分子研究所, 特任助教 (70624352)
NAKAMICHI Norihito  名古屋大学, トランスフォーマティブ生命分子研究所, 特任助教 (90513440)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords細胞周期 / 細胞増殖 / 転写制御 / タンパク質分解 / RNA代謝 / 環境ストレス / 細胞分裂 / 植物 / 核内倍加 / G2/M期制御 / 非対称分裂
Outline of Final Research Achievements

For controlling plant organ growth in changing environment, it is important to properly regulate proliferation of component cells in growing organs. It has been believed that regulation at G2/M in the cell cycle is particularly important for plants that show endoreplication in their organ growth. In our genetic studies using Arabidopsis mutant with deregulated activity of mitotic regulator APC/C that acts as E3 ubiquitin ligase, we showed the possibility that a novel mechanism of cell cycle checkpoint may exist and may inhibit G2/M progression when nuclear mRNA metabolism is occasionally impaired. We also showed that MYB3R transcription factors, known as central regulators of G2/M-specific genes, play an important role in growth inhibition under salt stress, partially through its roles in gibberellin signal transduction where MYB3Rs physically interact with DELLA proteins and mediate the growth inhibition caused by the action of DELLA.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (37 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (9 results) Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Int'l Joint Research: 1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] University of London/Aberystsyth University(英国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of Tubingen/University of Hamburg(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Biological Research Centre(ハンガリー)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of California/Miami University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Polish Academy of Sciences(ポーランド)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] University of London/Aberystwyth University(英国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Tubingen(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Biological Research Centre(ハンガリー)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Univ. Natural Resources Life Sci(オーストリア)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTALIKE1 ligand-receptor signaling.2017

    • Author(s)
      Qi, X., Han, S.K., Dang, J.H., Garrick, J.M., Ito, M., Hofstetter, A.K., Torii, K.U.
    • Journal Title

      Elife

      Volume: 6 Pages: 24012-24012

    • DOI

      10.7554/elife.24102

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Haspin kinase has multiple functions in the plant cell division regulatory network.2016

    • Author(s)
      Kozgunova, E., Suzuki, T., Ito, M., Higashiyama, T., Kurihara, D.
    • Journal Title

      Plant Cell Physiol.

      Volume: 57 Issue: 4 Pages: 848-861

    • DOI

      10.1093/pcp/pcw030

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unique mechanisms of plant cell division regulated by multi-protein complexes2016

    • Author(s)
      伊藤正樹, 笹部美知子, 町田泰則
    • Journal Title

      Leading Author's

      Volume: 5 Pages: e005

    • DOI

      10.7875/leading.author.5.e005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MYB3Rs, plant homologs of Myb oncoproteins, control cell cycle-regulated transcription and form DREAM-like complexes.2015

    • Author(s)
      Kobayashi, K., Suzuki, T., Iwata, E., Magyar, Z., Bogre, L., Ito, M.
    • Journal Title

      Transcription

      Volume: 6 Issue: 5 Pages: 106-111

    • DOI

      10.1080/21541264.2015.1109746

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transcriptional repression by MYB3R proteins regulates plant organ growth.2015

    • Author(s)
      Kobayashi K, Suzuki T, Iwata E, Nakamichi N, Suzuki T, Chen P, Ohtani M, Ishida T, Hosoya H, Müller S, Leviczky T, Pettkó-Szandtner A, Darula Z, Iwamoto A, Nomoto M, Tada Y, Higashiyama T, Demura T, Doonan JH, Hauser MT, Sugimoto K, Umeda M, Magyar Z, Bögre L, Ito M
    • Journal Title

      EMBO Journal

      Volume: 34 Issue: 15 Pages: 1992-2007

    • DOI

      10.15252/embj.201490899

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reprogramming of plant cells induced by 6b oncoproteins from the plant pathogen Agrobacterium.2015

    • Author(s)
      Ito, M., Machida, Y.
    • Journal Title

      J. Plant Res.

      Volume: 未定 Issue: 3 Pages: 423-435

    • DOI

      10.1007/s10265-014-0694-3

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid Elimination of the Persistent Synergid through a Cell Fusion Mechanism.2015

    • Author(s)
      丸山大輔、Ronny Völz、竹内英憲、森稔幸、井川智子、栗原大輔、河島友和、植田美那子、伊藤正樹、梅田正明、西川周一、Rita Groß-Hardt、東山哲也
    • Journal Title

      Cell

      Volume: 未定 Issue: 4 Pages: 907-918

    • DOI

      10.1016/j.cell.2015.03.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic interaction between G2/M phase-specific transcription factor MYB3R4 and MAPKKK ANP3 for execution of cytokinesis in Arabidopsis thaliana.2015

    • Author(s)
      Saito, T., Fujikawa, H., Haga, N., Suzuki, T., Machida, Y., Ito, M.
    • Journal Title

      Plant Signal. Behav.

