Studies of performance for pituitary organogenesis and maintenance of function after tissue maturation
Project/Area Number |
26292166
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Integrative animal science
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Research Institution | Meiji University |
Principal Investigator |
Kato Yukio 明治大学, 農学部, 専任教授 (30114177)
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Co-Investigator(Renkei-kenkyūsha) |
KATO TAKAKO 明治大学, 研究・知財戦略機構, 研究推進員 (90445859)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
|
Keywords | 下垂体 / 幹細胞 / 生殖 / 分化 / 組織形成 / 転写因子 / 神経堤 / 血管形成 / 遺伝子 / 発現制御 / 内分泌学 / 細胞・組織 / 内分泌 / 発生・分化 |
Outline of Final Research Achievements |
he pituitary gland is a major endocrine organ for maintenance of vital functions. This project focuses on the characteristics of pituitary stem/progenitor cells and the roles on pituitary organogenesis and maintenance. Our studies have demonstrated following important results: 1) characteristic localizations of several specific factors, 2) isolation of one of two types of stem/progenitor cell niches, 3) demonstration of characteristic differentiation into hormone-producing and non-hormone-producing cells, 4) novel isolation of stem/progenitor cells by using anti-CD9 antibody and differentiation into vascular endothelial cell-like cells, 5) invasion of two types of the neural crest lineage cells into the anterior and posterior lobes of the pituitary gland, respectively.
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Report
(5 results)
Research Products
(111 results)
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[Journal Article] TGFbeta signaling reinforces pericyte properties of the non-endocrine mouse pituitary cell line TtT/GF.2017
Author(s)
Tsukada, T., Yoshida, S., Kito, K., Fujiwara, K., Yako, H., Horiguchi, K., Isowa, Y., Yashiro, T., Kato, T., and Kato, Y.
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Journal Title
Cell Tissue Res
Volume: 371
Pages: 339-350
Related Report
Peer Reviewed
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[Journal Article] Construction and expression of vectors encoding biologically active rodent gonadotropins2017
Author(s)
A. Ohta, Y. Tsunoda, Y. Tamura, K. Iino, N. Nishimura, H. Nishihara, H. Takanashi, S. Yoshida, T. Kato, Y. Kato.
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Journal Title
Journal of Reproduction and Development
Volume: 63
Issue: 6
Pages: 605-609
DOI
NAID
ISSN
0916-8818, 1348-4400
Related Report
Peer Reviewed / Open Access
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[Journal Article] CXCL10/CXCR3 signaling mediates inhibitory action by Interferon-Gamma on CRF-stimulated adrenocorticotropic hormone (ACTH) release.2016
Author(s)
Horiguchi K, Fujiwara K, Tsukada T, Yoshida S, Higuchi M, Tateno K, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y.
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Journal Title
Cell Tissue Res
Volume: 0
Issue: 2
Pages: 0-0
DOI
Related Report
Peer Reviewed
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[Journal Article] S100β-positive Cells of Mesenchymal Origin Reside in the Anterior Lobe of the Embryonic Pituitary Gland2016
Author(s)
Horiguchi K, Yako H, Yoshida S, Fujiwara K, Tsukada T, Kanno N, Ueharu H, Nishihara H, Kato T, Yashiro T, Kato Y
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Journal Title
PLoS ONE
Volume: 11
Issue: 10
Pages: 1-18
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Search for regulatory factors of the pituitary-specific transcription factor PROP1 gene2016
Author(s)
Nishimura N, Ueharu H, Nishihara H, Shibuya S, Yoshida S, Higuchi M, Kanno N, Horiguchi K, Kato T, Kato Y
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Journal Title
Journal of Reproduction and Development
Volume: 62
Issue: 1
Pages: 93-102
DOI
NAID
ISSN
0916-8818, 1348-4400
Related Report
Peer Reviewed / Open Access
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[Journal Article] Expression of Slug in S100β protein-positive cells of the postnatal developing rat anterior pituitary gland.2015
Author(s)
Horiguchi K, Fujiwara K, Tsukada T, Yako H, Tateno K, Hasegawa R, Takegami S, Osako S, Yashiro T, Kato T, Kato Y.
