| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
Circadian clocks are intrinsic and entrainable mechanisms that generate biological rhythms with approximately 24-hours period. Resetting of circadian clocks play an essential role in order to synchronize phases of the biological rhythm with changes in diurnal day and night cycles. Light and changes in ambient temperature are two fundamental resetting cues. Focused on time-of-day-specific temperature effect on clock gene responses, it was found that PRR9, PRR7 & LNK1 are up-regulated in response to changes in temperatures specifically at late night phase. On the contrary, TOC1 is up-regulated response to changes in temperatures specifically at early night phase. These results suggest that the temperature-response is gated by circadian clock. Chromatin immunoprecipitation assays showed that PRR9, PRR7, LNK1 and LUX are direct targets of the nighttime repressor, suggesting that temperature signals feed into the clock transcriptional circuitry through the EC nighttime repressor.
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