| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
This study aimed to elucidate the molecular basis by which low protein nutrition during the developmental stage leads to alterations in brain function at adult stages. Epidemiological studies have indicated that severe protein-energy malnutrition during gestational and neonatal stages increases risk of acquiring various diseases including psychiatric diseases at mature stages, but the molecular mechanisms underlying changes in brain functions have barely been elucidated. In this study, we analyzed changes in molecular expression and function in the brain at adult stages of F1 generation individuals grown by feeding a protein-restricted diet to mothers during pregnancy to lactation. We found that exposure to the low protein nutritional state elicited altered expression of plasma membrane transporters in brain vascular cells constituting the blood brain barrier, and a large scale gene expression change in the prefrontal cortex, which exhibited remarkable sexual dimorphism.
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