Molecular neural mechanisms for behavioral modulation by inter-individual communication

• Project/Area Number: 26291069
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Animal physiology/Animal behavior
• Research Institution: The University of Tokyo
• Principal Investigator: IINO YUICHI 東京大学, 大学院理学系研究科(理学部), 教授 (40192471)
• Co-Investigator(Renkei-kenkyūsha): KUNITOMO Hirofumi 東京大学, 大学院理学系研究科, 准教授 (20302812) ; TOMIOKA Masahiro 東京大学, 大学院理学系研究科, 助教 (40466800) ; TOYOSHIMA Yu 東京大学, 大学院理学系研究科, 助教 (10632341)
• Research Collaborator: TSUCHIYA Jun-ichi 東京大学, 大学院理学系研究科, 大学院生 ; TORIYABE Hiroshi 東京大学, 大学院理学系研究科, 大学院生 ; YANAGI Shuichi 東京大学, 大学院理学系研究科, 大学院生
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000); Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 異性間相互作用 / 個体群密度 / 嗅覚可塑性 / 線虫C. elegans / フェロモン / インスリンシグナル伝達経路 / 塩走性学習 / 線虫C.elegans

Outline of Final Research Achievements

To identify molecular mechanisms for inter-individual communication, we looked at the role of insulin pathway in the sexual learning. Also, we identified the role of TGF beta pathway in pheromone-dependent gene expression.

