| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
In this project, we examined the molecular mechanism that regulates synapsis and recombination of homologous chromosome as well as chromosome condensation and separation during mammalian meiosis.
We showed that meiotic cohesins are localized at the connection sites between axial and transverse filaments of the synaptonemal complex in mouse spermatocytes. We also found that ectopic expression of meiotic cohesin subunit RAD21L shortened the distance between homologous chromosomes in somatic cultured cells. Using knockout mice, we demonstrated that condensin II plays a main role in chromosome condensation and segregation during meiosis of mouse oocytes.
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