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Control of bovine viral diarrhea virus infection as a latent disease: preventive investigation for the transmission

Research Project

Project/Area Number 26292160
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionRakuno Gakuen University

Principal Investigator

Tajima Motoshi  酪農学園大学, 獣医学群, 教授 (90202168)

Co-Investigator(Kenkyū-buntansha) 高橋 俊彦  酪農学園大学, 農食環境学群, 教授 (40709771)
萩原 克郎  酪農学園大学, 獣医学群, 教授 (50295896)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2017: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords牛ウイルス性下痢ウイルス / BVDV / 持続感染牛 / PI / 持続感染 / バルク乳検査 / 子宮内感染 / 入牧検診
Outline of Final Research Achievements

In order to estimate the spread manner of bovine viral diarrhea virus (BVDV) in and among the dairy herd, epidemiological and immunological analyzes were performed for the BVDV detected and free herd discriminated by the bulk tank milk tests and the mass surveillance. The results indicated that in-uterus persistently infected fetus moved as pregnant cow with the dam among the herd, then the new prevalence was confirmed. It seemed to be important for the prevention to keep the BVDV-free status besides vaccination.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (30 results)

All 2017 2016 2015 2014

All Journal Article (11 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (15 results) (of which Int'l Joint Research: 2 results) Book (4 results)

  • [Journal Article] Increase of cells expressing PD-1 and PD-L1 and enhancement of IFN-γ production via PD-1/PD-L1 blockade in bovine mycoplasmosis2017

    • Author(s)
      Goto Shinya、Konnai Satoru、Okagawa Tomohiro、Nishimori Asami、Maekawa Naoya、Gondaira Satoshi、Higuchi Hidetoshi、Koiwa Masateru、Tajima Motoshi、Kohara Junko、Ogasawara Satoshi、Kato Yukinari、Suzuki Yasuhiko、Murata Shiro、Ohashi Kazuhiko
    • Journal Title

      Immunity, Inflammation and Disease

      Volume: 5 Issue: 3 Pages: 355-363

    • DOI

      10.1002/iid3.173

    • NAID

      120006711664

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intrauterine infection with bovine leukemia virus in pregnant dam with high viral load.2017

    • Author(s)
      Sajiki, Y., Konnai, S., Nishimori, A., Okagawa, T., Maekawa, N., Goto, S., Nagano, M., Kohara, J., Kitano, N., Takahashi, T., Tajima, M., Mekata, H., Horii, Y., Murata, S. & Ohashi, K
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 79 Pages: 2036-2039

    • NAID

      130006267604

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 北海道の公共牧場における牛消化管内寄生虫の浸潤状況と駆虫対策の実態2017

    • Author(s)
      北野 菜奈,福本 真一郎,徳山 桂理,池田 恵子,髙橋 俊彦
    • Journal Title

      家畜衛生学雑誌

      Volume: 43 Pages: 153-160

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological effects of chitosan on bovine peripheral blood mononuclear cells in vitro.2016

    • Author(s)
      Ohtsuka, H., Kamikawa,N., Tomioka, M., Maeda, Y., Hirose, K. & Tajima, M
    • Journal Title

      J. Chitin and Chitosan Sci.

      Volume: 4 Issue: 1 Pages: 74-79

    • DOI

      10.1166/jcc.2016.1106

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds2016

    • Author(s)
      Ando,T., Takino, T., Makita, K., Tajima, M., Koiwa, M. & Hagiwara,K
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 11 Pages: 1669-1672

    • DOI

      10.1292/jvms.16-0156

    • NAID

      130005170617

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of vaccination protocols for bovine herpesvirus type1 and bovine viral diarrhea virus.2015

    • Author(s)
      Kato, H., Sato,R., Oonishi, M. & Tajima, M
    • Journal Title

      J. Vet. Med. Res.

      Volume: 2 Pages: 1034-1037

    • NAID

      120006311921

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 酪農家における農場衛生モニタリング調査について2015

    • Author(s)
      古木陽子、髙橋俊彦
    • Journal Title

      繁殖技術

      Volume: 35 Pages: 32-34

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 全国の農場における衛生モニタリング調査について2015

    • Author(s)
      森脇祥江、髙橋俊彦
    • Journal Title

      繁殖技術

      Volume: 35 Pages: 66-68

    • Related Report
      2015 Annual Research Report
  • [Journal Article] BVDウイルス感染症の現状と対策2015

    • Author(s)
      田島誉士
    • Journal Title

      家畜診療

      Volume: 62 Pages: 5-10

    • NAID

      40020313863

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 牛ウイルス性下痢ウイルス持続感染牛対策とは!?2015

    • Author(s)
      田島誉士
    • Journal Title

      臨床獣医

      Volume: 33(7) Pages: 12-15

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 北海道日高地方におけるエゾシカの内部寄生虫相および道内エゾシカ寄生日本産肝蛭の分布について2014

    • Author(s)
      1.森昇子、三觜慶、鈴木瑞穂、萩原克郎、浅川満彦
    • Journal Title

      北海道獣医師会雑誌

      Volume: 58 Pages: 44-47

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] ホルスタイン種搾乳牛における前搾り乳汁の生菌数と体細胞数の量的推移,2017

    • Author(s)
      北野菜奈、菊佳男、長澤裕哉、林智人、髙橋俊彦
    • Organizer
      平成28年度日本獣医師会獣医学術学会年次大会(石川)
    • Place of Presentation
      石川県金沢
    • Year and Date
      2017-02-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 鼻粘膜ワクチンを接種した黒毛和種におけるサイトカイン動態の評価.2017

