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Elucidation of biosynthetic pathways towards tetrodotoxin and saxitoxin based on the structures of novel biosynthetic intermediates

Research Project

Project/Area Number 26292057
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Bioorganic chemistry
Research InstitutionTohoku University

Principal Investigator

Yamashita Mari  東北大学, (連合)農学研究科(研究院), 教授 (50192430)

Co-Investigator(Renkei-kenkyūsha) NISHIKAWA TOSHIO  名古屋大学, 大学院生命農学研究科, 教授 (90208158)
NAGASAWA KAZUO  東京農工大学, 大学院工学研究院, 教授 (10247223)
KONOKI KEIICHI  東北大学, 大学院農学研究科, 准教授 (40292825)
CHO YUKO  東北大学, 大学院農学研究科, 助教 (60323086)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywordsテトロドトキシン / サキシトキシン / 生合成 / LC/MS / 中間体 / グアニジン / 構造決定 / LC-MS
Outline of Final Research Achievements

We reported the first C10-C5 directly bonded tetrodotoxin (TTX) analogues from newts, and proposed monoterpene origin of TTX. In this study, five novel bicyclic guanidine compounds related to TTX were isolated and their structures were determined. These structures strongly supported monoterpene origin of TTX.
Although biosynthetic genes corresponding to production of STX had been reported, chemical study of intermediates were not enough. In this study, Int-A', Int-C'2, and CyclicC' were chemically synthesized, and identified in toxin producing cyanobacterium and dinoflagellate using high resolution LC-MS/MS. In addition, incorporation experiments with 15N labeled these intermediates indicated that Int-A' and Int-C'2 are genuine precursors of STX analogues and Cyclic C' is a shunt compound. This is the first shunt pathway in STX biosynthesis ever found.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (100 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (4 results) Journal Article (31 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 31 results,  Open Access: 8 results,  Acknowledgement Compliant: 18 results) Presentation (59 results) (of which Int'l Joint Research: 10 results,  Invited: 7 results) Book (2 results) Remarks (4 results)

  • [Int'l Joint Research] Institute of Legal Medicine/University of Frankfurt/-(Germany)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Facultad de Bioquimica,Quimica,Farmacia/Universidad Nacional de Tucuma'n/-(アルゼンチン)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Institute of Legal Medicine/University of Frankfurt(Germany)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Facultad de Bioquimica, Quimica Farmacia/Universidad Nacional de Tucuma´n(アルゼンチン)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A new sarasinoside congener, sarasinoside M2, from a marine sponge collected in the Solomon Islands2017

    • Author(s)
      Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, and Mari Yotsu-Yamashita*
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 81 Issue: 2 Pages: 222-225

    • DOI

      10.1080/09168451.2016.1246172

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B,2017

    • Author(s)
      Tadaaki Tsukamoto, Yukie Chiba, Atsuo Nakazaki, Yuki Ishikawa, Yoshiki Nakane, Yuko Cho, Mari Yotsu-Yamashita, Toshio Nishikawa, Minoru Wakamori, and Keiichi Konoki,*
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Issue: 5 Pages: 1247-1251

    • DOI

      10.1016/j.bmcl.2017.01.054

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and identification of key biosynthetic intermediates for formation of the tricyclic skeleton of saxitoxin2017

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Renpei Yoshioka, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, and Mari Yotsu-Yamashita
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 56 Issue: 19 Pages: 1-6

    • DOI

      10.1002/anie.201612461

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthetic route towards saxitoxin and shunt pathway2016

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima and Mari Yotsu-Yamashita
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 20340-20340

    • DOI

      10.1038/srep20340

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The praying mantis (Mantodea) as predator of the poisonous red-spotted newt Notophthalmus viridescens (Amphibia: Urodela: Salamandridae)2016

    • Author(s)
      Dietrich Mebs*, Mari Yotsu-Yamashita and Osamu Arakawa
    • Journal Title

      Chemoecology

      Volume: - Issue: 3 Pages: 121-126

    • DOI

      10.1007/s00049-016-0211-3

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Spectroscopic and structural investigation on intermediates species structurally associated to the tricyclic bisguanidine compound and to the toxic agent, saxitoxin2016

    • Author(s)
      Davide Romani, Shigeki Tsuchiya, Mari Yotsu-Yamashita, Silvia A. Brandon*
    • Journal Title

