| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
Drug resistance is a major cause of the failure in the chemotherapy for malignant tumors in dogs. In this study, comprehensive analysis of gene expression profiles revealed that immune responses and inflammatory reactions were suppressed in lymphoma tissues at the acquisition of drug resistance. In addition, a model to predict chemotherapy resistance was established using expression profiles of 6 genes associated with immune/inflammatory responses. This study revealed novel mechanisms of chemotherapy resistance and suggested that the resistance to chemotherapy could be predicted by the quantification of the 6 genes before chemotherapy. Findings obtained from this study would be beneficial for the chemotherapy in dogs and also provide useful information for the cancer chemotherapy in humans.
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