| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
We have identified a transcriptional repressors for gluconeogenic enzymes and intracellular polysaccharide synthase in the hyperthermophilic archaeon, Thermococcus kodakarensis. A transcriptional activator, Tar, may control the entire aromatic amino acid biosynthesis systems in this organism. A collaborative research with Ehime University conducted a three dimensional structural analysis of Tar. It was suggested that the novel Lrp/AsnC family transcriptional repressor is involved in the control of a asparaginase gene, with a possibility of a dynamic binding/dissociation mechanism with DNA. By genetic recombination of the transcriptional regulatory system of T. kodakarensis, strains which produce hydrogen with higher efficiency were developed.
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