Research Products

• [Journal Article] The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans (2017)
  • Author(s): Sakai Naoko、Ohno Hayao、Tomioka Masahiro、Iino Yuichi
  • Journal Title: PLOS ONE Volume: 12 Issue: 5 Pages: e0177900-e0177900
  • DOI: 10.1371/journal.pone.0177900
  • Peer Reviewed / Open Access
• [Journal Article] Luqin-like RYamide peptides regulate food-evoked responses in C. elegans (2017)
  • Author(s): Ohno H, Yoshida M, Sato T, Kato J, Miyazato M, Kojima M, Ida T, Iino Y
  • Journal Title: Elife Volume: 6. pii Pages: 1-23
  • DOI: 10.7554/elife.28877
  • Peer Reviewed / Open Access
• [Journal Article] A Gustatory Neural Circuit of Caenorhabditis elegans Generates Memory-Dependent Behaviors in Na(+) Chemotaxis. (2017)
  • Author(s): Lifang Wang, Hirofumi Sato, Yohsuke Satoh, Masahiro Tomioka, Hirofumi Kunitomo and Yuichi Iino
  • Journal Title: J Neurosci Volume: 37 Issue: 8 Pages: 2097-2111
  • DOI: 10.1523/jneurosci.1774-16.2017
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Accurate Automatic Detection of Densely Distributed Cell Nuclei in 3D Space. (2016)
  • Author(s): Toyoshima Y, Tokunaga T, Hirose O, Kanamori M, Teramoto T, Jang MS, Kuge S, Ishihara T, Yoshida R, Iino Y.
  • Journal Title: PLoS Comput Biol. Volume: 12 Issue: 6 Pages: 1-20
  • DOI: 10.1371/journal.pcbi.1004970
  • Peer Reviewed / Open Access
• [Journal Article] Splicing factors control C. elegans behavioural learning in a single neuron by producing DAF-2c receptor. (2016)
  • Author(s): Masahiro Tomioka, Yasuki Naito, Hidehito KUROYANAGI, and Yuichi Iino.
  • Journal Title: Nature Communications Volume: - Issue: 1 Pages: 11645-11645
  • DOI: 10.1038/ncomms11645
  • NAID: 120006348540
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Optogenetic activation of axon guidance receptors controls direction of neurite outgrowth (2016)
  • Author(s): Endo, M., Hattori,M., Toriyabe, H., Ohno, H., Kamiguchi, H., Iino, Y. and Ozawa, T.
  • Journal Title: Sci. Rep. Volume: 6 Issue: 1 Pages: 23976-23976
  • DOI: 10.1038/srep23976
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Modulation of different behavioral components by neuropeptide and dopamine signalings in non-associative odor learning of Caenorhabditis elegans. (2015)
  • Author(s): Yamazoe-Umemoto, A.;Fujita, K.;Iino, Y.;Iwasaki, Y.;Kimura, K. D.
  • Journal Title: Neurosci Res Volume: 99 Pages: 22-33
  • DOI: 10.1016/j.neures.2015.05.009
  • Peer Reviewed
• [Journal Article] Structural basis for Na+ transport mechanism by a light-driven Na+ pump (2015)
  • Author(s): H. E. Kato, K. Inoue, R. Abe-Yoshizumi, Y. Kato, H. Ono, M. Konno, S. Hososhima, T. Ishizuka, M. R. Hoque, H. Kunitomo, J. Ito, S. Yoshizawa, K. Yamashita, M. Takemoto, T. Nishizawa, R. Taniguchi, K. Kogure, A. D. Maturana, Y. Iino, H. Yawo, R. Ishitani, H. Kandori*, O. Nureki*
  • Journal Title: Nature Volume: 未定 Issue: 7550 Pages: 48-53
  • DOI: 10.1038/nature14322
  • Peer Reviewed / Open Access
• [Journal Article] A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi (2015)
  • Author(s): Hamakawa M, Uozumi T, Ueda N, Iino Y & Hirotsu T
  • Journal Title: BMC Biology Volume: 13 Issue: 1 Pages: 6-6
  • DOI: 10.1186/s12915-015-0114-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 個体間相互作用による線虫の匂いや味の嗜好性の変化 (2015)
  • Author(s): 飯野雄一
  • Journal Title: エコロジカルボラタイルズ 生態系を紡ぐアロマ Volume: xx
• [Journal Article] Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans (2014)
  • Author(s): Ohno H, Kato S, Naito Y, Kunitomo H, Tomioka M, Iino Y.
  • Journal Title: Science Volume: 345 Issue: 6194 Pages: 313-7
  • DOI: 10.1126/science.1250709
  • Peer Reviewed
• [Journal Article] 異性のいる環境が忘れられない？－線虫の異性学習－ (2014)
  • Author(s): 酒井奈緒子・飯野雄一
  • Journal Title: Aroma Research Volume: 15 Pages: 142-143
• [Presentation] CeRYamides, members of the conserved RYamide peptide family, mediate food responses after fasting in C. elegans (2017)
  • Author(s): Hayao Ohno, Morikatsu Yoshida, Takahiro Sato, Johji Kato, Mikiya Miyazato, Masayasu Kojima, Takanori Ida & Yuichi Iino
  • Organizer: 16th TMIMS International Symposium
  • Invited
• [Presentation] Neural mechanisms for sugar chemotaxis learning in Caenorhabditis elegans. (2017)
  • Author(s): Risshun Chin, Yutaro Ueoka, Chihiro Uchiyama, Keita Katae, Masahiro Tomioka, Yuichi Iino
  • Organizer: 21st International C. elegans Meeting
  • Int'l Joint Research
• [Presentation] The Analysis of function of TORC2 Signaling Pathway in Associative Learning in Caenorhabditis elegans (2017)
  • Author(s): N. Sakai, H. Ohno, M. Tomioka, Y. Iino
  • Organizer: 21st International C. elegans Meeting
