The origin and evolution of the antidiuretic hormone revealed by novel neurohypophysial hormone receptors

• Project/Area Number: 26291065
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Morphology/Structure
• Research Institution: The University of Tokyo
• Principal Investigator: HYODO SUSUMU 東京大学, 大気海洋研究所, 准教授 (40222244)
• Co-Investigator(Kenkyū-buntansha): 工樂 樹洋 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (40391940) ; 今野 紀文 富山大学, 大学院理工学研究部(理学), 講師 (50507051)
• Co-Investigator(Renkei-kenkyūsha): KAIYA HIROYUKI 国立循環器病研究センター, 生化学部, 研究室長 (40300975) ; KANDA SHINJI 東京大学理学系研究科, 准教授 (50634284)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000); Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 抗利尿ホルモン / バソトシン / 受容体 / 体液調節 / 産卵調節 / 分子進化 / ゲノム編集 / V2受容体 / ホメオスタシス / 輸卵管収縮 / 摂食 / 水電解質代謝 / 進化 / 腎機能 / 脊椎動物進化 / バソプレシン / 生殖 / 神経葉ホルモン

Outline of Final Research Achievements

Vasopressin/vasotocin is the well-known "antidiuretic hormone" in tetrapods. The aim of this study is to clarify function of vasotocin in aquatic fishes, and thus uncovering contribution of vasotocin to vertebrate evolution. To this end, we cloned neurohypophysial hormone receptors from elasmobranch catshark, lamprey and hagfish, and conducted functional characterization of cloned receptors. Our results revealed that V2aR, a receptor mediating the antidiuretic action in tetrapods, appeared firstly in ray-finned fish, but V2aR does not mediate the antidiuretic action in medaka. Meanwhile, the distribution of V1aR and V2bR indicates that vasotocin exerts stress response and oviposition via V1aR and V2bR, respectively. Vasotocin treatment of the posterior part of oviduct showed dose-dependent contraction. Based on the obtained results, we successfully proposed a comprehensive picture showing the molecular and functional evolution of neurohypophysial hormone system.

Research Products

• [Int'l Joint Research] ハワイ大学(米国)
• [Int'l Joint Research] ディーキン大学/タスマニア大学(オーストラリア)
• [Journal Article] Sulfate transporters involved in sulfate secretion in the kidney are localized in the renal proximal tubule II of the elephant fish (Callorhinchus milii) (2016)
  • Author(s): Hasegawa, K., Kato, A., Watanabe, T., Takagi, W., Romero, M., Bell, J.D., Toop, T., Donald, J.A. and Hyodo, S
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 311 Pages: 66-78
  • DOI: 10.1152/ajpregu.00477.2015
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Distribution and dynamics of branchial ionocytes in houndshark reared in full-strength and diluted seawater environments. (2016)
  • Author(s): Souichirou Takabe, Mayu Inokuchi, Yoko Yamaguchi and Susumu Hyodo
  • Journal Title: Comparative biochemistry and physiology Volume: 198 Pages: 22-32
  • DOI: 10.1016/j.cbpa.2016.03.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Atmospheric depression-mediated water temperature changes affect the vertical movement of chum salmon Oncorhynchus keta. (2016)
  • Author(s): Takashi Kitagawa, Susumu Hyodo, Katsufumi Sato
  • Journal Title: Marine Environmental Research Volume: 119 Pages: 72-78
  • DOI: 10.1016/j.marenvres.2016.05.016
  • Peer Reviewed / Open Access
• [Journal Article] On the vagal cardiac nerves, with special reference to the early evolution of the head-trunk interface (2016)
  • Author(s): Higashiyama, H., Hirasawa, T., Oisi, Y., Sugahara, F., Hyodo, S., Kanai, Y., and Kuratani, S.