      Journal of Molecular Structure

      Volume: 1119 Pages: 25-38

    • DOI

      10.1016/j.molstruc.2016.04.039

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cyclic Guanidine Compounds From Newts Support the Hypothesis that Tetrodotoxin is Derived From Monoterpene2016

    • Author(s)
      Yuta Kudo, Takeshi Yasumoto, Dietrich Mebs, Yuko Cho, Keiichi Konoki, and Mari Yotsu-Yamashita*
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55 Issue: 30 Pages: 8728-8731

    • DOI

      10.1002/ange.201602971

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of Carbon Chain Length in Acyl Coenzyme A on the Efficiency of Enzymatic Transformation of Okadaic Acid to 7-O-Acyl Okadaic Acid2016

    • Author(s)
      Sachie Furumochi, Tatsuya Onoda, Yuko Cho, Haruhiko Fuwa, Makoto Sasaki, Mari Yotsu-Yamashita, Keiichi Konoki
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 26 Issue: 13 Pages: 2992-2996

    • DOI

      10.1016/j.bmcl.2016.05.027

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The voltage-gated sodium ion channel inhibitory activities of a new tetrodotoxin analogue, 4,4a-anhydrotetrodotoxin, and three other analogues evaluated by colorimetric cell-based assay2016

    • Author(s)
      Shogo Saruhashi, Keiichi Konoki, and Mari Yotsu-Yamashita*
    • Journal Title

      Toxicon

      Volume: 119 Pages: 72-76

    • DOI

      10.1016/j.toxicon.2016.05.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of Crambescin A-C Carboxylic Acids and Their Inhibitory Activity on Voltage-Gated Sodium Channels.2016

    • Author(s)
      Nakazaki, A.; Nakane, Y.; Ishikawa, Y.; Yotsu-Yamashita, M.; Nishikawa, T.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 14 Issue: 23 Pages: 5304-5309

    • DOI

      10.1039/c6ob00914j

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Two Cytochrome P450 Monooxygenases Catalyze Early Hydroxylation Steps in the Potato Steroid Glycoalkaloid Biosynthetic Pathway2016

    • Author(s)
      Naoyuki Umemoto*, Masaru Nakayasu, Kiyoshi Ohyama, Mari Yotsu-Yamashita, Masaharu Mizutani, Hikaru Seki, Kazuki Saito, and Toshiya Muranaka
    • Journal Title

      Plant Physiol.

      Volume: 171 Issue: 4 Pages: 2458-2467

    • DOI

      10.1104/pp.16.00137

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of 11-Saxitoxinethanoic Acid and Evaluation of its Inhibitory Activity on Voltage-gated Sodium Channels2016

    • Author(s)
      Chao Wang, Mana Oki, Toru Nishikawa, Daisuke Harada, Mari Yotsu-Yamashita and Kazuo Nagasawa
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55 Issue: 38 Pages: 11600-11603

    • DOI

      10.1002/anie.201604155

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Diastereoselective Ring-Closing Metathesis as a Means to Construct Medium-Sized Cyclic Ethers: Application to the Synthesis of a Photoactivatable Gambierol Derivative2016

    • Author(s)
      Yu Onodera, Kazuaki Hirota, Yuto Suga, Keiichi Konoki, Mari Yotsu-Yamashita, Makoto Sasaki, and Haruhiko Fuwa*
    • Journal Title

      J. Org. Chem.

      Volume: 81 Issue: 18 Pages: 8234-8252

    • DOI

      10.1021/acs.joc.6b01302

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Column switching combined with hydrophilic interaction chromatography-tandem mass spectrometry for the analysis of saxitoxin analogues, and their biosynthetic intermediates in dinoflagellates2016

    • Author(s)
      Yuko Cho*, Shigeki Tsuchiya, Renpei Yoshioka, Takuo Omura, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita
    • Journal Title

      Journal of Chromatography A

      Volume: 1474 Pages: 109-120

    • DOI

      10.1016/j.chroma.2016.10.065

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tetrodotoxin concentrations in rough-skinned newts,;Taricha granulosa, from populations of their northern distribution range.2016

    • Author(s)
      Mebs, D.,* M. Yotsu-Yamashita, J. Ream, B. K. Zajac & R. Zehner
    • Journal Title

      Salamandra

      Volume: 52 Pages: 255-260

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cyclic Guanidine Compounds From Newts Support the Hypothesis that Tetrodotoxin is Derived From Monoterpene2016

