The origin and evolution of the antidiuretic hormone revealed by novel neurohypophysial hormone receptors
Project/Area Number |
26291065
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
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Research Institution | The University of Tokyo |
Principal Investigator |
HYODO SUSUMU 東京大学, 大気海洋研究所, 准教授 (40222244)
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Co-Investigator(Kenkyū-buntansha) |
工樂 樹洋 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (40391940)
今野 紀文 富山大学, 大学院理工学研究部(理学), 講師 (50507051)
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Co-Investigator(Renkei-kenkyūsha) |
KAIYA HIROYUKI 国立循環器病研究センター, 生化学部, 研究室長 (40300975)
KANDA SHINJI 東京大学理学系研究科, 准教授 (50634284)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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Keywords | 抗利尿ホルモン / バソトシン / 受容体 / 体液調節 / 産卵調節 / 分子進化 / ゲノム編集 / V2受容体 / ホメオスタシス / 輸卵管収縮 / 摂食 / 水電解質代謝 / 進化 / 腎機能 / 脊椎動物進化 / バソプレシン / 生殖 / 神経葉ホルモン |
Outline of Final Research Achievements |
Vasopressin/vasotocin is the well-known "antidiuretic hormone" in tetrapods. The aim of this study is to clarify function of vasotocin in aquatic fishes, and thus uncovering contribution of vasotocin to vertebrate evolution. To this end, we cloned neurohypophysial hormone receptors from elasmobranch catshark, lamprey and hagfish, and conducted functional characterization of cloned receptors. Our results revealed that V2aR, a receptor mediating the antidiuretic action in tetrapods, appeared firstly in ray-finned fish, but V2aR does not mediate the antidiuretic action in medaka. Meanwhile, the distribution of V1aR and V2bR indicates that vasotocin exerts stress response and oviposition via V1aR and V2bR, respectively. Vasotocin treatment of the posterior part of oviduct showed dose-dependent contraction. Based on the obtained results, we successfully proposed a comprehensive picture showing the molecular and functional evolution of neurohypophysial hormone system.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Sulfate transporters involved in sulfate secretion in the kidney are localized in the renal proximal tubule II of the elephant fish (Callorhinchus milii).2016
Author(s)
Hasegawa, K., Kato, A., Watanabe, T., Takagi, W., Romero, M., Bell, J.D., Toop, T., Donald, J.A. and Hyodo, S.
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Journal Title
American Journal of Physiology Regulatory and Integrative Comparative Physiology
Volume: 311
Pages: R66-R78
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish.2016
Author(s)
Sakamoto, T., Yoshiki, M., Takahashi, H., Yoshida, M., Ogino, Y., Ikeuchi, T., Nakamachi, T., Konno, N., Matsuda, K. and Sakamoto, H
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Journal Title
Scientific reports
Volume: 6
Pages: 37991
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain2016
Author(s)
Sugahara, F., Pascual-Anaya, J., Oisi, Y., Kuraku, S., Aota, S., Adachi, N., Takagi, W., Hirai, T., Sato, N., Murakami, Y. and Kuratani, S.
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Journal Title
Nature
Volume: 531
Pages: 97-100
DOI
Related Report
Peer Reviewed
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[Journal Article] Evolutionary diversification of retinoic acid receptor (RAR) ligand-binding pocket structure by molecular tinkering2016
Author(s)
Gutierrez-Mazariegos, J., Nadendla, E.K., Studer, R.A., Alvarez, S., de Lera, A.R., Kuraku, S., Bourguet, W., Schubert, M. and Laudet, V
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Journal Title
Royal Society Open Science
Volume: 3
Pages: 150484
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A shift in anterior-posterior positional information underlies the fin-to limb evolution.2015
Author(s)
Onimaru, K., Kuraku, S., Takagi, W., Hyodo, S., Sharpe, J. and Tanaka, M.
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Journal Title
eLife
Volume: 4
Pages: e07048
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Neurophypophysial hormones regulate amphibious behavior in the mudskipper goby.2015
Author(s)
Sakamoto, T., Nishiyama, Y., Ikeda, A., Takahashi, H., Hyodo, S., Kagawa, N. and Sakamoto, H.
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Journal Title
PLoS One
Volume: 10
Pages: e0134605
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Discovery of conventional prolactin from the holocephalan elephant fish, Callorhinchus milii.2015
Author(s)
Yamaguchi, Y., Takagi, W., Kuraku, S., Moriyama, S., Bell, J.D., Seale, A.P., Lerner, D.T., Grau, E.G. and Hyodo, S.
