| Project/Area Number |
26293002
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
OHWADA Tomohiko 東京大学, 薬学研究科(研究院), 教授 (20177025)
|
|---|
| Research Collaborator |
FIRMAN
INOMATA Satoru
ZHAI Luhan
OCAMPO Diego
OTANI Yuko
IKEDA Hirotaka
KAWAHATA Masatoshi
YAMAGUCHI Kentaro
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
|---|
| Keywords | ペプチド / 水素結合 / ヘリックス / S-NO化 / Ｓ－ニトロソ化 / プロリン / ヘリックス分子 / タンパク質の表面認識 / 薬学 / 有機化学 / アミド / トランスニトロソ化 / ニトロソアミン / 非平面化 / TRPチャネル / Ｎ－ニトロソアミン / 可視光照射 / アミド結合 / シス-トランス動的平衡 / トランス-アミド |
|---|
| Outline of Final Research Achievements |
The amide bond is a key linkage in proteins, peptides and peptide mimics, serving to connect two neighbouring amino acids or analogues. Most amide bonds are planar, but nonplanar amide structures have been suggested to occur even in proteins and peptides. Although the magnitude of nonplanarity found in proteins and peptides is not large, some nonplanar amides with distinct ground states have been reported. In such non-planar amides, the nitrogen atom gains a partial sp3-character (i.e., nitrogen-pyramidalization), and at the same time bond-twisting occurs. While hydrogen-bonding to the pyramidalized electron-rich nitrogen atom has been experimentally and computationally investigated, there has been little study on the possibility of hydrogen bonding to the electron-deficient carbonyl oxygen atom of non-planar amides. We studied hydrogen bonding of 7-azabicyclo[2.2.1]heptane amides, which are chemically stable and intrinsically nonplanar.
|