      Volume: 未定 Issue: 3 Pages: e990817-e990817

    • DOI

      10.4161/15592324.2014.990817

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Rapid elimination of the persistent synergid through a cell-fusion for polytubey block.2015

    • Author(s)
      Maruyama, D., Völz, R., Takeuchi, H., Mori, T., Igawa, T., Kurihara, D., Kawashima, T., Ueda, M., Ito, M., Umeda, M., Nishikawa, S., Groß-Hardt, R., Higashiyama, T.
    • Journal Title

      Cell

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The carboxyl-terminal tail of the stalk of Arabidopsis NACK1/HINKEL kinesin is required for its localization to the cell plate formation site2015

    • Author(s)
      Sasabe, M., Ishibashi, N., Haruta, T., Minami, A., Kurihara, D., Higashiyama, T., Nishihama, R., Ito, M., and Machida, Y.
    • Journal Title

      J. Plant Res.

      Volume: 128 Issue: 2 Pages: 327-336

    • DOI

      10.1007/s10265-014-0687-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 核内倍加を起こさないイネにおける細胞増殖制御の特性2017

    • Author(s)
      栂根美佳、坂本勇貴、長谷川淳子、松永幸大、伊藤正樹
    • Organizer
      第58会日本植物生理学会年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] RNA代謝異常と細胞周期抑制を結ぶ新奇チェックポイント機構の存在の可能性2017

    • Author(s)
      高瀬めぐみ、鈴木孝征、大谷美沙都、伊藤正樹
    • Organizer
      第58会日本植物生理学会年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2017-03-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Transcriptional repression by MYB3R proteins is required for spatial and temporal regulation of cell division.2016

    • Author(s)
      Kobayashi, K., Suzuki, T., Magyar, Z., Bogre, L., Ito, M
    • Organizer
      The 2016 Cold Spring Harbor Asia Conference “Latest advances in plant development & environmental response”
    • Place of Presentation
      Awaji
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] なぜイネは核内倍加を起こさないのか2016

    • Author(s)
      栂根美佳、長谷川淳子、松永幸大、伊藤正樹
    • Organizer
      日本植物学会第80会大会
    • Place of Presentation
      宜野湾
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] サイクリン依存性キナーゼ阻害因子SMRの発現制御に関わるGRASファミリー転写因子2016

    • Author(s)
      鈴木俊哉、伊藤正樹
    • Organizer
      日本植物学会第80会大会
    • Place of Presentation
      宜野湾
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] G2/M期制御に関わるMYB転写因子のジベレリンシグナル伝達系における役割2016

    • Author(s)
      奥村徹、伊藤正樹
    • Organizer
      日本植物学会第80会大会
    • Place of Presentation
      宜野湾
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 塩ストレス下での成長抑制に必須なシロイヌナスナMYB3R転写抑制因子2016

    • Author(s)
      奥村徹、鈴木孝征、東山哲也、伊藤正樹
    • Organizer
      第57回日本植物生理学会年会
    • Place of Presentation
      盛岡
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] シロイヌナズナを用いた後期促進複合体APC/Cの新奇標的因子の同定2016

    • Author(s)
      鈴木俊哉、桑田啓子、伊藤正樹
    • Organizer
      第57回日本植物生理学会年会
    • Place of Presentation
      盛岡
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多倍数体細胞を生じるイネ変異体の解析2015

    • Author(s)
      栂根美佳、栂根一夫、寺内良平、鈴木 孝征、東山哲也、長岐清孝、伊藤正樹
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 植物特異的なGRASファミリー転写因子による細胞分裂とDNA倍数性の制御2015

    • Author(s)
      鈴木俊哉、Christian Breuer、石田喬志、鈴木孝征、東山哲也、杉本慶子、伊藤正樹
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 葯壁タペート細胞で起こるDNA倍加のメカニズム2015

    • Author(s)
      鈴木俊哉、浜村有希、東山哲也、石黒澄衛、伊藤正樹
    • Organizer
      日本植物学会第79回大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] イネ体細胞のDNA倍数性に影響を与える遺伝子の解析2015

    • Author(s)
      栂根美佳、井上慎子、栂根一夫、寺内良平、永澤信洋、前川雅彦、伊藤正樹
    • Organizer
      第56回日本植物生理学会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] GRASファミリー転写因子によるシロイヌナズナの細胞分裂と核内倍加の制御2015

    • Author(s)
      鈴木俊哉,Christian Breuer,石田喬志,鈴木孝征,東山哲也,杉本慶子,伊藤正樹
    • Organizer
      第56回日本植物生理学会年会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] イネ体細胞のDNA倍数性に影響を与える遺伝子の解析2014

    • Author(s)
      栂根美佳、井上慎子、栂根一夫、寺内良平、永澤信洋、前川雅彦、伊藤正樹
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 植物特異的なGRASファミリー転写因子による細胞周期の制御2014

    • Author(s)
      鈴木俊哉,Christian Breuer,石田喬志,鈴木孝征,東山哲也,杉本慶子,伊藤正樹
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Remarks] 伊藤研究グループ

    • URL

      https://www.agr.nagoya-u.ac.jp/~bunka/ito_title%20page.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 伊藤研究グループ

    • URL

      https://www.agr.nagoya-u.ac.jp/̃bunka/ito_title%20page.html

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 植物のDNA倍加誘導法2016

    • Inventor(s)
      伊藤正樹、栂根美佳、梅田正明
    • Industrial Property Rights Holder
      伊藤正樹、栂根美佳、梅田正明
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-143238
    • Filing Date
      2016-07-21
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-16  

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