| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
Total synthetic studies on two potent cytotoxicns, amphidinolide N and nigricanoside A) were conducted with the intention of promoting their chemical biological studies. The synthesis of the C17-C29 fragment of the former natural product was accomplished by developing an efficient one-pot THF ring-forming processs. The southeastern segment of the latter was also prepared by exploiting the Evans asymmetric alkylation as a key step. The total synthesis of two natural oxylipins, the structures of which are similar to the oxylipin units incorporated in nigricanoside A, were also achieved and provided some important information useful for the total synthesis of nigricanoside A.
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