Functional plasticity in E. coli ribosome
| Project/Area Number |
26292048
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | National Institute of Advanced Industrial Science and Technology |
|---|
Principal Investigator |
Miyazaki Kentaro 国立研究開発法人産業技術総合研究所, 生物プロセス研究部門, 研究グループ長 (60344123)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
|
|---|
| Keywords | リボソーム / 16S rRNA / 中立進化 / キメラ遺伝子 / 機能相補 / 応用微生物 / 進化 / バイオテクノロジー / 適応進化 / 宿主 / 機能改変 / 応用微生物学 / 水平伝播 |
|---|
| Outline of Final Research Achievements |
Using E. coli null mutant of run operons, we have succeeded in obtaining functional 16S rRNA genes from various bacteria, including those from Acidobacteria, Firmicutes, and Bacteroidetes phylum, that are distantly related to E. coli. The unexpected functional plasticity in the E. coli ribosome suggest that the 16S rRNA genes have evolved by accumulating lineage-specific functionally nearly neutral evolution.
|
Report
(4 results)
Research Products
(35 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] リボソーム進化工学2015
Author(s)
宮崎健太郎
Organizer
進化分子工学研究会
Place of Presentation
千葉工業大学（千葉県習志野市）
Year and Date
2015-11-20
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
