Effect of activated vitamin K analogue on endocrine function
| Project/Area Number |
26292063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
SHIRAKAWA Hitoshi 東北大学, (連合)農学研究科(研究院), 准教授 (40206280)
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| Co-Investigator(Kenkyū-buntansha) |
駒井 三千夫 東北大学, (連合)農学研究科(研究院), 教授 (80143022)
後藤 知子 東北大学, (連合)農学研究科(研究院), 助教 (00342783)
豊水 正昭 東北大学, (連合)農学研究科(研究院), 教授 (80180199)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 栄養学 / ビタミンK / インスリン分泌 |
|---|
| Outline of Final Research Achievements |
Vitamin K is the micronutrient which is essential for blood coagulation system and bone metabolism in animals. The distribution of vitamin K is not only restricted in liver and bone, but also other organs including brain, gonadal tissues and pancreas. However, the functions of vitamin K in those tissues are remaining to be clarified. In this study, we analyzed the effect of vitamin K on insulin secretion from pancreatic beta cells. Vitamin K enhanced glucose dependent insulin secretion via the up-regulation of intracellular cAMP. Our results suggested that vitamin K regulates insulin secretion in pancreas.
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Report
(4 results)
Research Products
(36 results)
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[Book] 基礎食品学2015
Author(s)
白川仁 （池田郁夫、遠藤泰至編）
Total Pages
205
Publisher
アイ・ケイコーポレーション
Related Report
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