    • Author(s)
      Yuta Kudo, Takeshi Yasumoto, Dietrich Mebs, Yuko Cho, Keiichi Konoki, and Mari Yotsu-Yamashita*
    • Journal Title

      Angewandte Chemie

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Identification of okadaic acid binding protein 2 in reconstituted sponge cell clusters from Halichondria okadai and its contribution to the detoxification of okadaic acid.2015

    • Author(s)
      Keiichi Konoki*, Kayo Okada, Mami Kohama, Hiroki Matsuura, Kaori Saito, Yuko Cho, Goh Nishitani, Tomofumi Miyamoto, Seketsu Fukuzawa, Kazuo Tachibana, Mari Yotsu-Yamashita
    • Journal Title

      Toxicon

      Volume: 108 Pages: 38-45

    • DOI

      10.1016/j.toxicon.2015.09.026

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The presence of 12β-deoxydecarbamoylsaxitoxin in the Japanese toxic dinoflagellate Alexandrium determined by simultaneous analysis for paralytic shellfish toxins using HILIC-LC-MS/MS2015

    • Author(s)
      Yuko Cho*, Shigeki Tsuchiya, Renpei Yoshioka, Takuo Omura, Keiichi Konoki, Yasukatsu Oshima and Mari Yotsu-Yamashita
    • Journal Title

      Harmful Algae

      Volume: 49 Pages: 58-67

    • DOI

      10.1016/j.hal.2015.09.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tetrodotoxin and its Analogues in the Pufferfish Arothron hispidus and A. nigropunctatus from the Solomon Islands: A Comparison of their Toxin Profiles with the Same Species from Okinawa, Japan2015

    • Author(s)
      Clyde Gorapava Puilingi, Yuta Kudo, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
    • Journal Title

      Toxins

      Volume: 7 Issue: 9 Pages: 3436-3454

    • DOI

      10.3390/toxins7093436

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS.2015

    • Author(s)
      Kudo, Y., Chiba, C., Konoki, K., Cho, Y. and Yotsu-Yamashita, M.
    • Journal Title

      Toxicon

      Volume: 101 Pages: 101-105

    • DOI

      10.1016/j.toxicon.2015.05.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a tricyclic bisguanidine compound structurally related to saxitoxin and its identification in paralytic shellfish toxins-producing microorganisms2015

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima and Mari Yotsu-Yamashita
    • Journal Title

      Chem. Eur. J.

      Volume: 21 Issue: 21 Pages: 7835-7840

    • DOI

      10.1002/chem.201500064

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Blocking Effects of 4,9-Anhydrotetrodotoxin, Purified from a Crude Mixture of Tetrodotoxin Analogues, on NaV1.6, Channels and Its Chemical Aspects2015

    • Author(s)
      Noriyoshi Teramoto* and Mari Yotsu-Yamashita
    • Journal Title

      Marine Drugs

      Volume: 13 Issue: 2 Pages: 984-995

    • DOI

      10.3390/md13020984

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity2014

    • Author(s)
      K. Konoki, Y. Suga, H. Fuwa, M. Yotsu-Yamashita, M. Sasaki
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 3 Pages: 514-518

    • DOI

      10.1016/j.bmcl.2014.12.022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C5-C10 Directly Bonded Tetrodotoxin Analogues: Possible Biosynthetic Precursors of Tetrodotoxin From Newts2014

    • Author(s)
      Yuta Kudo, Yoko Yamashita, Dietrich Mebs, Yuko Cho, Keiichi Konoki, Takeshi Yasumoto, Mari Yotsu-Yamashita
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 53 Issue: 52 Pages: 14546-14549

    • DOI

      10.1002/anie.201408913

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synthesis of 5- and 8-Deoxytetrodotoxin.2014

    • Author(s)
      Satake, Y.; Adachi, M.; Tokoro, S.; Yotsu-Yamashita, M.; Isobe, M.; Nishikawa, T.
    • Journal Title

      Chem. Asian. J.