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Journal Title
Cell Tissue Res
Volume: 0
Issue: 2
Pages: 0-0
DOI
Related Report
Peer Reviewed
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[Journal Article] PRRX1- and PRRX2-positive mesenchymal stem/progenitor cells are involved in vasculogenesis during rat embryonic pituitary development.2015
Author(s)
Higuchi, M., Yoshida, S., Ueharu, H., Chen, M., Kato, T. and Kato, Y.
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Journal Title
Cell Tissue Res
Volume: 358
Issue: 2
Pages: 557-565
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] GFP-expressing S100β-positive cells of the rat anterior pituitary differentiate into hormone-producing cells.2014
Author(s)
Higuchi, M., Kanno, N., Yoshida, S., Ueharu, H., Chen, M., Yako, H., Shibuya, S., Sekita, M., Tsuda, M., Mitsuishi, H., Kato, T. and Kato, Y.
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Journal Title
Cell Tissue Res
Volume: 357
Pages: 767-779
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] PRRX1 and PRRX2 distinctively participate in pituitary organogenesis and cell supply system.2014
Author(s)
Higuchi, M., Yoshida, S., Ueharu, H., Chen, M., Kato, T. and Kato, Y.
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Journal Title
Cell Tissue Res
Volume: 357
Pages: 323-335
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Expression of chemokine CXCL10 in dendritic cell-like S100β-positive cells in rat anterior pituitary gland.2014
Author(s)
Horiguchi, K., Fujiwara, K., Higuchi, M., Yoshida, S., Tsukada, T., Ueharu, H., Hasegawa, R., Takigami, S., Ohsako, S., Yashiro, T., Kato, T. and Kato, Y.
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Journal Title
Cell Tissue Res
Volume: 357
Pages: 757-765
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Isolation of dendritic cell-like S100β-positive cells in rat anterior pituitary gland.2014
Author(s)
Horiguchi, K., Fujiwara, K., Yoshida, S., Higuchi, M., Tsukada, T., Kanno, N., Yashiro, T., Tateno, K., Osako, S., Kato, T. and Kato, Y.
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Journal Title
Cell Tissue Res
Volume: 357
Pages: 301-308
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Proton receptor GPR68 expression in dendritic cell-like S100β-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification.2014
Author(s)
Horiguchi, K., Higuchi, M., Yoshida, S., Nakakura, T., Tateno, K., Hasegawa, R., Osako, S., Kato, T. and Kato, Y.
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Journal Title
Cell Tissue Res
Volume: 358
Pages: 515-525
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Expression of kruppel-like factor 6, KLF6, in rat pituitary stem/progenitor cells and its regulation of the PRRX2 gene.2014
Author(s)
Ueharu, H., Higuchi, M., Nishimura, N., Yoshida, S., Shibuya, S., Sensui, K., Kato, T. and Kato, Y.
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Journal Title
J Reprod Dev
Volume: 60
Pages: 304-311
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Gene expression, function, and diversity of Nkx2-4 in the rainbow trout, Oncorhynchus mykiss2014
Author(s)
Uemae, Y., Sakamoto, J., Hidaka, Y., Hiratsuka, A., Susa, T., Kato, Y. and Suzuki, M.
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Journal Title
Gen Comp Endocrinol
Volume: 206
Pages: 193-202
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Characterization of murine pituitary-derived cell lines Tpit/F1, Tpit/E and TtT/GF.2014
Author(s)
Yoshida, S., Higuchi, M., Ueharu, H., Nishimura, N., Tsuda, M., Nishihara, H., Mitsuishi, H., Kato, T. and Kato, Y.
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Journal Title
J Reprod Dev
Volume: 60
Pages: 295-303
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Localization of a juxtacrine factor ephrin-B2 in the pituitary stem/progenitor cell niches throughout life.2014
Author(s)
Yoshida, S., Kato, T., Chen, M., Higuchi, M., Ueharu, H., Nishimura, N. and Kato, Y.