    • Author(s)
      小中一成、米山修、富田大祐、田島誉士、大塚浩通
    • Organizer
      平成28年度日本獣医師会獣医学術学会年次大会(石川)
    • Place of Presentation
      石川県金沢
    • Year and Date
      2017-02-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新たな視点からの牛ウイルス性下痢ウイルス清浄化対策法の必要性2017

    • Author(s)
      田島誉士、遠藤恭子、山本浩平、田中志奈、大塚浩通
    • Organizer
      平成29年度獣医学術地区学会(北海道)、産業動物獣医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 乾乳期乳牛への鼻腔粘膜ワクチン接種による分娩後の炎症性疾患の予防効果の検証.2017

    • Author(s)
      内倉翔真、川本哲、田島誉士、大塚浩通、加藤敏英、小岩政照
    • Organizer
      平成29年度獣医学術地区学会(北海道)、産業動物獣医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 北海道の公共牧野における消化管内線虫の浸潤状況2017

    • Author(s)
      北野菜奈、福本真一郎、髙橋俊彦
    • Organizer
      家畜衛生学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 牛ウイルス性下痢ウイルス2型の急性感染事例.2016

    • Author(s)
      吉田隆志、西村恭一、吉田美葉、田島誉士
    • Organizer
      平成28年度獣医学術地区学会(北海道)
    • Place of Presentation
      北海道旭川
    • Year and Date
      2016-09-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] Prevalence of bovine viral diarrhea virus infection in Hokkaido, Japan; epidemiological analyses based on the viral genotype2016

    • Author(s)
      Tajima, M., Nitta, A., Sawada, M., Nakamura, H. Ohtsuka, H
    • Organizer
      XXⅨ World Buiatrics Congress(第29回世界牛病学会ダブリン
    • Place of Presentation
      アイルランド、ダブリン
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of cytokine mRNA of peripheral CD4+CD8+ and gamma delta T cells between healthy Holstein and Japanese Black calves.2016

    • Author(s)
      Ohtsuka, H., Kinouchi, K. Tajima, M
    • Organizer
      XXⅨ World Buiatrics Congress(第29回世界牛病学会ダブリン
    • Place of Presentation
      アイルランド、ダブリン
    • Year and Date
      2016-07-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本における牛呼吸器感染症に関わる最近の浸潤調査2015

    • Author(s)
      中村有貴、西航司、樋口豪紀、髙橋俊彦
    • Organizer
      家畜感染種学会
    • Place of Presentation
      札幌国際ビル(札幌)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 牛ウイルス性下痢ウイルス持続感染牛発生農家を基にした感染拡大様式の分析2015

    • Author(s)
      澤田真里、中村北斗、新田温子、大塚浩通、田島誉士
    • Organizer
      平成27年度獣医学術地区学会(北海道)、産業動物獣医学会
    • Place of Presentation
      酪農学園大学(江別)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 2014年11月以降に北海道内で摘発された牛ウイルス性下痢ウイルス持続感染牛の疫学的解析2015

    • Author(s)
      新田温子、澤田真里、中村北斗、大塚浩通、田島誉士
    • Organizer
      平成27年度獣医学術地区学会(北海道)、産業動物獣医学会
    • Place of Presentation
      酪農学園大学(江別)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 乳牛におけるボルナ病ウイルス母子感染の分析疫学的相対リスク2015

    • Author(s)
      安藤達哉、小林洋平、近藤達成、蒔田浩平、田島誉士、萩原克郎、小岩政照
    • Organizer
      平成27年度獣医学術地区学会(北海道)、産業動物獣医学会
    • Place of Presentation
      酪農学園大学(江別)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 牛ウイルス性下痢ウイルス感染症の地域的な対策事例と効果の検証2015

    • Author(s)
      斎野仁、川内京子、臼井章、大野浩、田島誉士、迫田義博
    • Organizer
      平成26年度日本獣医師会獣医学術学会年次大会(岡山)
    • Place of Presentation
      岡山
    • Year and Date
      2015-02-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 牛白血病ウイルス遺伝子検出法の簡易化の検討2014

    • Author(s)
      川原雄太、田島誉士
    • Organizer
      平成26年度獣医学術地区学会(北海道)、産業動物獣医学会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Transmission of bovine viral diarrhea virus by pregnant cows; observation in a farm.2014

    • Author(s)
      Tajima, M. & Sasaki, R.
    • Organizer
      第28回世界牛病学会2014ケアンズ
    • Place of Presentation
      ケアンズ(オーストラリア)
    • Year and Date
      2014-07-28
    • Related Report
      2014 Annual Research Report
  • [Book] テレビ・ドクター 4 よくわかる乳牛の病気100選2017

    • Author(s)
      小岩政照、田島誉士監修
    • Total Pages
      234
    • Publisher
      デーリィマン社
    • ISBN
      9784864530491
    • Related Report
      2017 Annual Research Report
  • [Book] これからの乳牛群管理のためのハードヘルス学<成牛編>2017

    • Author(s)
      及川伸編著、田島誉士共著
    • Total Pages
      375
    • Publisher
      緑書房
    • ISBN
      9784895313193
    • Related Report
      2017 Annual Research Report
  • [Book] 子牛の医学2014

    • Author(s)
      田島誉士ら
    • Total Pages
      479
    • Publisher
      緑書房
    • Related Report
      2014 Annual Research Report
  • [Book] 獣医内科学大動物編第2版2014

    • Author(s)
      田島誉士ら
    • Total Pages
      416
    • Publisher
      文永堂出版
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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