| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Our previous animal studies showed that indigestible oligosaccharides and Lactobacillus plantarum No.14 reduce allergic symptoms and obesity, respectively, whereas the cellular and molecular mechanisms remain unknown. We hypothesized that circulating exosomes are involved in the actions. The present study showed that anti-obese effect of L. plantarum No.14 is, at least in part, mediated by circulating exosomes. In addition, we found that supplementation of indigestible oligosaccharides and Lactobacillus strains alter the circulating microRNA profiles. Furthermore, we showed that intestinal organoids are useful for investigating the microRNA expression and exosome release in the intestinal epithelial cells.
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