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Molecular neural mechanisms for behavioral modulation by inter-individual communication

Research Project

Project/Area Number 26291069
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Animal physiology/Animal behavior
Research InstitutionThe University of Tokyo

Principal Investigator

IINO YUICHI  東京大学, 大学院理学系研究科(理学部), 教授 (40192471)

Co-Investigator(Renkei-kenkyūsha) KUNITOMO Hirofumi  東京大学, 大学院理学系研究科, 准教授 (20302812)
TOMIOKA Masahiro  東京大学, 大学院理学系研究科, 助教 (40466800)
TOYOSHIMA Yu  東京大学, 大学院理学系研究科, 助教 (10632341)
Research Collaborator TSUCHIYA Jun-ichi  東京大学, 大学院理学系研究科, 大学院生
TORIYABE Hiroshi  東京大学, 大学院理学系研究科, 大学院生
YANAGI Shuichi  東京大学, 大学院理学系研究科, 大学院生
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords異性間相互作用 / 個体群密度 / 嗅覚可塑性 / 線虫C. elegans / フェロモン / インスリンシグナル伝達経路 / 塩走性学習 / 線虫C.elegans
Outline of Final Research Achievements

To identify molecular mechanisms for inter-individual communication, we looked at the role of insulin pathway in the sexual learning. Also, we identified the role of TGF beta pathway in pheromone-dependent gene expression.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (31 results)

All 2017 2016 2015 2014

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 4 results) Presentation (18 results) (of which Int'l Joint Research: 10 results,  Invited: 5 results) Book (1 results)

  • [Journal Article] The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans2017

    • Author(s)
      Sakai Naoko、Ohno Hayao、Tomioka Masahiro、Iino Yuichi
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 5 Pages: e0177900-e0177900

    • DOI

      10.1371/journal.pone.0177900

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Luqin-like RYamide peptides regulate food-evoked responses in C. elegans2017

    • Author(s)
      Ohno H, Yoshida M, Sato T, Kato J, Miyazato M, Kojima M, Ida T, Iino Y
    • Journal Title

      Elife

      Volume: 6. pii Pages: 1-23

    • DOI

      10.7554/elife.28877

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Gustatory Neural Circuit of Caenorhabditis elegans Generates Memory-Dependent Behaviors in Na(+) Chemotaxis.2017

    • Author(s)
      Lifang Wang, Hirofumi Sato, Yohsuke Satoh, Masahiro Tomioka, Hirofumi Kunitomo and Yuichi Iino
    • Journal Title

      J Neurosci

      Volume: 37 Issue: 8 Pages: 2097-2111

    • DOI

      10.1523/jneurosci.1774-16.2017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Accurate Automatic Detection of Densely Distributed Cell Nuclei in 3D Space.2016

    • Author(s)
      Toyoshima Y, Tokunaga T, Hirose O, Kanamori M, Teramoto T, Jang MS, Kuge S, Ishihara T, Yoshida R, Iino Y.
    • Journal Title

      PLoS Comput Biol.

      Volume: 12 Issue: 6 Pages: 1-20

    • DOI

      10.1371/journal.pcbi.1004970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor.2016

    • Author(s)
      Masahiro Tomioka, Yasuki Naito, Hidehito KUROYANAGI, and Yuichi Iino.
    • Journal Title

      Nature Communications

      Volume: - Issue: 1 Pages: 11645-11645

    • DOI

      10.1038/ncomms11645

    • NAID

      120006348540

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth2016

    • Author(s)
      Endo, M., Hattori,M., Toriyabe, H., Ohno, H., Kamiguchi, H., Iino, Y. and Ozawa, T.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 23976-23976

    • DOI

      10.1038/srep23976

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modulation of different behavioral components by neuropeptide and dopamine signalings in non-associative odor learning of Caenorhabditis elegans.2015

    • Author(s)
      Yamazoe-Umemoto, A.;Fujita, K.;Iino, Y.;Iwasaki, Y.;Kimura, K. D.
    • Journal Title

      Neurosci Res

      Volume: 99 Pages: 22-33

    • DOI

      10.1016/j.neures.2015.05.009

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis for Na+ transport mechanism by a light-driven Na+ pump2015

    • Author(s)
      H. E. Kato, K. Inoue, R. Abe-Yoshizumi, Y. Kato, H. Ono, M. Konno, S. Hososhima, T. Ishizuka, M. R. Hoque, H. Kunitomo, J. Ito, S. Yoshizawa, K. Yamashita, M. Takemoto, T. Nishizawa, R. Taniguchi, K. Kogure, A. D. Maturana, Y. Iino, H. Yawo, R. Ishitani, H. Kandori*, O. Nureki*
    • Journal Title

      Nature

      Volume: 未定 Issue: 7550 Pages: 48-53

    • DOI

      10.1038/nature14322

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi2015

    • Author(s)
      Hamakawa M, Uozumi T, Ueda N, Iino Y & Hirotsu T
    • Journal Title

      BMC Biology

      Volume: 13 Issue: 1 Pages: 6-6

    • DOI

      10.1186/s12915-015-0114-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 個体間相互作用による線虫の匂いや味の嗜好性の変化2015

    • Author(s)
      飯野雄一
    • Journal Title

      エコロジカルボラタイルズ 生態系を紡ぐアロマ

      Volume: xx

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans2014

    • Author(s)
      Ohno H, Kato S, Naito Y, Kunitomo H, Tomioka M, Iino Y.
    • Journal Title

      Science

      Volume: 345 Issue: 6194 Pages: 313-7

    • DOI

      10.1126/science.1250709

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 異性のいる環境が忘れられない?-線虫の異性学習-2014