  • Journal Title: Journal of morphology Volume: 277 Pages: 1146-1158
  • DOI: 10.1002/jmor.20563
  • Peer Reviewed
• [Journal Article] Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish (2016)
  • Author(s): Sakamoto, T., Yoshiki, M., Takahashi, H., Yoshida, M., Ogino, Y., Ikeuchi, T., Nakamachi, T., Konno, N., Matsuda, K. and Sakamoto, H.
  • Journal Title: Scientific Reports. Volume: - Pages: 37991-37991
  • DOI: 10.1038/srep37991
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain. (2016)
  • Author(s): Fumiaki Sugahara, Juan Pascual-Anaya, Yasuhiro Oisi, Shigehiro Kuraku, Shin-IchiAota, Noritaka Adachi, Wataru Takagi, Tamami Hirai, Noboru Sato, Yasunori Murakami, Shigeru Kuratani
  • Journal Title: Ｎａｔｕｒｅ Volume: 531 Pages: 97-100
  • DOI: 10.1038/nature16518
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Evolutionary diversification of retinoic acid receptor (RAR) ligand-binding pocket structure by molecular tinkering (2016)
  • Author(s): Gutierrez-Mazariegos, J., Nadendla, E.K., Studer, R.A., Alvarez, S., de Lera, A.R., Kuraku, S., Bourguet, W., Schubert, M. and Laudet, V
  • Journal Title: Royal Society Open Science Volume: 3 Pages: 150484-150484
  • DOI: 10.1098/rsos.150484
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A shift in anterior-posterior positional information underlies the fin-to limb evolution. (2016)
  • Author(s): Koh Onimaru, Shigehiro Kuraku, Wataru Takagi, Susumu Hyodo, James Sharpe and Mikiko Tanaka
  • Journal Title: eLife Volume: eLife 2015;4:e07048
  • DOI: 10.7554/elife.07048
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Morphological and molecular investigations of the holocephalan elephant fish nephron: the existence of a countercurrent-like configuration and two separate diluting segments in the distal tubule (2015)
  • Author(s): Kakumura, K., Takabe, S., Takagi, W., Hasegawa, K., Konno, N., Bell, J., Toop, T., Donald, J., Kaneko, T., and Hyodo, S.
  • Journal Title: Cell Tissue Res. Volume: 362 Pages: 677-688
  • DOI: 10.1007/s00441-015-2234-4
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neurophypophysial hormones regulate amphibious behavior in the mudskipper goby. (2015)
  • Author(s): Sakamoto et al.
  • Journal Title: PLoS One Volume: 10 Pages: 1-16
  • DOI: 10.1371/journal.pone.0134605
  • Peer Reviewed / Open Access
• [Journal Article] Discovery of conventional prolactin from the holocephalan elephant fish, Callorhinchus milii. (2015)
  • Author(s): Yamaguchi, Y., Takagi, W., Kuraku, S., Moriyama, S., Bell, J.D., Seale, A.P., Lerner, D.T., Grau, E.G. and Hyodo, S.
  • Journal Title: General and Comparative Endocrinology Volume: 224 Pages: 216-227
  • DOI: 10.1016/j.ygcen.2015.08.020
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Urotensin II upregulates migration and cytokine gene expression in leukocytes of the African clawed frog, Xenopus laevis (2015)
  • Author(s): Tomiyama, S., Nakamachi, T., Uchiyama, M., Matsuda, K., and Konno, N.
  • Journal Title: General and Comparative Endocrinology Volume: in press Pages: 54-63
  • DOI: 10.1016/j.ygcen.2015.04.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cloning and expression of the epithelial sodium channel and its role in osmoregulation of aquatic and estivating African lungfish Protopterus annectens. (2015)
  • Author(s): Minoru Uchiyama, Norifumi Konno, Sachika Shibuya and Satoshi Nogami
  • Journal Title: Comparative Biochemistry and Physiology Volume: 183 Pages: 1-8
  • DOI: 10.1016/j.cbpa.2014.12.028
  • Peer Reviewed
• [Journal Article] Evolution of retinoic acid receptors in chordates: insights from three lamprey species, Lampetra fluviatilis, Petromyzon marinus, and Lethenteron japonicum. (2015)
  • Author(s): Campo-Paysaa, F., Jandzik, D., Takio-Ogawa, Y., Cattell, M. V, Neef, H. C., Langeland, J. A., Kuratani, S., Medeiros, D. M., Mazan, S., Kuraku, S., Laudet, V., and Schubert, M.
