Evaluation method for quality the farm animal egg: Based on the molecular mechanism of follicle selection
| Project/Area Number |
26292136
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Osaka International University (2015-2017)
The University of Tokyo (2014) |
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Principal Investigator |
MANABE Noboru 大阪国際大学, その他部局等, 教授 (80243070)
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| Co-Investigator(Kenkyū-buntansha) |
奥田 潔 帯広畜産大学, その他部局等, 学長 (40177168)
宮野 隆 神戸大学, 農学研究科, 教授 (80200195)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 家畜 / 卵巣 / 卵胞 / 顆粒層細胞 / アポトーシス / 細胞死阻害因子 / 卵子品質 / 卵胞閉鎖 / 畜産学 / 家畜繁殖学 / 卵子 / 阻害因子 / 品質評価 / 卵子（卵母細胞）品質 / 卵胞顆粒層細胞 / 発現制御 / 卵子（卵母細胞）の品質評価 / 卵巣内潜在的卵子 |
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| Outline of Final Research Achievements |
Less than 1% of several hundreds of thousand primordial follicles, which include primary oocytes, in livestock ovary leads to ovulation, and the rest to selectively disappear by atresia. Many endocrinologic studies have been performed to reveal the follicular selection, but the follicle selection mechanism has been unknown. We have shown that intracellular signaling pathway of cell death ligand-receptor system that regulates follicle granulosa cell apoptosis is the key to control the follicle selection.
In the present project, the factors in this signaling pathway, especially cell death signaling inhibitors, were precisely examined. We indicated that the signal inhibitors are involved in dominant factor to control the follicle selection, and that they are useful as an indicator of oocyte quality estimation.
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Report
(5 results)
Research Products
(104 results)
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[Journal Article] Evidence for a PGF2α auto-amplification system in the endometrium in mares2016
Author(s)
Keisuke Kozai, Shota Tokuyama, Anna Z Szostek, Yuko Toishi, Nobuo Tsunoda, Kazuyoshi Taya, Miki Sakatani, Masashi Takahashi, Yasuo Nambo, Dariusz J Skarzynski, Yuki Yamamoto, Koji Kimura, Kiyoshi Okuda
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Journal Title
Reproduction
Volume: 151
Issue: 5
Pages: 517-526
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Calreticulin is required for development of the cumulus oocyte complex and female fertility.2015
Author(s)
Tokuhiro K, Satouh Y, Nozawa K, Isotani A, Fujihara Y, Hirashima Y, Matsumura H, Takumi K, Miyano T, Okabe M, Benham AM, Ikawa M.
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Journal Title
Sci Rep.
Volume: 5
Issue: 1
Pages: 14254-14254
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The role of endometrial selectins and their ligands on bovine conceptus attachment to the uterine epithelium during peri-implantation period2015
Author(s)
Bai R, Kusama K, Sakurai T, Bai H, Wang C, Zhang J, Kuse M, Ideta A, Aoyagi Y, Okuda K, Imakawa K
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Journal Title
Biol Reprod
Volume: 93
Issue: 2
Pages: 46-50
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hallmarks of hepatitis C virus in equine hepacivirus2014
Author(s)
6.Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kaori Okuyama-Dobashi, Jun Yasumoto, Shinya Maekawa, Nobuyuki Enomoto, Toru Okamoto, Yoshiharu Matsuura, Masami Morimatsu, Noboru Manabe, Kazuhiko Ochiai, Kazuto Yamashita, Kohji Moriishi
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Journal Title
Journal of Virology
Volume: 88
Pages: 13352-13366
Related Report
Peer Reviewed / Open Access
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[Presentation] High expression of decoy receptor-3 in granulosa cells of Mangalica pig2015
Author(s)
Noboru Manabe, Keiichi Sezaki, József Rátky, Takashi Nagai, Kazuhiro Kikuchi, Kennich Ra, Tatsuo Ra
Organizer
The 3rd International Conference on Fatty Pig: Science and Utilization of Fatty Pig Breeds
Place of Presentation
Research Institute for Animal Breeding and Nutrition, Herceghalom, Budapest, Hungary
Year and Date
2015-11-18
Related Report
Int'l Joint Research / Invited
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[Presentation] Native pig breeds in focus of reproductive research2014
Author(s)
Rattky J, Egerszegi I, Keonuchan S, Brussow K, Taku Nagai, Kazuhiro Kikuchi, Tamas Somfai, Noboru Manabe
Organizer
International Symposium “Preservation and Utilization of Indigenous Breeds and Their Usage in Pigs”
Place of Presentation
北海道
Year and Date
2014-08-24 – 2014-08-25
Related Report
Invited
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[Book] Agricultural implications of the Fukushima nuclear accident the first three years (Chapter 8. Effects of “Clean feeding” management on livestock products contaminated with radioactive cesium due to the Fukushima Daiichi nuclear power plant accident)2016
Author(s)
Noboru Manabe, Tomotsugu Takahashi, Maiko Endo, Junyou Li, Tetsuya Tanaka, Hiroshi Kokado, Minoru Ohta, Keitaro Tanoi, Tomoko Nakanishi
Total Pages
263
Publisher
Springer, Heidelberg, Germany
Related Report
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[Book] Chapter 8. Effects of “Clean feeding” management on livestock products contaminated with radioactive cesium due to the Fukushima Daiichi nuclear power plant accident. Agricultural Implications of the Fukushima Nuclear Accident: The First Three Years2016
Author(s)
Noboru Manabe, Tomotsugu Takahashi, Maiko Endo, Junyou Li, Tetsuya Tanaka, Hiroshi Kokado, Minoru Ohta, Keitaro Tanoi, Tomoko Nakanishi
Total Pages
263
Publisher
Springer, Heidelberg, Germany
Related Report
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