| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
This study was performed to clarify regulatory mechanisms of endogenous substances and analgesic effect on TRPA1, which is mainly expressed in sensory nerves as a molecular basis of nociceptors with highly reactive to ambient temperature and irritating chemical substances. TRPA1 was activated by sulfur-containing compounds and carbonyl stress-induced products in vivo, causing a pain response. It was also found that one of the plant-derived terpenoids has an analgesic effect via the suppression of TRPA1 channel. In addition, a single amino acid was identified for the site of action of a blocking agent with a high potency against mammalian homologues by molecular biological approach utilizing species differences. These studies revealed the pathophysiological significance of the relationship between nociceptive channel and pain.
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