      Volume: 9 Issue: 7 Pages: 1922-1932

    • DOI

      10.1002/asia.201402202

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of recombinant alpha and beta tubulins from the yew Taxus cuspidata and analysis of the microtubule assembly in the presence of taxol2014

    • Author(s)
      Yuma Kudo, Akihiro Abe, Kumiko Ito, Yuko Cho, Mari Yotsu-Yamashita & Keiichi Konoki
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 78 Issue: 11 Pages: 1887-1894

    • DOI

      10.1080/09168451.2014.940837

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and identification of proposed biosynthetic intermediates of saxitoxin in the cyanobacterium Anabaena circinalis (TA04) and the binoflagellate Alexandrium tamarense (Axat-2)2014

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima and Mari Yotsu- Yamashita
    • Journal Title

      Org. Biomol. Chem.

      Volume: 12 Issue: 19 Pages: 3016-3020

    • DOI

      10.1039/c4ob00071d

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of 6-Deoxytetrodotoxin from the Pufferfish, Takifugu pardalis, and a Comparison of the Effects of the C-6 and C-11 Hydroxy Groups of Tetrodotoxin on Its Activity2014

    • Author(s)
      Yuta Kudo, Julian Finn, Kohei Fukushima, Satsuki Sakugawa, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita
    • Journal Title

      Journal of Natural products

      Volume: 77 Issue: 4 Pages: 1000-1004

    • DOI

      10.1021/np401097n

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.2014

    • Author(s)
      Mori T, Hidaka M, Ikuji H, Yoshizawa I, Toyohara H, Okuda T, Uchida C, Asano T, Yotsu-Yamashita M, Uchida T
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 78 Issue: 5 Pages: 832-838

    • DOI

      10.1080/09168451.2014.905189

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of 5-fluoro-2’-deoxyuridine on toxin production and cell cycle regulation in marine dinoflagellate, Alexandrium tamarense2014

    • Author(s)
      Yuko Cho*, Motoo Ogawa, Mari Yotsu-Yamashita, and Yasukatsu Oshima
    • Journal Title

      Harmful Algae

      Volume: 32 Pages: 64-72

    • DOI

      10.1016/j.hal.2013.12.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channel.2014

    • Author(s)
      Nakazaki, A.; Ishikawa, Y.; Sawayama, Y.; Yotsu-Yamashita, M.; Nishikawa, T.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 12 Issue: 1 Pages: 53-56

    • DOI

      10.1039/c3ob42017e

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 渦鞭毛藻Alexandrium tamarense有毒、無毒株比較研究、推定STX生合成酵素SxtAの免疫化学的手法によるタンパク発現解析2017

    • Author(s)
      ○長 由扶子・土屋成輝・日出間志寿 大村卓朗・小池一彦・及川 寛・此木敬一・大島泰克・山下まり
    • Organizer
      平成29年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都品川区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] モヨウフグ(Arothron)属3種およびオキナワフグ(Chelonodon patoca)血漿中のテトロドトキシン類とPSTBP類似タンパク質の解析2017

    • Author(s)
      長岡佑真、村本光二、長由扶子、此木敬一、○山下まり
    • Organizer
      平成29年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学品川キャンパス(東京都品川区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 記憶喪失性貝毒ドウモイ酸新規関連化合物の探索2017

    • Author(s)
      ○海老根 優香理、小瀧 裕一、寺田 竜太、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2017
    • Place of Presentation
      京都女子大(京都府京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 有毒藍藻 Anabaena circinalis(TA04)からの未知麻痺性貝毒サキシトキシン類縁体の探索2017

    • Author(s)
      ○美野輪 高之、長 由扶子、土屋 成輝、此木 敬一、大島 泰克、山下 まり
    • Organizer
      日本農芸化学会大会2017
    • Place of Presentation
      京都女子大(京都府京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] フグにおける新規テトロドトキシン関連化合物の探索2017

    • Author(s)
      ○上山 望、杉本 敬太、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2017
    • Place of Presentation
      京都女子大(京都府京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] クロイソカイメン共生菌が生産する新規有毒二次代謝産物の探索2017

    • Author(s)
      ○菊池 颯、岡田 華弥、長 由扶子、山下 まり、此木 敬一
    • Organizer
      日本農芸化学会大会2017
    • Place of Presentation
      京都女子大(京都府京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ベラトリジンによる電位依存性ナトリウムチャネルの不活性化遅延作用に対するクランベシンB類縁体の抑制効果2017

    • Author(s)
      ○塚本匡顕、千葉雪絵、中崎敦夫、石川裕生、中根嘉祈、長由扶子、西川俊夫、山下まり、此木敬一
    • Organizer
      ベラトリジンによる電位依存性ナトリウムチャネルの不活性化遅延作用に対するクランベシンB類縁体の抑制効果
    • Place of Presentation
      京都女子大(京都府京都市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Prediction of biosynthetic pathways of tetrodotoxin and saxitoxin on the basis of the structures of their intermediates2016

