| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Using recombinant Escherichia coli, the fermentative production of the useful C4 key compound was examined. For this purpose, a novel biosynthetic pathway of the useful C4 key compound was designed, and then the enzymes catalyzing each reaction step were introduced into same E. coli cells. Furthermore, the gene disruption of the host E. coli cells and the optimization of fermentation were also examined.
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