    • Author(s)
      酒井奈緒子・飯野雄一
    • Journal Title

      Aroma Research

      Volume: 15 Pages: 142-143

    • Related Report
      2014 Annual Research Report
  • [Presentation] CeRYamides, members of the conserved RYamide peptide family, mediate food responses after fasting in C. elegans2017

    • Author(s)
      Hayao Ohno, Morikatsu Yoshida, Takahiro Sato, Johji Kato, Mikiya Miyazato, Masayasu Kojima, Takanori Ida & Yuichi Iino
    • Organizer
      16th TMIMS International Symposium
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Neural mechanisms for sugar chemotaxis learning in Caenorhabditis elegans.2017

    • Author(s)
      Risshun Chin, Yutaro Ueoka, Chihiro Uchiyama, Keita Katae, Masahiro Tomioka, Yuichi Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Analysis of function of TORC2 Signaling Pathway in Associative Learning in Caenorhabditis elegans2017

    • Author(s)
      N. Sakai, H. Ohno, M. Tomioka, Y. Iino
    • Organizer
      21st International C. elegans Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] How taste preference is modulated in the nematode2017

    • Author(s)
      Yuichi Iino, Takashi Nagasima, Hirofumi Sato, Jang Moon-Sun, Suzu Oe, Yu Toyoshima, Masahiro Tomioka, Hirofumi Kunitomo, Stephen Wu, Ryo Yoshida, Yuishi Iwasaki, Takeshi Ishihara
    • Organizer
      The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YRUF2017/AISCRIB2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 線虫 Caenorhabditis elegansの糖走性学習を生み出す神経機構2017

    • Author(s)
      陳 立峻、上岡 雄太郎、内山 千紘、片江 圭太、富岡 征大、飯野 雄一
    • Organizer
      ConBio2017(第40回日本分子生物学会年会)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Decoding chemical gradient by a simple neural circuit2016

    • Author(s)
      Yuichi Iino
    • Organizer
      17th International Symposium on Olfaction and Taste (ISOT2016)
    • Place of Presentation
      PACIFICO Yokohama(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A neural circuit for memory-dependent Na+ chemotaxis dissected in Caenorhabditis elegans2016

    • Author(s)
      Lifang WANG, Hirofumi Sato, Yohsuke Sato, Masahiro Tomioka, Hirofumi Kunitomo, Yuichi Iino
    • Organizer
      17th International Symposium on Olfaction and Taste (ISOT2016)
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 餌と個体間コミュニケーションによる線虫の行動決定の機構2016

    • Author(s)
      飯野 雄一
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      COEX(韓国・ソウル市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] TORC1 and TORC2, evolutionarily conserved signaling complexes, oppositely regulate taste associative learning2016

    • Author(s)
      Naoko Sakai, Hayao Ohno, Masahiro Tomioka, and Yuichi Iino
    • Organizer
      CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR)
    • Place of Presentation
      名古屋大学豊田講堂(愛知県・名古屋市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Search for insulin-like peptides that transmit food information in starvation learning in Caenorhabditis elegan2016

    • Author(s)
      Mai Goyashiki, Masahiro Tomioka, Yuichi Iino
    • Organizer
      第22回国際動物学会議・日本動物学会第87回大会合同大会
    • Place of Presentation
      沖縄OCC(沖縄県・宜野湾市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The evolutionarily conserved target of rapamycin (TOR) protein kinase regulates salt preference in the nematode, C. elegans2016

    • Author(s)
      Naoko Sakai, Hayao Ohno, Masahiro Tomioka, Yuichi Iino
    • Organizer
      第22回国際動物学会議・日本動物学会第87回大会合同大会
    • Place of Presentation
      沖縄OCC(沖縄県・宜野湾市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecules and the neural circuit for switching the chemosensory behavior in C. elegans2016

    • Author(s)
      Yuichi Iino
    • Organizer
      NSF-AMED Workshop: Comparative Principles of Brain Architecture and Functions
    • Place of Presentation
      Marriott Marquis San Diego Marina, San Diego,U.S.A.
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification of genes involved in the pheromone signaling that regulates olfactory plasticity2016

    • Author(s)
      TORIYABE Hiroshi, YAMADA Koji, SAWAMURA Yoshiyuki, IINO Yuichi
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] C. elegansの嗅覚可塑性にはsignal-induced proliferation-associated proteinホモログSIPA-1が必要である2015

    • Author(s)
      土屋純一、山田康嗣、飯野雄一
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第83回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 線虫C. elegansのオスが異性の存在に依存して行う連合学習機構の解析2015

    • Author(s)
      大橋 智彦、酒井 奈緒子、大野 速雄、岩田 遼、飯野 雄一
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of genes involved in the pheromone signaling that regulates olfactory plasticity2015

    • Author(s)
      TORIYABE Hiroshi, YAMADA Koji, SAWAMURA Yoshiyuki, IINO Yuichi
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第86回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Molecular and Neural Circuit Mechanisms for Experience-Dependent Modulation of Chemotaxis2015

    • Author(s)
      Yuichi Iino
    • Organizer
      Gordon Research Conference "Modulation of Neural Circuits & Behavior"
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2015-06-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Identification of genes involved in the pheromone signaling that regulates olfactory plasticity in C. elegans2014

    • Author(s)
      Toriyabe H
    • Organizer
      11th International Congress of Neuroethology and 36th Annual Meeting of The Japanese Society for Comparative Physiology and Biochemistry
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2014-07-29
    • Related Report
      2014 Annual Research Report
  • [Book] 生きものたちをつなぐ「かおり」(第2章3.個体間の相互作用による線虫の匂いや味の嗜好性の変化)2016

    • Author(s)
      山田康嗣、酒井奈緒子、飯野雄一
    • Total Pages
      214
    • Publisher
      フレグランスジャーナル
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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