| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
Branched-chain amino acids (BCAA) are essential amino acids in mammals. The aims of the present study were to elucidate the importance of branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex as the rate-limiting enzyme in the BCAA catabolism in vivo and diverse functions of BCAA as important factors to regulate systemic metabolism using global and conditional BCKDH kinase-knockout (BDK-KO) mice. In both global and muscle specific BDK-KO mice, plasma and muscle BCAA concentrations were significantly decreased, indicating that BCKDH complex is an important enzyme to regulate the BCAA catabolism. Furthermore, in the studies using these mice, it was suggested that BCAA play important roles in regulation of muscle protein metabolism, endurance exercise performance, and energy metabolism.
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