Signalling Mechanism of Autophagy Regulation by Nutrients and Food Components : Its Diversity and Anti-aging.
| Project/Area Number |
26292066
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤村 忍 新潟大学, 自然科学系, 准教授 (20282999)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | オートファジー / シグナリング / 抗加齢 / アミノ酸 / サーチュイン |
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| Outline of Final Research Achievements |
In order to contribute to anti-aging through autophagy regulation by nutrition, we searched nutrients, especially amino acids and antioxidants, and rice protein as a possible regulatory food factors of autophagy, and investigated their regulatory mechanisms, i.e., signaling mechanisms at the formation step of autophagosome, the transcription step, and the relationship with aging gene, SIRT1 including acetylation. These findings will give the evidence for food functions on elderly people.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial.2016
Author(s)
Hosojima M, Kaseda R, Kondo H, Fujii M, Kubota M, Watanabe R, Tanabe N, Kadowaki M, Suzuki Y, Saito A
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Journal Title
BMC Nutrition
Volume: 2
Issue: 1
Pages: 25-33
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] オートファジーと栄養の話2017
Author(s)
門脇 基二
Organizer
平成28年度第３回新潟県食品技術研究会
Place of Presentation
新潟東映ホテル、新潟市
Year and Date
2017-02-24
Related Report
Invited
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