Exploration of mechanism underlying differentiation to brown/brite adipocytes in fat depots of fattening cattle
| Project/Area Number |
26292137
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Kyoto University |
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Principal Investigator |
Matsui Tohru 京都大学, (連合)農学研究科(研究院), 教授 (40181680)
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| Co-Investigator(Kenkyū-buntansha) |
友永 省三 京都大学, (連合)農学研究科(研究院), 助教 (00552324)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 褐色脂肪細胞 / Brite細胞 / ウシ / ビタミンA / 畜産学 / 応用動物 / 生体機能利用 / ビタミンＡ |
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| Outline of Final Research Achievements |
We established culture condition to differentiate stromal-vascular cells originated from bovine adipose tissues to brite (brown in white) adipocytes. Retinoic acid had an inhibitory effect on expression of Ucp1, a gene predominantly expressed in brite adipocytes. Feeding vitamin A-restricted diet did not affect expression level in adipose tissues of Japanese Black fattening cattle. However, Ucp1 expression was slightly higher in brite adipocytes differentiated from stromal vascular cells isolated from vitamin A-restricted cattle than in those from control cattle.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Expression of uncoupling protein 1 in bovine muscle cells.2016
Author(s)
Abd Eldaim MA, Hashimoto O, Ohtsuki H, Yamada T, Murakami M, Onda K, Sato R, Kanamori Y, Qiao Y, Tomonaga S, Matsui T, Funaba M
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Journal Title
J Anim Sci.
Volume: 94
Issue: 12
Pages: 5097-5104
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Dietary regulation of Ucp2 and Ucp3 expressions in white adipose tissues of beef cattle.2016
Author(s)
Shigematsu M, Yamada T, Wong YY, Kanamori Y, Murakami M, Fujimoto Y, Suzuki M, Kida R, Qiao Y, Tomonaga S, Matsui T, Funaba M.
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Journal Title
Can J Anim Sci.
Volume: 96
Issue: 4
Pages: 457-460
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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