| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
Inflammatory bowel diseases such as ulcerative colitis or Crohn disease increase rapidly in the young Japanese recently. The cause is still unknown and becomes the big problem in the world. We studied the yogurt using the lactic acid bacteria (LAB) which remove harmful bacteria by production of antibacterial peptides or stimulate immunity until now. We studied
the adhesion of bacteria to human intestine by a biosensor Biacore and discovered "a blood type lactic acid bacterium" in human intestinal tract for the first time in the world. Using a blood type lactic acid bacterium indicating this high human intestinal tract adhesion, we could developed the new feature-related yogurt which enabled the prevention and remission by removing a pathogen and various harm bacteria of the ulcerative colitis by the competitive inhibition according to the blood type and, in this study, showed possibility to prevent illness.
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