| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
Boronated cholesterols were successfully synthesized. Using these cholesterol, high content boron liposomes were developed for new generation neutron capture therapy. A counter cation of boron ion clusters (closo-dodecaborates) was found to be essential for the encapsulation efficacy of boronated liposomes: a sperimidinium form of closo-dodecaborates was highly encapsulated into liposomes prepared from phospholipids. Furthermore, boron imaging technologies in the cells have been developed using a combination of in cell click fluorescent imaging technique and Raman imaging technology.
Biopolymer-based boron delivery system was also developed for selective and efficient delivery of boron to tumor in vivo based on the EPR effect. Maleimide-closo-dodecaborate (MID) was successfully synthesized. MID conjugated not only a free SH group of cysteine residues but also lysine residues in proteins and its serum albumin conjugates were found to be accumulated into tumor selectively.
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