Physiological functions of branched-chain amino acids as regulatory factors in mammals
| Project/Area Number |
26292068
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北浦 靖之 名古屋大学, 生命農学研究科, 助教 (90442954)
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| Research Collaborator |
KADOTA Yoshihiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 分岐鎖アミノ酸 / 分岐鎖αケト酸脱水素酵素キナーゼ / 分岐鎖アミノ酸分解亢進 / コンディショナルノックアウト / マウス / 筋肉 / 脂肪組織 / 運動 / 筋線維タンパク質 / 持久力 |
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| Outline of Final Research Achievements |
Branched-chain amino acids (BCAA) are essential amino acids in mammals. The aims of the present study were to elucidate the importance of branched-chain alpha-ketoacid dehydrogenase (BCKDH) complex as the rate-limiting enzyme in the BCAA catabolism in vivo and diverse functions of BCAA as important factors to regulate systemic metabolism using global and conditional BCKDH kinase-knockout (BDK-KO) mice. In both global and muscle specific BDK-KO mice, plasma and muscle BCAA concentrations were significantly decreased, indicating that BCKDH complex is an important enzyme to regulate the BCAA catabolism. Furthermore, in the studies using these mice, it was suggested that BCAA play important roles in regulation of muscle protein metabolism, endurance exercise performance, and energy metabolism.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.2017
Author(s)
Ishikawa T, Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, Shimomura Y.
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Journal Title
Sci Rep.
Volume: 7
Issue: 1
Pages: 39825-39825
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle.2014
Author(s)
Y. Hatazawa, M. Tadaishi, Y. Nagaike, A. Morita, Y. Ogawa, O. Ezaki, T. Takai-Igarashi, Y. Kitaura, Y. Shimomura, Y. Kamei*, S. Miura*
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Journal Title
PLOS ONE
Volume: 9
Issue: 3
Pages: e91006-e91006
DOI
Related Report
Peer Reviewed / Open Access
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