Studies on molecular mechanism of gonadal sex differentiation and its application for aquaculture in Nile tilapia
| Project/Area Number |
26292109
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Aquatic life science
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| Research Institution | Hokkaido University |
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Principal Investigator |
IJIRI SHIGEHO 北海道大学, 水産科学研究院, 准教授 (90425421)
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| Co-Investigator(Kenkyū-buntansha) |
小林 亨 静岡県立大学, 食品栄養科学部, 教授 (30221972)
足立 伸次 北海道大学, 水産科学研究院, 教授 (40231930)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Keywords | ティラピア / 性分化 / 性統御 / アロマターゼ / 濾胞刺激ホルモン / gsdf |
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| Outline of Final Research Achievements |
This study developed DNA makers which enable to select genetic male Nile tilapia. Using DNA maker, YY females were produced, resulting establishment of a method to produce all YY population. This method enable stable production of all male population as industrial useful level. In the tilapia ovarian differentiation, roles of fsh signal seemed limited and linear signaling through foxl2, cyp19a1a and estrogen production seemed sufficient signal for triggering ovarian differentiation. In the testicular differentiation, gsdf was not suggested to locate below dmrt1 signal. The fact that gsdf seemed not to affect estrogen production pathway may suggest tilapia sex differentiating factor have a role to inhibit estrogen synthesis pathway, which resulted in gsdf and dmrt1 expression that lead to trigger the testicular differentiation.
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Report
(5 results)
Research Products
(14 results)
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[Presentation] The in vivo effects of estradiol and 11-ketotestosterone on vitellogenin physiology in the shortfinned eel, Anguilla australis2018
Author(s)
Thomson-Laing, G., Damsteegt, E.L., Nagata, J., Ijiri, S., Adachi, S., Todo, T., Hiramatsu, N., Lokman, P.M.
Organizer
11th International symposium on reproductive physiology of fish. 3-8 June, 2018. Manaus Brazil
Related Report
Int'l Joint Research
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[Presentation] Amh, a necessary gene for male differentiation but not sufficient for sex determination in all the Nile tilapia populations?2017
Author(s)
Baroiller JF, Sissao R, Barbarini M, Dugue R, Cochet C, Canonne M, Toguyeni A, Melard R, Ijiri S, D’Cotta H.
Organizer
18th International Congress of Comparative Endocrinology
Place of Presentation
Chateau Lake Louise, Lake Louise, Canada
Year and Date
2017-06-04
Related Report
Int'l Joint Research
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