  • Journal Title: EvoDevo Volume: 6 Pages: 18-18
  • DOI: 10.1186/s13227-015-0016-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optimization and cost-saving in tagmentation-based mate-pair library preparation and sequencing. (2015)
  • Author(s): Tatsumi, K., Nishimura, O., Itomi, K., Tanegashima, C. and Kuraku, S.
  • Journal Title: Biotechniques Volume: 58 Pages: 253-257
  • DOI: 10.2144/000114288
  • Peer Reviewed
• [Journal Article] Reevaluating Emx gene phylogeny: homopolymeric amino acid tracts as a potential factor obscuring orthology signals in cyclostome genes. (2015)
  • Author(s): Noro, M., Sugahara, F. and Kuraku, S.
  • Journal Title: BMC evolutionary biology Volume: 15 Pages: 78-78
  • DOI: 10.1186/s12862-015-0351-z
  • Peer Reviewed / Open Access
• [Journal Article] Optimizing and benchmarking de novo transcriptome sequencing: from library preparation to assembly evaluation. (2015)
  • Author(s): Hara, Y., Tatsumi, K., Yoshida, M., Kajikawa, E., Kiyonari, H. and Kuraku S.
  • Journal Title: BMC Genomics Volume: 16 Pages: 977-977
  • DOI: 10.1186/s12864-015-2007-1
  • Peer Reviewed / Open Access
• [Journal Article] Urea-based osmoregulation in the developing embryo of oviparous cartilaginous fish (Callorhinchus milii): contribution of the extraembryonic yolk sac during the early developmental period. (2014)
  • Author(s): Takagi, l., Kajimura, M., Tanaka, H., Hasegawa, K., Bell, J. D., Toop, T., Donald, J. A. and Hyoda., S.
  • Journal Title: Journal of Experimental Biology Volume: 217 Pages: 1353-1362
  • DOI: 10.1242/jeb.094649
  • Peer Reviewed
• [Journal Article] Morphological and functional characteristics of the kidney of cartilaginous fishes: with special reference to urea reabsorption. (2014)
  • Author(s): Hyodo, S., Kakumura, K., Takagi, W., Hasegawa, K. and Yamaguchi, Y.
  • Journal Title: American Journal of Physiology Regulatory and Integrative Comparative Physiology Volume: 307
  • DOI: 10.1152/ajpregu.00033.2014
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene. (2014)
  • Author(s): Feiner, N., Meyer, A. and Kuraku, S.
  • Journal Title: Genome Biology and Evolution Volume: 6 Pages: 1635-1651
  • DOI: 10.1093/gbe/evu135
  • Peer Reviewed
• [Journal Article] Mechanisms of endoderm formation in a cartilaginous fish reveal ancestral and homoplastic traits in jawed vertebrates. (2014)
  • Author(s): Godard, B.G., Coolen, M., Le Panse, S., Gombault, A., Ferreiro-Galve, S., Laguerre, L., Lagadec, R., Wincker, P., Poulain, J., Da Silva, C., Kuraku, S., Carre, W., Boutet, A. and Mazan, S.
