| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Profftella, an endosymbiont of the Asian citrus psyllid Diaphorina citri, appears to be an unprecedented organelle-like defensive symbiont. The present study aiming to understand its ecology, function, and evolution revealed the following: (1) bacterial populations of 40 psyllid species and genome sequences of four symbionts including an apparent sister species of Profftella; (2) behavior of Profftella during the transovarial transmission and the development of D. citri; (3) inhibitory effects of diaphorin, a polyketide produced by Profftella, against insects and yeasts; (4) distribution and concentration of diaphorin within D. citri, as well as expression of genes involved in the diaphorin synthesis during the development of D. citri; (5) antitumor activity of diaphorin.
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