    • Author(s)
      ○Mari Yotsu-Yamashita, Yuta Kudo, Shigeki Tsuchiya, Yuko Cho, and Keiichi Konoki
    • Organizer
      8th US-Japan symposium 21st century innovations in Natural Products
    • Place of Presentation
      University of Hawaii Cancer center, Hawaii Honolulu USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 麻痺性貝毒生合成中間体の同定と生合成経路の解明2016

    • Author(s)
      ○土屋成輝, 長由扶子, 吉岡廉平, 美野輪高之,此木敬一, 長澤和夫, 大島泰克, 山下まり
    • Organizer
      第58回天然有機化合物討論会
    • Place of Presentation
      東北大学百周年記念会館川内萩ホール(宮城県仙台市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] A new sarasinoside from marine sponge Melophlus sarasinorum collected in the Solomon Islands2016

    • Author(s)
      ○Clyde Gorapava Puilingi, Yuta Kudo, Keiichi Konoki, Yuko Cho and Mari Yotsu-Yamashita
    • Organizer
      Tohoku University Campus Asia Summer School
    • Place of Presentation
      東北大学理学研究科(宮城県仙台市)
    • Year and Date
      2016-08-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening of the biosynthetic intermediates of paralytic shellfish toxins using stable isotope-labeled precursors2016

    • Author(s)
      ○Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, and Mari Yotsu-Yamashita
    • Organizer
      Tohoku University Campus Asia Summer School
    • Place of Presentation
      東北大学理学研究科(宮城県仙台市)
    • Year and Date
      2016-08-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 電位依存性ナトリウムチャネルに対するテトロドトキシンおよび類縁体の阻害活性評価2016

    • Author(s)
      塚本匡顕・千葉雪絵・安立昌篤・榊原 良・所 聖太・今津拓也・佐竹佳樹・;長 由扶子・西川俊夫・山下まり・◯此木敬一
    • Organizer
      化学生態学研究会
    • Place of Presentation
      北海道函館市
    • Year and Date
      2016-07-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Screening of bioactive compounds in pufferfish and marine invertebrates from Solomon Islands2016

    • Author(s)
      Clyde Gorapava PUILING, Yuta KUDO, Yuko CHO, Keiichi KONOKI, Mari YOTSU-YAMASHITA
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規麻痺性貝毒生合成関連化合物の同定2016

    • Author(s)
      土屋 成輝、長 由扶子、吉岡 廉平、此木 敬一、長澤 和夫、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] テトロドトキシンの生合成経路解明を目指した有毒イモリからの推定生合成中間体の探索2016

    • Author(s)
      工藤 雄大、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 11-oxoTTXをハプテンとしたポリクローナル抗体の作製とTTX誘導体の生理活性2016

    • Author(s)
      猿橋 祥吾、長 由扶子、此木 敬一、西川 俊夫、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] フグから得られた新規テトロドトキシン関連化合物の単離と構造2016

    • Author(s)
      上山 望、工藤 雄大、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] トラフグ属 (Takifugu) 以外の属のフグ血漿中のPSTBP類似タンパク質の解析2016

    • Author(s)
      長岡 佑真、長 由扶子、此木 敬一、山下 まり、
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 電位依存性ナトリウムチャネルに対するテトロドトキシンおよび類縁体の阻害活性評価2016

    • Author(s)
      塚本匡顕、千葉雪絵、安立昌篤、榊原 良、所 聖太、今津拓也、佐竹佳樹、長 由扶子、西川俊夫、山下まり、此木敬一
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有毒藍藻の細胞破砕液を用いた新規麻痺性貝毒生合成中間体の探索2016

    • Author(s)
      美野輪 高之、土屋 成輝、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会大会2016
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 渦鞭毛藻Alexandrium tamarense有毒、無毒株比較研究、推定STX生合成酵素SxtAの免疫化学的手法によるタンパク発現解析2016

    • Author(s)
      長 由扶子、日出間志寿、土屋成輝、此木敬一、大島泰克、山下まり
    • Organizer
      平成28年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学(東京都品川区)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] コモンフグ卵巣由来の4,4a-anhydrotetrodotoxinの同定と生理活性2016