  • Journal Title: Biology Open Volume: 3 Pages: 1098-1107
  • DOI: 10.1242/bio.20148037
  • Peer Reviewed / Open Access
• [Journal Article] Identification, tissue distribution and functional characterization of the ghrelin receptor in West African lungfish, Protopterus annectens. (2014)
  • Author(s): Kaiya H, Konno N, Kangawa K, Uchiyama M, Miyazato M
  • Journal Title: Gen. Comp. Endocrinol. Volume: 209 Pages: 106-117
  • DOI: 10.1016/j.ygcen.2014.07.021
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] バソプレシン/バソトシンの浸透圧調節作用からみた脊椎動物の環境適応と進化 (2014)
  • Author(s): 今野紀文
  • Journal Title: 比較生理生化学 Volume: 31 Pages: 68-74
• [Presentation] ストレス刺激がサメの摂食に与える影響 (2016)
  • Author(s): 位寄あゆこ、Anderson WG.、兵藤晋
  • Organizer: 第41回日本比較内分泌学会
  • Place of Presentation: 北里大学相模原キャンパス，神奈川県相模原市
  • Year and Date: 2016-12-09
• [Presentation] トラザメの脳下垂体ならびに生殖器官における神経葉ホルモンの機能 (2016)
  • Author(s): 井上夏紀、山口陽子、兵藤晋
  • Organizer: 第41回日本比較内分泌学会
  • Place of Presentation: 北里大学相模原キャンパス，神奈川県相模原市
  • Year and Date: 2016-12-09
• [Presentation] バソトシンノックアウトメダカの自発遊泳行動の解析 (2016)
  • Author(s): 井口わかな、神田真司、中町智哉、松田恒平、今野紀文
  • Organizer: 第41回日本比較内分泌学会大会
  • Place of Presentation: 北里大学相模原キャンパス，神奈川県相模原市
  • Year and Date: 2016-12-09
• [Presentation] オオメジロザメはなぜ川に上がるのか-西表島浦内川における遡上と生態 (2016)
  • Author(s): 櫻井もも子、今関到、兵藤晋、立原一憲
  • Organizer: 板鰓類シンポジウム
  • Place of Presentation: 葛西臨海水族園、東京都江戸川区
  • Year and Date: 2016-12-03
• [Presentation] オオメジロザメはなぜ川を上がることができるのか-飼育実験とトランスクリプトーム解析による広塩性メカニズムの研究 (2016)
  • Author(s): 今関到、若林翠、工樂樹洋、原雄一郎、櫻井もも子、立原一憲、兵藤晋
  • Organizer: 板鰓類シンポジウム
  • Place of Presentation: 葛西臨海水族園，東京都江戸川区
  • Year and Date: 2016-12-03
• [Presentation] 板鰓類ゲノム研究の動向: 遺伝子でみるサメらしさとは？ (2016)
  • Author(s): 工樂樹洋
  • Organizer: 板鰓類シンポジウム
  • Place of Presentation: 葛西臨海水族園、東京都江戸川区
  • Year and Date: 2016-12-03
• [Presentation] Environmental adaptation of marine organisms (2016)
  • Author(s): Susumu Hyodo
  • Organizer: NTU-UTOKYO Joint Conference
  • Place of Presentation: 国立台湾大学、台北、台湾
  • Year and Date: 2016-11-30
  • Int'l Joint Research / Invited
• [Presentation] A new perspective for the origin of appendicular muscles (2016)
  • Author(s): Okamoto E., Kusakabe R., Kuraku S., Hyodo S., Onimaru K., Kuratani S., Tanaka M.
  • Organizer: The 22nd International Congress of Zoology
  • Place of Presentation: Okinawa Institute for Science and Technology、沖縄県国頭郡恩納村
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] Molecular evolution of prolactin: new insights from a recent study in cartilaginous fish (2016)
  • Author(s): Yamaguchi Y., Takage W., Kuraku S., Moriyama S., Bell JD., Seale AP., Lerner DT., Grau EG., Hyodo S.
  • Organizer: The 22nd International Congress of Zoology
  • Place of Presentation: 沖縄コンベンションセンター、沖縄県宜野湾市
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] The role of vasotocin V2a-type receptor in teleost: insights from studies using V2aR-knockout Medaka (2016)
  • Author(s): Konno N., Kanda S., Hyodo S., Matsuda K.
