| Project/Area Number |
26292153
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Kitasato University |
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Principal Investigator |
Shinji Takai 北里大学, 獣医学部, 教授 (80137900)
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| Co-Investigator(Kenkyū-buntansha) |
角田 勤 北里大学, 獣医学部, 准教授 (80317057)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 病原性プラスミド / 細菌感染症 / 病原遺伝子 / 馬 / 毒力関連抗原遺伝子群 / pathogenicity island / 獣医学 / 感染症 / 病原細菌 / プラスミド / 毒力 / ロドコッカス・エクイ / 病原性 / 遺伝子 / 肺炎 / 網羅的解析 / ロドコッカス･エクイ / 毒力関連抗原 / 強毒株 / 化膿性肺炎 / Pathogenicity island / 病原性獲得 |
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| Outline of Final Research Achievements |
The discovery of virulence plasmids has allowed the classification of Rhodococcus equi strains and molecular epidemiological studies of virulent R. equi. At least three virulence levels of R. equi have been identified: virulent, intermediate virulence, and avirulent. Virulent R. equi is characterized by the presence of virulence-associated 15- to 17-kDa antigens (VapA), a virulence plasmid of 85 to 90 kb. VapA-positive R. equi is widespread on horse-breeding farms, but not on farms of other domestic animals. R. equi strains of intermediate virulence are identified by a virulence-associated 20-kDa antigen (VapB) and a virulence plasmid of 79 to 100 kb. The presence of a pathogenicity island is characterised by a significantly lower G+C content and analysis of the pathogenicity island resulted in six vapA homologues (vapC,D,E,F,G,H) and four vapB homologues (vapI,J,K,L). The purpose of this study is focus to find out those genes in the isolates from earth worms.
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