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Study of ion transporters involved in acclimation of teleost fishes to fresh water and seawater

Research Project

Project/Area Number 26292113
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Aquatic life science
Research InstitutionTokyo Institute of Technology

Principal Investigator

Kato Akira  東京工業大学, バイオ研究基盤支援総合センター, 准教授 (40311336)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywordsイオン輸送体 / 真骨魚 / 淡水順応 / 海水順応 / 水電解質代謝 / 上皮輸送 / 腎臓 / 比較生理学 / 魚類生理学 / イオントランスポーター / 電気生理学 / 淡水適応 / 海水適応 / 輸送上皮細胞 / 体液ホメオスタシス
Outline of Final Research Achievements

The genome of teleost fishes encodes more than a thousand of membrane transport proteins such as transporters, channels, and pumps. Some of these transporters are expressed in the epithelia of the gill, intestine, and kidney and are responsible for the osmoregulation and the body-fluid homeostasis of teleost fishes in fresh water and seawater environments. However, the activities of these transporters are not well characterized in vitro. In the present study, we analyzed the function of these transporters by using electrophysiological techniques to clarify novel branchial and renal mechanisms for the freshwater and seawater acclimation.

Report

(4 results)
  • 2017 Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] Mayo Clinic College of Medicine/University of Texas/Florida Atlantic University(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Mayo Clinic College of Medicine(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Glasgow(United Kingdom)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Na+/H+-exchange via the Drosophila vesicular glutamate transporter (DVGLUT) mediates activity-induced acid efflux from presynaptic terminals2017

    • Author(s)
      Rossano AJ, Kato A, Minard KI, Romero MF, Macleod GT
    • Journal Title

      J Physiol

      Volume: 595 Issue: 3 Pages: 805-824

    • DOI

      10.1113/jp273105

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Sulfate transporters involved in sulfate secretion in the kidney are localized in the renal proximal tubule II of the elephant fish (Callorhinchus milii).2016

    • Author(s)
      Hasegawa, K., Kato, A., Watanabe, T., Takagi, W., Romero, M., Bell, J.D., Toop, T., Donald, J.A. and Hyodo, S
    • Journal Title

      American journal of physiology. Regulatory, integrative and comparative physiology

      Volume: 311 Issue: 1 Pages: 66-78

    • DOI

      10.1152/ajpregu.00477.2015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Duplicated CFTR isoforms in eels diverged in regulatory structures and osmoregulatory functions2016

    • Author(s)
      Wong MK, Pipil S, Kato A, Takei Y
    • Journal Title

      Comp Biochem Physiol A Mol Integr Physiol

      Volume: 199 Pages: 130-141

    • DOI

      10.1016/j.cbpa.2016.06.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of Mg2+ transporters involved in magnesium homeostasis2015

    • Author(s)
      加藤 明
    • Journal Title

      生化学

      Volume: 87 Issue: 6 Pages: 727-732

    • DOI

      10.14952/SEIKAGAKU.2015.870727

    • NAID

      40020687397

    • ISSN
      0037-1017
    • Year and Date
      2015-12-25
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities2015

    • Author(s)
      Venkateswara R Chintapalli, Akira Kato, Louise Henderson, Taku Hirata, Debra J Woods, Gayle Overend, Shireen A Davies, Michael F Romero, Julian AT Dow
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 112 Issue: 37 Pages: 11720-11725

    • DOI

      10.1073/pnas.1508031112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 1.Identification and lateral membrane localization of cyclin M3, likely to be involved in renal Mg2+ handling in seawater fish2014

    • Author(s)
      Islam Z, Hayashi N, Inoue H, Umezawa T, Kimura Y, Doi H, Romero MF, Hirose S, Kato A
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 307 Issue: 5 Pages: R525-R537

    • DOI

      10.1152/ajpregu.00032.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Gene expression analysis of osmoregulatory tissues in pufferfishes acclimated to fresh water, brackish water, and seawater2017

    • Author(s)
      Kato A, Suzuki Y
    • Organizer
      Advanced Genome Science International Symposium The Start of New Genomics
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2017-01-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diversity of magnesium transporters involved in magnesium homeostasis2016

    • Author(s)
      Kato A
    • Organizer
      The 11th TOIN International Symposium on Biomedical Engineering
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 海水魚腎臓に発現するマグネシウムイオン輸送体2014

    • Author(s)
      Islam Z, Hayashi N, Romero MF, Hirose S, Kato A
    • Organizer
      日本動物学会 第85回 仙台大会
    • Place of Presentation
      東北大学、仙台
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ion transporters in the kidney of euryhaline and seawater puffer fishes2014

    • Author(s)
      Kato A
    • Organizer
      11th International Congress on the Biology of Fish
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      2014-08-04
    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京工業大学 バイオ研究基盤支援総合センター 研究部門 加藤研究室

    • URL

      http://kato.bio.titech.ac.jp/index.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2022-02-16  

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