    • Author(s)
      猿橋祥吾 ○山下まり 長由扶子 此木敬一
    • Organizer
      平成28年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学(東京都品川区)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 痢性貝毒変換酵素の精製を目指した酵素活性測定法の開発2016

    • Author(s)
      古用幸愛,小野田竜也,長 由扶子,山下まり,此木敬一
    • Organizer
      平成28年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学(東京都品川区)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 化学的アプローチによるサキシトキシンとテトロドトキシンの生合成研究2016

    • Author(s)
      山下まり
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」地区ミニシンポジウム
    • Place of Presentation
      東京農工大学(東京都小金井市)
    • Year and Date
      2016-03-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 新規麻痺性貝毒生合成関連化合物の合成と同定2016

    • Author(s)
      ○土屋成輝、長由扶子、吉岡廉平、此木敬一、長澤和夫、大島泰克、山下まり
    • Organizer
      第27回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 麻痺性貝毒生合成経路及び生合成中間体の排出経路の推定2016

    • Author(s)
      土屋 成輝, 長 由扶子, 此木 敬一, 長澤 和夫, 大島 泰克, 山下 まり
    • Organizer
      第63回トキシンシンポジウム
    • Place of Presentation
      山形県天童市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] トラフグ属(Takifugu)以外の属のフグ血漿中のPSTBP類似タンパク質2016

    • Author(s)
      ○長岡 佑真、村本 光二、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会東北支部第151回大会
    • Place of Presentation
      山形大学農学部(山形県鶴岡市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Our recent studies of tetrodotoxin, saxitoxin and polycavernosides2015

    • Author(s)
      ○Mari Yotsu-Yamashita, Yuta Kudo, Shigeki Tsuchiya, Kosuke Maeta, Yuko Cho, Keiichi Konoki
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      ホノルルマリオットホテル(アメリカ合衆国、ホノルル市)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Study of the biosynthesis of paralytic shellfish toxins using stable isotope labeled intermediates and LC-MS2015

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa, Yasukatsu Oshima, Mari Yotsu-Yamashita
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      ハワイコンベンションセンター(アメリカ合衆国、ホノルル市)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The simultaneous analysis of saxitoxin analogues and their biosynthetic intermediates by HILIC-LC-MS/MS2015

    • Author(s)
      Cho, Yuko; Yoshioka, Renpei; Tsuchiya, Shigeki; Konoki, Keiichi; Oshima, Yasukatsu; Yotsu-Yamashita, Mari
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      ハワイコンベンションセンター(アメリカ合衆国、ホノルル市)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening and structure elucidation of the possible biosynthetic intermediates of tetrodotoxin from the newts2015

    • Author(s)
      Yuta Kudo, Yuko Cho, Keiichi Konoki and Mari Yotsu-Yamashita
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      ホノルルマリオットホテル(アメリカ合衆国、ホノルル市)
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 海洋生物毒の生合成経路への化学的アプローチ2015

    • Author(s)
      山下まり
    • Organizer
      豊橋技科大学、平成27年度 第4回 講演会
    • Place of Presentation
      豊橋技科大学(愛知県豊橋市)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 過去に致死性食中毒を引き起こした原因海藻および海藻付着物中のポリカバノシド類の分析2015

    • Author(s)
      遠藤嵩英、前田高輔、長由扶子、此木敬一、○山下まり、
    • Organizer
      日本農芸化学会東北支部第150回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] イモリにおけるテトロドトキシンの起源および蓄積能の調査と考察2015

    • Author(s)
      工藤雄大、千葉親文、長由扶子、此木敬一、山下まり
    • Organizer
      日本農芸化学会東北支部第150回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 電位依存性ナトリウムチャネルに対するテトロドトキシンおよび類縁体の活性阻害評価2015

    • Author(s)
      塚本匡顕、千葉雪絵、長 由扶子、安立昌篤、榊原 良、所 聖太、今津拓也、中崎敦夫、石川裕生、西川俊夫、山下まり、此木敬一
    • Organizer
      日本農芸化学会東北支部第150回大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有毒イモリから得られた新規環状グアニジン化合物群とテトロドトキシン生合成経路の考察2015

    • Author(s)
      工藤 雄大、千葉 親文、長 由扶子、此木 敬一、山下 まり
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      神奈川県民会館(神奈川県横浜市)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of analogues and biosynthetic intermediates of tetrodotoxin aimed at elucidating its biosynthesis2015

