Novel cancer therapy for spontaneous animal tumor using ultrasound irradiation with microbubble
| Project/Area Number |
26292155
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 健介 北海道大学, (連合)獣医学研究科, 助教 (80625898)
佐々木 東 北海道大学, (連合)獣医学研究科, 助教 (00754532)
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| Co-Investigator(Renkei-kenkyūsha) |
KUDO Nobuki 北海道大学, 大学院情報科学研究科, 准教授 (30271638)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Keywords | 獣医学 / トランスレーショナルリサーチ / がん治療 / 超音波治療 / マイクロバブル / ソノポレーション / ドラッグデリバリー / がん / 膀胱がん / 甲状腺がん |
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| Outline of Final Research Achievements |
This study revealed that sonoporation, the combination of ultrasound and microbubbles, enhances the antitumor effect of a chemotherapeutic agent with minimum invasiveness in preclinical canine thyroid and bladder cancer models. Moreover, the results of this study clarified the mechanism of sonoporation. This preclinical study may contribute to establish sonoporation as a theranostic tool in cancer therapy.
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Report
(4 results)
Research Products
(9 results)