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Journal Title
Cell Tissue Res
Volume: 359
Pages: 755-766
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Molecular cloning of rat and porcine retina-derived POU domain factor 1 (POU6F2) from pituitary cDNA library.2014
Author(s)
Yoshida, S., Ueharu, H., Higuchi, M., Horiguchi, K., Nishimura, N., Shibuya, S., Mitsuishi, H., Kato, T. and Kato, Y.
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Journal Title
J Reprod Dev
Volume: 60
Pages: 288-294
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 下垂体前葉内濾胞星状細胞が発現するCD抗原の探索2017
Author(s)
堀口幸太郎, 吉田彩舟, 藤原研, 塚田岳大, 加藤たか子, 長谷川瑠美, 瀧上周, 大迫俊二, 屋代隆, 加藤幸雄
Organizer
第122回日本解剖学会総会・全国学術集会
Place of Presentation
九州・長崎大学坂本キャンパス
Year and Date
2017-03-28
Related Report
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[Presentation] Analysis of the differentiation capacity of adult stem/progenitor cells in the parenchymal-niche of the rodent pituitary gland.2017
Author(s)
Yoshida, S., Yurino, H., Kobayashi, M., Nishimura, N., Kanno, N., Yano, K., Hashimoto, S-i., Kato, T., Kato, Y
Organizer
The 2017 ISSCR Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Cytogenetics of Primary Amenorrhea: An Investigation on 14 Mfected.2017
Author(s)
Kondo, A., Nakaoku, D., Yamasaki, M., Morine, M., Hinokio, K., Kato, Y., Shinoda, M., Izumi, S., Maeda, K
Organizer
WCRB 2017
Related Report
Int'l Joint Research
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[Presentation] Analysis of a novel gene expressed by S100β-positive cells in the rat anterior lobe of the pituitary.2017
Author(s)
Horiguchi, K., Nakakura, T., Tsukada, T., Yoshida, S., Hasegawa, R., Takigami, S., Ohsako, S., Kato, T., Kato, Y
Organizer
WCRB 2017
Related Report
Int'l Joint Research
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[Presentation] 下重体前葉内S100タンパク質陽性細胞から分泌され るケモカインCXCL10のlFN-γ による制御.2014
Author(s)
堀口幸太郎, 吉田彩舟, 藤 原研, 樋口雅司, 塚 田岳大, 加藤たか子, 舘野こずえ, 長谷川留美, 瀧上潤, 大 迫俊二, 屋代隆、加藤幸雄.
Organizer
第40回日本神経内分泌学会学術集会
Place of Presentation
都道府県会館
Year and Date
2014-10-31 – 2014-11-02
Related Report
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[Presentation] Invasion of S100β-positive cells into pituitary gland during embryonic period.2014
Author(s)
H. Yako, K. Horiguchi, M. Higuchi, K. Fujiwara, S. Yoshida, M. Chen, N. Kanno, H. Ueharu, T. Kato, T. Yashiro and Y. Kato.
Organizer
World Congress of Reproductive Biology 2014
Place of Presentation
Edinburgh, UK
Year and Date
2014-09-02 – 2014-09-04
Related Report
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[Presentation] 樹状細胞様S100タンパク質陽性細胞から分泌されるケモカインCXCL10の機能解析.2014
Author(s)
堀口幸太郎, 吉田彩舟, 藤原研, 樋 口雅司, 塚田岳大, 加 藤たか子, 舘野こずえ, 長谷川留美, 瀧上潤, 大迫俊二, 屋 代隆、加藤幸雄.
Organizer
第29回日本下垂体研究会学術集会
Place of Presentation
八王子セミナーハウス
Year and Date
2014-08-08 – 2014-08-10
Related Report
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[Presentation] 蛍光タンパク質融合ゴナドトロピンの細胞内局在.2014
Author(s)
高梨遥, 西村直人, 西原大翔, 上 春浩貴, 樋口雅司, 吉 田彩舟, 加藤たか子、加藤幸雄.
Organizer
第29回日本下垂体研究会学術集会
Place of Presentation
八王子セミナーハウス
Year and Date
2014-08-08 – 2014-08-10
Related Report