    • Author(s)
      Yuta Kudo, Yoko Yamashita, Yuko Cho, Keiichi Konoki and Yotsu-Yamashita Mari
    • Organizer
      Campus Aisa
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Tetrodotoxin study in pufferfish and screening of bioactive compounds in marine invertebrates from Solomon Islands2015

    • Author(s)
      Clyde Gorapava Puilingi, Yuta Kudo, Keiichi Konoki, Yuko Cho and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bioconversion of putative biosynthetic intermediates of paralytic shellfish toxins in the cyanobacterium Anabaena circinalis (TA04)2015

    • Author(s)
      Shigeki Tsuchiya, Yuko Cho, Keiichi Konoki, Kazuo Nagasawa and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-08-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗カロテノイド抗体の作製と評価2015

    • Author(s)
      上野美紗、野村駿、○南條光香、長由扶子、此木敬一、山下まり
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] ホタテガイ中で進行する下痢性貝毒オカダ酸の構造変換2015

    • Author(s)
      古用幸愛、小野田竜也、長由扶子、山下まり、此木敬一
    • Organizer
      日本ケミカルバイオロジー学会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 麻痺性貝毒生合成関連化合物の合成と生産生物の分析2015

    • Author(s)
      ○土屋成輝、長由扶子、此木敬一、長澤和夫、大島泰克、山下まり
    • Organizer
      第26回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-06-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 質量分析器を用いた新規テトロドトキシン類縁体の探索とその構造解析2015

    • Author(s)
      ○工藤 雄大、山下 瑤子、長 由扶子、此木 敬一、安元 健、山下 まり
    • Organizer
      第29回海洋生物活性談話会
    • Place of Presentation
      筑波大学下田臨海実験センター(静岡県下田市)
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 麻痺性貝毒生産Alexandrium tamarenseの無毒株における推定STX生合成遺伝子Aの変異について2015

    • Author(s)
      ○長由扶子、日出間志寿、土屋成輝、此木敬一、大島泰克、山下まり、
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2015-03-28 – 2015-03-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒガンフグ血漿タンパク質の各種テトロドトキシン類縁体との結合性2015

    • Author(s)
      ○山下まり、長岡佑真、山田俊一、長由扶子、此木敬一
    • Organizer
      平成27年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学
    • Year and Date
      2015-03-28 – 2015-03-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 有毒イモリからのテトロドトキシンの推定生合成中間体の探索2015

    • Author(s)
      ○工藤 雄大、長 由扶子、此木 敬一、山下 まり
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 麻痺性貝毒の予想生合成中間体E'の探索と精製2015

    • Author(s)
      ○吉岡 廉平、長 由扶子、土屋 成輝、此木 敬一、小柴 生造、大島 泰克、山下 まり
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 安定同位体標識生合成中間体を用いた麻痺性貝毒生合成研究2015

    • Author(s)
      ○土屋成輝1、長由扶子1、此木敬一1、長澤和夫2、大島泰克3、山下まり
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山市)
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of polycavernoside A in the red alga Gracilaria edulis that caused previous fatal food poisonings in Guam and Philippines2014

    • Author(s)
      ○Mari Yotsu-Yamashita1, Kosuke Maeta1, Yuki Taya1, Eri Omizu1, Takahide Endo1, Yuko Cho1, Keiichi Konoki1, Mirriam A. Cayme2, Yasuo Fukuyo3, Sherwood Hall4, Takeshi Yasumoto5,
    • Organizer
      The 16th International conference on Harmful Algae
    • Place of Presentation
      Wellington, New Zealand
    • Year and Date
      2014-10-27 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of 12β-deoxydecarbamoylsaxitoxin in the toxic marine dinoflagellate,2014

    • Author(s)
      ○Yuko Cho1, Renpei Yoshioka1, Shigeki Tsuchiya1, Keiichi Konoki1, Yasukatsu Oshima2, and Mari Yotsu-Yamashita1,
    • Organizer
      The 16th International conference on Harmful Algae
    • Place of Presentation
      Wellington, New Zealand
    • Year and Date
      2014-10-27 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 麻痺性貝毒の生合成経路解明のための藍藻Anabaena circinalis (TA04株)の培養条件等の検討2014

