Development of Boronated Cholesterols and their Highly Functionalized Nano Carriers for New Generation Neutron Capture Therapy
| Project/Area Number |
26293007
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
布施 新一郎 東京工業大学, 資源化学研究所, 准教授 (00505844)
佐藤 伸一 東京工業大学, 資源化学研究所, 助教 (20633134)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | がん治療 / イメージング / 中性子捕捉療法 / リポソーム / 生体分子 / 放射線 / 蛍光 / がん / ナノバイオ / 薬学 / ホウ素 |
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| Outline of Final Research Achievements |
Boronated cholesterols were successfully synthesized. Using these cholesterol, high content boron liposomes were developed for new generation neutron capture therapy. A counter cation of boron ion clusters (closo-dodecaborates) was found to be essential for the encapsulation efficacy of boronated liposomes: a sperimidinium form of closo-dodecaborates was highly encapsulated into liposomes prepared from phospholipids. Furthermore, boron imaging technologies in the cells have been developed using a combination of in cell click fluorescent imaging technique and Raman imaging technology.
Biopolymer-based boron delivery system was also developed for selective and efficient delivery of boron to tumor in vivo based on the EPR effect. Maleimide-closo-dodecaborate (MID) was successfully synthesized. MID conjugated not only a free SH group of cysteine residues but also lysine residues in proteins and its serum albumin conjugates were found to be accumulated into tumor selectively.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Proteomic analysis of cellular response induced by boron neutron capture reaction in human squamous cell carcinoma SAS cells2015
Author(s)
Sato A., Itoh T., Imamichi S., Kikuhara S., Fujimori H., Hirai T., Saito S., Sakurai Y., Tanaka H., Nakamura H., Suzuki M., Murakami Y., Baiseitov D., Berikkhanova K., Zhumadilov Z., Imahori Y., Itami J., Ono K., Masunaga S., Masutani M.
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Journal Title
Applied Radiation and Isotopes
Volume: 106
Pages: 113-219
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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