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Journal Title
General and Comparative Endocrinology
Volume: 224
Pages: 216-227
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Evolution of retinoic acid receptors in chordates: insights from three lamprey species, Lampetra fluviatilis, Petromyzon marinus, and Lethenteron japonicum.2015
Author(s)
Campo-Paysaa, F., Jandzik, D., Takio-Ogawa, Y., Cattell, M.V., Neef, H.C., Langeland, J.A., Kuratani, S., Medeiros, D.M., Mazan, S., Kuraku, S., Laudet, V. and Schubert, M.
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Journal Title
EvoDevo
Volume: 6
Pages: 18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Urea-based osmoregulation in the developing embryo of oviparous cartilaginous fish (Callorhinchus milii): contribution of the extraembryonic yolk sac during the early developmental period.2014
Author(s)
Takagi, W., Kajimura, M., Tanaka, H., Hasegawa, K., Bell, J.D., Toop, T., Donald, J.A., and Hyodo, S.
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Journal Title
Journal of Experimental Biology
Volume: 217
Pages: 1353-1362
DOI
Related Report
Peer Reviewed
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[Journal Article] Mechanisms of endoderm formation in a cartilaginous fish reveal ancestral and homoplastic traits in jawed vertebrates.2014
Author(s)
Godard, B.G., Coolen, M., Le Panse, S., Gombault, A., Ferreiro-Galve, S., Laguerre, L., Lagadec, R., Wincker, P., Poulain, J., Da Silva, C., Kuraku, S., Carre, W., Boutet, A. and Mazan, S.
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Journal Title
Biology Open
Volume: 3
Pages: 1098-1107
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification, tissue distribution and functional characterization of the ghrelin receptor in West African lungfish, Protopterus annectens.2014
Author(s)
Kaiya, H., Konno, N., Kangawa, K., Uchyama, M. and Miyazato, M.
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Journal Title
General and Comparative Endocrinology
Volume: 209
Pages: 106-117
DOI
Related Report
Peer Reviewed
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[Presentation] ストレス刺激がサメの摂食に与える影響2016
Author(s)
位寄あゆこ、Anderson WG.、兵藤晋
Organizer
第41回日本比較内分泌学会
Place of Presentation
北里大学相模原キャンパス,神奈川県相模原市
Year and Date
2016-12-09 – 2016-12-11
Related Report
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[Presentation] A new perspective for the origin of appendicular muscles2016
Author(s)
Okamoto E., Kusakabe R., Kuraku S., Hyodo S., Onimaru K., Kuratani S., Tanaka M.
Organizer
The 22nd International Congress of Zoology
Place of Presentation
Okinawa Institute for Science and Technology、沖縄県国頭郡恩納村
Year and Date
2016-11-14 – 2016-11-19
Related Report
Int'l Joint Research / Invited
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[Presentation] Functional characterization of Vasotocin V2a-type receptor knockout Medaka generated by transcription activator-like effector nucleases (TALENs) technology.2016
Author(s)
Inagaki, Y., Kato, H., Kanda, S., Hyodo, S., Matsuda, K. and Konno, N.
Organizer
International Symposium on Pituitary Gland and Related Systems
Place of Presentation
ハワイ大学マノア校 East-West Center、ホノルル、米国
Year and Date
2016-09-01 – 2016-09-05
Related Report
Int'l Joint Research
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[Presentation] Assessing vertebrate homolog space2015
Author(s)
Kuraku, S.
Organizer
4th Quest for Orthologs Meeting
Place of Presentation
Barcelona Biomedical Research Park, Barcelona, Spain
Year and Date
2015-05-25 – 2015-05-27
Related Report
Int'l Joint Research / Invited
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[Presentation] A functional shift of urea-producing site from extraembryonic yolk sac to liver in the developing embryos of two oviparous cartilaginous fishes2014
Author(s)
Takagi, W., Kajimura, M., Tanaka, H., Bell, J.D. and Hyodo, S.
Organizer
11th International Congress on the Biology of Fish
Place of Presentation
Heriot-Watt University, Edinburgh, Scotland
Year and Date
2014-08-03 – 2014-08-07
Related Report
Invited
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[Book] Molecular evolution in the lamprey genomes and its relevance to the timing of whole genome duplications.2016
Author(s)
Manousaki, T., Qiu, H., Noro, M., Hildebrand, F., Meyer, A. and Kuraku, S.
Total Pages
pp. 2-16
Publisher
Cambridge Scholars Publishing
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