  • Int'l Joint Research
• [Presentation] How taste preference is modulated in the nematode (2017)
  • Author(s): Yuichi Iino, Takashi Nagasima, Hirofumi Sato, Jang Moon-Sun, Suzu Oe, Yu Toyoshima, Masahiro Tomioka, Hirofumi Kunitomo, Stephen Wu, Ryo Yoshida, Yuishi Iwasaki, Takeshi Ishihara
  • Organizer: The 16th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YRUF2017/AISCRIB2017)
  • Int'l Joint Research
• [Presentation] 線虫 Caenorhabditis elegansの糖走性学習を生み出す神経機構 (2017)
  • Author(s): 陳 立峻、上岡 雄太郎、内山 千紘、片江 圭太、富岡 征大、飯野 雄一
  • Organizer: ConBio2017(第40回日本分子生物学会年会)
• [Presentation] Decoding chemical gradient by a simple neural circuit (2016)
  • Author(s): Yuichi Iino
  • Organizer: 17th International Symposium on Olfaction and Taste (ISOT2016)
  • Place of Presentation: PACIFICO Yokohama（神奈川県・横浜市）
  • Int'l Joint Research / Invited
• [Presentation] A neural circuit for memory-dependent Na+ chemotaxis dissected in Caenorhabditis elegans (2016)
  • Author(s): Lifang WANG, Hirofumi Sato, Yohsuke Sato, Masahiro Tomioka, Hirofumi Kunitomo, Yuichi Iino
  • Organizer: 17th International Symposium on Olfaction and Taste (ISOT2016)
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Int'l Joint Research
• [Presentation] 餌と個体間コミュニケーションによる線虫の行動決定の機構 (2016)
  • Author(s): 飯野 雄一
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: COEX(韓国・ソウル市）
  • Invited
• [Presentation] TORC1 and TORC2, evolutionarily conserved signaling complexes, oppositely regulate taste associative learning (2016)
  • Author(s): Naoko Sakai, Hayao Ohno, Masahiro Tomioka, and Yuichi Iino
  • Organizer: CeNeuro2016 (C. elegans Topic Meeting: NEURONAL DEVELOPMENT, SYNAPTIC FUNCTION & BEHAVIOR)
  • Place of Presentation: 名古屋大学豊田講堂（愛知県・名古屋市）
  • Int'l Joint Research
• [Presentation] Search for insulin-like peptides that transmit food information in starvation learning in Caenorhabditis elegan (2016)
  • Author(s): Mai Goyashiki, Masahiro Tomioka, Yuichi Iino
  • Organizer: 第22回国際動物学会議・日本動物学会第87回大会合同大会
  • Place of Presentation: 沖縄OCC（沖縄県・宜野湾市）
  • Int'l Joint Research
• [Presentation] The evolutionarily conserved target of rapamycin (TOR) protein kinase regulates salt preference in the nematode, C. elegans (2016)
  • Author(s): Naoko Sakai, Hayao Ohno, Masahiro Tomioka, Yuichi Iino
  • Organizer: 第22回国際動物学会議・日本動物学会第87回大会合同大会
  • Place of Presentation: 沖縄OCC（沖縄県・宜野湾市）
  • Int'l Joint Research
• [Presentation] Molecules and the neural circuit for switching the chemosensory behavior in C. elegans (2016)
  • Author(s): Yuichi Iino
  • Organizer: NSF-AMED Workshop: Comparative Principles of Brain Architecture and Functions
  • Place of Presentation: Marriott Marquis San Diego Marina, San Diego,U.S.A.
  • Int'l Joint Research / Invited
• [Presentation] Identification of genes involved in the pheromone signaling that regulates olfactory plasticity (2016)
  • Author(s): TORIYABE Hiroshi, YAMADA Koji, SAWAMURA Yoshiyuki, IINO Yuichi
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
• [Presentation] C. elegansの嗅覚可塑性にはsignal-induced proliferation-associated proteinホモログSIPA-1が必要である (2015)
  • Author(s): 土屋純一、山田康嗣、飯野雄一
  • Organizer: BMB2015（第38回日本分子生物学会年会、第83回日本生化学会大会 合同大会）
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] 線虫C. elegansのオスが異性の存在に依存して行う連合学習機構の解析 (2015)
  • Author(s): 大橋 智彦、酒井 奈緒子、大野 速雄、岩田 遼、飯野 雄一
  • Organizer: BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会）
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] Identification of genes involved in the pheromone signaling that regulates olfactory plasticity (2015)
  • Author(s): TORIYABE Hiroshi, YAMADA Koji, SAWAMURA Yoshiyuki, IINO Yuichi
  • Organizer: BMB2015（第38回日本分子生物学会年会、第86回日本生化学会大会 合同大会）
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] Molecular and Neural Circuit Mechanisms for Experience-Dependent Modulation of Chemotaxis (2015)
  • Author(s): Yuichi Iino
  • Organizer: Gordon Research Conference "Modulation of Neural Circuits & Behavior"
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2015-06-21
  • Int'l Joint Research / Invited
• [Presentation] Identification of genes involved in the pheromone signaling that regulates olfactory plasticity in C. elegans (2014)
  • Author(s): Toriyabe H
  • Organizer: 11th International Congress of Neuroethology and 36th Annual Meeting of The Japanese Society for Comparative Physiology and Biochemistry
  • Place of Presentation: 札幌コンベンションセンター（札幌市）
  • Year and Date: 2014-07-29
• [Book] 生きものたちをつなぐ「かおり」（第2章3.個体間の相互作用による線虫の匂いや味の嗜好性の変化） (2016)
  • Author(s): 山田康嗣、酒井奈緒子、飯野雄一
  • Total Pages: 214
  • Publisher: フレグランスジャーナル