| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Outline of Final Research Achievements |
Vitamin K is the micronutrient which is essential for blood coagulation system and bone metabolism in animals. The distribution of vitamin K is not only restricted in liver and bone, but also other organs including brain, gonadal tissues and pancreas. However, the functions of vitamin K in those tissues are remaining to be clarified. In this study, we analyzed the effect of vitamin K on insulin secretion from pancreatic beta cells. Vitamin K enhanced glucose dependent insulin secretion via the up-regulation of intracellular cAMP. Our results suggested that vitamin K regulates insulin secretion in pancreas.
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