  • Organizer: The 22nd International Congress of Zoology
  • Place of Presentation: 沖縄コンベンションセンター、沖縄県宜野湾市
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] The origin of appendicular muscles: perspectives from the catshark (2016)
  • Author(s): Okamoto E., Kusakabe R., Kuraku S., Hyodo S., Onimaru K., Kuratani S., Tanaka M.
  • Organizer: The 22nd International Congress of Zoology
  • Place of Presentation: 沖縄コンベンションセンター、沖縄県宜野湾市
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Electrophysiological and genetic demonstration that VT neuron is critical for water excretion in hypoosmotic conditions in medaka (2016)
  • Author(s): Shinya M., Kanda S., Takahashi A., Konno N., Hyodo S., Kagawa N., Oka Y.
  • Organizer: The 22nd International Congress of Zoology
  • Place of Presentation: 沖縄コンベンションセンター、沖縄県宜野湾市
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Identification of a novel epithelial factor enhancing salinity tolerance in Japanese medaka (2016)
  • Author(s): Miyanishi H., Watanabe T., Hyodo S., Kaneko T.
  • Organizer: The 22nd International Congress of Zoology
  • Place of Presentation: 沖縄コンベンションセンター、沖縄県宜野湾市
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] What did we learn from the genomes of two lamprey species, Petromyzon marinus and Lethenteron camtschaticum? (2016)
  • Author(s): Shigehiro Kuraku
  • Organizer: The 22nd International Congress of Zoology
  • Place of Presentation: Okinawa Institute of Science and Technology、沖縄県国頭郡恩納村
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] 円口類と軟骨魚類におけるマルチオミクス解析のためのリソース整備 (2016)
  • Author(s): 工樂樹洋
  • Organizer: 海洋生物の適応戦略：新規技術・現象からの新展開
  • Place of Presentation: 東京大学大気海洋研究所，千葉県柏市
  • Year and Date: 2016-09-15
  • Invited
• [Presentation] Functional characterization of Vasotocin V2a-type receptor knockout Medaka generated by transcription activator-like effector nucleases (TALENs) technology. (2016)
  • Author(s): Inagaki, Y., Kato, H., Kanda, S., Hyodo, S., Matsuda, K. and Konno, N.
  • Organizer: International Symposium on Pituitary Gland and Related Systems
  • Place of Presentation: ハワイ大学マノア校 East-West Center、ホノルル、米国
  • Year and Date: 2016-09-01
  • Int'l Joint Research
• [Presentation] New insights into the molecular evolution of classical hormones: lessons from cartilaginous fish (2016)
  • Author(s): Susumu Hyodo
  • Organizer: The 8th Congress of Asia and Oceania Society for Comparative Endocrinology
  • Place of Presentation: Korea University College of Medicine、ソウル、韓国
  • Year and Date: 2016-06-20
  • Int'l Joint Research / Invited
• [Presentation] Dynamics of plasma corticosteroid in cannulated houndsharks under various stress condition. (2015)
  • Author(s): Ayuko Iki and Susumu Hyodo
  • Organizer: 日本比較内分泌学会第40回大会（CompBiol 2015）
  • Place of Presentation: JMSアステールプラザ、広島
  • Year and Date: 2015-12-11
• [Presentation] Distribution and function of neurohypophysial hormone receptors in catshark. (2015)
  • Author(s): Natsuki Inoue, Yoko Yamaguchi, Hiroyuki Kaiya, Shigehiro Kuraku and Susumu Hyodo
  • Organizer: 日本比較内分泌学会第40回大会（CompBiol 2015）
  • Place of Presentation: JMSアステールプラザ、広島
  • Year and Date: 2015-12-11