    • Author(s)
      ○土屋成輝、長由扶子、此木敬一、山下まり
    • Organizer
      H26年度日本農芸化学会北海道・東北合同支部大会
    • Place of Presentation
      札幌市、北海道大学農学部
    • Year and Date
      2014-09-22 – 2014-09-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] フグのSTX,TTX結合タンパク質の性状と機能の推定2014

    • Author(s)
      山下まり
    • Organizer
      平成26年度日本水産学会秋季大会シンポジウム,
    • Place of Presentation
      九州大学(箱崎キャンパス)
    • Year and Date
      2014-09-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Screening of tetrodotoxin in pufferfish from Solomon Islands2014

    • Author(s)
      ○Clyde Gorapava Puilingi, Yuta Kudo, Keiichi Konoki, Yuko Cho and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      Tohoku University, Sendai
    • Year and Date
      2014-07-24 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Screening of new tetrodotoxin analogues using HILIC-LC-MS/MS and their structure determination2014

    • Author(s)
      ○Yuta Kudo, Keiichi Konoki, Yuko Cho and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      Tohoku University, Sendai
    • Year and Date
      2014-07-24 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Study of the unknown biosynthetic intermediates for paralytic shellfish toxins2014

    • Author(s)
      ○Shigeki Tsuchiya1, Yuko Cho1, Keiichi Konoki1, Kazuo Nagasawa2 and Mari Yotsu-Yamashita
    • Organizer
      Campus Asia
    • Place of Presentation
      Tohoku University, Sendai
    • Year and Date
      2014-07-24 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Approach to elucidation of biosynthetic pathways towards tetrodotoxin and saxitoxin2014

    • Author(s)
      ○Mari Yotsu-Yamashita, Yuta Kudo, Shigeki Tsuchiya, Yuko Cho, and Keiichi Konoki,
    • Organizer
      Campus Asia
    • Place of Presentation
      Tohoku University, Sendai
    • Year and Date
      2014-07-24 – 2014-07-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Structure elucidation of 10-hemiketal-type tetrodotoxin analogues, indicative of the biosynthetic pathway2014

    • Author(s)
      ○Yuta Kudo,1 Yoko Yamashita,1 Keiichi Konoki,1 Yuko Cho,1 Takeshi Yasumoto2 and Mari Yotsu-Yamashita1,*
    • Organizer
      Gordon Research Conference, Natural Products,
    • Place of Presentation
      Proctor Academy in Andover NH United States
    • Year and Date
      2014-07-20 – 2014-07-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] オキナワシリケンイモリの新規テトロドトキシン類縁体の構造、および各種有毒イモリにおける分布2014

    • Author(s)
      ○工藤 雄大・此木 敬一・長 由扶子・山下 まり
    • Organizer
      第9回化学生態学研究会
    • Place of Presentation
      函館、湯の川プリンスホテル渚亭
    • Year and Date
      2014-06-27 – 2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 渦鞭毛藻Alexandrium tamarense有毒株における微量麻痺性貝毒類縁体の同定2014

    • Author(s)
      ○長 由扶子、吉岡廉平、土屋成輝、此木敬一、大島泰克、山下まり
    • Organizer
      第28回海洋生物活性談話会
    • Place of Presentation
      九州大学生物資源環境科学府附属水産試験所
    • Year and Date
      2014-05-10 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Book] Polycavernosides and Other Scarce New Toxins,pp857-284, in Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Third Edition,2014

    • Author(s)
      M. Carmen Louzao, Natalia Vilarino, and Mari Yotsu-Yamashita
    • Total Pages
      1198
    • Publisher
      Taylor & Francis group
    • Related Report
      2014 Annual Research Report
  • [Book] 第1項 テトロドトキシン、食品危害要因 その実態と検出法(food hazard materials-how to keep our food in safe)、第1編 検査法と精度管理 第一章ベーシック検査方法論と各方法精度管理、第3節水産毒2014

    • Author(s)
      山下まり
    • Total Pages
      521
    • Publisher
      (株)テクノシステム
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東北大学大学院農学研究科天然物生命化学分野

    • URL

      http://www.agri.tohoku.ac.jp/bukka/index-j.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] LaboratoryofBioorganicChemistryofNaturalProducts

    • URL

      http://www.agri.tohoku.ac.jp/bukka/English%20Version.htm

    • Related Report
      2016 Annual Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/about/organization/graduate/bukka/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/bukka/index-j.html

    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-16  

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