Involvement of nociceptive channels as molecular basis of neuropathic pain development
| Project/Area Number |
26292150
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Tottori University |
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Principal Investigator |
Ohta Toshio 鳥取大学, 農学部, 教授 (20176895)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 賢次 鳥取大学, 農学部, 准教授 (00400143)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAGAWA Toshiaki 北海道大学, 理学研究科, 准教授 (20142177)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | 疼痛 / 侵害受容体 / TRPチャネル |
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| Outline of Final Research Achievements |
This study was performed to clarify regulatory mechanisms of endogenous substances and analgesic effect on TRPA1, which is mainly expressed in sensory nerves as a molecular basis of nociceptors with highly reactive to ambient temperature and irritating chemical substances. TRPA1 was activated by sulfur-containing compounds and carbonyl stress-induced products in vivo, causing a pain response. It was also found that one of the plant-derived terpenoids has an analgesic effect via the suppression of TRPA1 channel. In addition, a single amino acid was identified for the site of action of a blocking agent with a high potency against mammalian homologues by molecular biological approach utilizing species differences. These studies revealed the pathophysiological significance of the relationship between nociceptive channel and pain.
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Report
(5 results)
Research Products
(35 results)
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[Journal Article] CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.2016
Author(s)
Miyake K, Ohta T, Nakayama H, Doe N, Terao Y, Oiki E, Nagatomo I, Yamashita Y, Abe T, Nishikura K, Kumanogoh A, Hashimoto K, Kawahara Y.
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Journal Title
Cell Reports
Volume: 17
Issue: 8
Pages: 2004-2014
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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