• [Presentation] ベタの攻撃行動と繁殖行動は脳内性ホルモンレベルにより制御される (2015)
  • Author(s): 今野紀文、島崎祐希、中町智哉、松田恒平
  • Organizer: 平成27年度日本動物学会中部支部大会
  • Place of Presentation: 三重大学総合研究棟Ⅱ、三重
  • Year and Date: 2015-11-28
• [Presentation] 非哺乳類を用いた比較研究からウロテンシンⅡの新機能を探る (2015)
  • Author(s): 今野紀文、海谷啓之
  • Organizer: 第6回ペプチド・ホルモン研究会
  • Place of Presentation: 金沢大学臨海実験施設、石川
  • Year and Date: 2015-10-16
• [Presentation] アクアポリンの局在から明らかとなった軟骨魚類腎臓における尿素再吸収機構 (2015)
  • Author(s): 長谷川久美、角村佳吾、兵藤晋
  • Organizer: 日本動物学会第86回大会
  • Place of Presentation: 新潟コンベンションセンター 朱鷺メッセ、新潟
  • Year and Date: 2015-09-17
• [Presentation] トラザメの下垂体における糖タンパク質ホルモンcDNAのクローニングと発現部位の同定 (2015)
  • Author(s): 内田勝久、井上夏紀、兵藤晋、香川浩彦
  • Organizer: 日本動物学会第86回大会
  • Place of Presentation: 新潟コンベンションセンター 朱鷺メッセ、新潟
  • Year and Date: 2015-09-17
• [Presentation] 両生類における新規AQPの同定及びAQPの分子進化 (2015)
  • Author(s): 石井凌、柴田侑毅、垣内裕貴、嘉手苅将、常磐俊大、兵藤晋、内山実、宇根有美、スタンリー ヒルヤード、長井孝紀、鈴木雅一
  • Organizer: 日本動物学会第86回大会
  • Place of Presentation: 新潟コンベンションセンター 朱鷺メッセ、新潟
  • Year and Date: 2015-09-17
• [Presentation] Assessing vertebrate homolog space (2015)
  • Author(s): Kuraku, S.
  • Organizer: 4th Quest for Orthologs Meeting
  • Place of Presentation: Barcelona Biomedical Research Park, Barcelona, Spain
  • Year and Date: 2015-05-25
  • Int'l Joint Research / Invited
• [Presentation] Vanishing phylogenetic signals? revisiting molecular phylogenies of cyclostome genes. (2015)
  • Author(s): Kuraku, S.
  • Organizer: Symposium on Palaeontological and molecular approaches to early vertebrate evolution
  • Place of Presentation: Uppsala University, Uppsala, Sweden
  • Year and Date: 2015-05-12
  • Int'l Joint Research / Invited
• [Presentation] 脊椎動物ファイローム～分子生物学の基本ツールとしての分子系統学へ～ (2014)
  • Author(s): 工樂樹洋
  • Organizer: 新学術領域「複合適応形質進化の遺伝子基盤解明」第7回オープンセミナー
  • Place of Presentation: 東京大学柏キャンパス、千葉
  • Year and Date: 2014-12-11 – 2014-12-12
  • Invited
• [Presentation] ウロテンシンⅡによる軟骨基質形成の可能性 (2014)
  • Author(s): 今野紀文、今江春香、内山 実、中町智哉、松田恒平
  • Organizer: 平成26年度日本動物学会中部支部大会
  • Place of Presentation: 能登勤労者プラザ、金沢
  • Year and Date: 2014-11-23
• [Presentation] 軟骨魚類ゾウギンザメの脳下垂体からのプロラクチンの発見 (2014)
  • Author(s): 山口陽子、高木亙、工樂樹洋、森山俊介、兵藤晋
  • Organizer: 第85回日本動物学会大会
  • Place of Presentation: 東北大学、仙台、宮城
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] トラザメの性分化 (2014)
  • Author(s): 中村將、野津了、高岡博子、村雲清美、兵藤晋、佐藤圭一
  • Organizer: 第85回日本動物学会大会
  • Place of Presentation: 東北大学、仙台、宮城
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] ウロテンシンⅡはアフリカツメガエルにおいて白血球遊走とサイトカイン合成に関与する (2014)
  • Author(s): 富山詩織、内山 実、中町智哉、松田恒平、今野紀文
  • Organizer: 第85回日本動物学会大会
  • Place of Presentation: 東北大学、仙台、宮城
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 闘魚ベタの攻撃行動と脳内バソトシン発現との関連 (2014)
  • Author(s): 今野紀文、小池俊貴、岩田恵理、内山 実、松田恒平
  • Organizer: 第85回日本動物学会大会
  • Place of Presentation: 東北大学、仙台、宮城
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] ２Ｒ全ゲノム重複説のその後：いま何が問題でなぜ難しいのか (2014)
  • Author(s): 工樂樹洋
  • Organizer: 第16回日本進化学会年会
  • Place of Presentation: 高槻現代劇場、高槻、大阪
  • Year and Date: 2014-08-21 – 2014-08-24
• [Presentation] Molecular-histochemical investigation of cartilaginous fish kidney (2014)
  • Author(s): Hyodo, S., Hasegawa, K., Takagi, W. and Kakumura, K.
