Early protein restriction impacts gene/protein expression and function in mature brain
| Project/Area Number |
26292071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
立川 正憲 東北大学, 薬学研究科(研究院), 准教授 (00401810)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | タンパク質栄養 / 発達期栄養 / 脳機能 / 精神疾患 / 遺伝子発現 / 血液脳関門 / 発達期低栄養 / タンパク質 / アミノ酸 / 脳神経疾患 / 食品 / 分子栄養学 / 栄養学 |
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| Outline of Final Research Achievements |
This study aimed to elucidate the molecular basis by which low protein nutrition during the developmental stage leads to alterations in brain function at adult stages. Epidemiological studies have indicated that severe protein-energy malnutrition during gestational and neonatal stages increases risk of acquiring various diseases including psychiatric diseases at mature stages, but the molecular mechanisms underlying changes in brain functions have barely been elucidated. In this study, we analyzed changes in molecular expression and function in the brain at adult stages of F1 generation individuals grown by feeding a protein-restricted diet to mothers during pregnancy to lactation. We found that exposure to the low protein nutritional state elicited altered expression of plasma membrane transporters in brain vascular cells constituting the blood brain barrier, and a large scale gene expression change in the prefrontal cortex, which exhibited remarkable sexual dimorphism.
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Report
(4 results)
Research Products
(13 results)
