Three-dimensional structure and functionof ABC transporter responsible for macromolecule transport in bacteria
| Project/Area Number |
26292044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
橋本 渉 京都大学, (連合)農学研究科(研究院), 教授 (30273519)
丸山 如江 摂南大学, 理工学部, 助教 (90397563)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | ABCトランスポーター / X線結晶構造 / 基質結合タンパク質 / ＡＢＣタンパク質 / アルギン酸 / 体腔 / スフィンゴモナス属細菌 / ABCタンパク質 / 透過酵素 / Ｘ線結晶構造 / 酸性多糖輸送 / Sphingomonas / 輸送体分子進化 / Spingomonas / X線結晶構造解析 / フラジェリン / 鉄輸送体 |
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| Outline of Final Research Achievements |
The ABC transporter in gram negative bacterium Sphingomonas sp. A1 functions, under the cooperation with substrate-binding protein ptesent in periplasm, in the transport of macromolecules such as alginate present in milieu into cytoplasm, Through the X ray analysis, we have succeeded in the determination of the complex of ABC transporter and substrate-binding protein, and almost completely solved the molecularmechanism of the transport and its biological significans in microorganisms.
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Report
(4 results)
Research Products
(20 results)