  • Organizer: 11th International Congress on the Biology of Fish
  • Place of Presentation: Heriot-Watt University, Edinburgh, Scotland
  • Year and Date: 2014-08-03 – 2014-08-07
  • Invited
• [Presentation] A functional shift of urea-producing site from extraembryonic yolk sac to liver in the developing embryos of two oviparous cartilaginous fishes (2014)
  • Author(s): Takagi, W., Kajimura, M., Tanaka, H., Bell, J.D. and Hyodo, S.
  • Organizer: 11th International Congress on the Biology of Fish
  • Place of Presentation: Heriot-Watt University, Edinburgh, Scotland
  • Year and Date: 2014-08-03 – 2014-08-07
  • Invited
• [Presentation] Revealing cryptic pan-vertebrate gene repertoire in developmental phylome (2014)
  • Author(s): Kuraku, S.
  • Organizer: The 5th meeting of the European Society for Evolutionary Developmental Biology
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-07-22 – 2014-07-25
  • Invited
• [Book] Academic Press (2016)
  • Author(s): Susumu Hyodo
  • Publisher: Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research
• [Book] Molecular evolution in the lamprey genomes and its relevance to the timing of whole genome duplications. (2016)
  • Author(s): Manousaki, T., Qiu, H., Noro, M., Hildebrand, F., Meyer, A. and Kuraku, S.
  • Publisher: Cambridge Scholars Publishing
• [Book] ホメオスタシスと適応（ホルモンから見た生命現象と進化シリーズ5）：体液調節機構の進化：魚類 (2016)
  • Author(s): 兵藤晋
  • Publisher: 裳華房
• [Book] ホメオスタシスと適応（ホルモンから見た生命現象と進化シリーズ5）：体液調節機構の進化：陸上生物 (2016)
  • Author(s): 今野紀文
  • Publisher: 裳華房
• [Book] Handbook of Hormones, Comparative Endocrinology for Basic and Clinical Research (2015)
  • Author(s): Hyodo, S.
  • Publisher: Academic Press
• [Book] Handbook of Hormones, Comparative Endocrinology for Basic and Clinical Research (2015)
  • Author(s): Konno, N.
  • Publisher: Academic Press
• [Remarks] 東京大学大気海洋研究所・生理学分野・兵藤晋
  • URL: http://seiri-aori.org/index.php?id=12
• [Remarks] 理化学研究所・ライフサイエンス技術基盤研究センター・分子配列比較解析ユニット・工樂樹洋
  • URL: http://www2.clst.riken.jp/phylo/
• [Remarks] 理化学研究所・ライフサイエンス技術基盤研究センター・分子配列比較解析ユニット・工樂樹洋
  • URL: http://www2.clst.riken.jp/phylo/index.html
• [Remarks] 理化学研究所・ライフサイエンス技術基盤研究センター ・分子配列比較解析ユニット・工樂樹洋
  • URL: http://www.clst.riken.jp/phylo/