Understanding for Alzheimer's disease pathogenesis and the development of novel target for therapy

• Project/Area Number: 26293010
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: SUZUKI Toshiharu 北海道大学, 薬学研究科(研究院), 教授 (80179233)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: アルツハイマー病 / 老化 / 認知症 / APP / 神経変性疾患 / アミロイドβ / X11L / 神経科学 / 痴呆

Outline of Final Research Achievements

Pathogenesis of sporadic Alzheimer's disease (AD) is various. To reveal these, this research focused on (1) the function of X11 and/or X11L, and (2) mechanism to cleave substrate proteins by gamma-secretase. X11 binds to a target protein in non-phosphorylated state, while X11L associate same target in phosphorylation-mimicked state. We identified Src protein kinase as a potential kinase to phosphorylate X11L. In X11 and X11L genes double-KO mice, a micro-localization of some of neurotransmitter receptors was disturbed, which may be a cause of amyloid-beta dependent aberrant signal transduction inducing neuronal cell death. Furthermore, this research found that changes of lipid composition within cell membrane can induce altered gamma-cleavages of substrates such as APP and Alcadein. Taken together , these findings suggest a novel pathogenic way of AD and target of drug development.

Research Products

• [Int'l Joint Research] ManRos Therapeutics/University Paris-Saclay/Sorbonne University(France)
• [Int'l Joint Research] University of British Columbia(Canada)
• [Int'l Joint Research] Edith Cowan University/Hollywood Private Hospital(Australia)
• [Int'l Joint Research] Mount Sinai School of Medicine(米国)
• [Int'l Joint Research] ManRos Therapeutics(France)
• [Journal Article] Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease (2017)
  • Author(s): Chiori Omori, Rika Motodate, Yuzuha Shiraki, Kyoko Chiba, Yuriko Sobu, Ayano Kimura, Tadashi Nakaya, Hikaru Kondo, Satoshi Kurumiya, Toru Tanaka, Kazuo Yamamoto, Motowo Nakajima, Toshiharu Suzuki and Saori Hata
  • Journal Title: Nutritional neuroscience Volume: 印刷中 Issue: 9 Pages: 538-546
  • DOI: 10.1080/1028415x.2016.1199114
  • Peer Reviewed / Open Access
• [Journal Article] Expression and localization of X11 family proteins in neurons (2016)
  • Author(s): Motodate, R., Saito, Y., Hata, S., Suzuki, T.
  • Journal Title: Brain Res Volume: 1646 Pages: 227-234
  • DOI: 10.1016/j.brainres.2016.05.054
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Specific triazine herbicides induce amyloidβ42 production. (2016)
  • Author(s): Portlius E, Durieu E, Bodin M, Cam M, Pannee J, Leuxe C, Mabondzo A, Oumata N, Galons H, Lee J-Y, Chang Y-T, Stuber K, Koch P, Fontanine G, Potier M, Manouspoulou A, Garbis S, Covaci A, VanDam D, De Deyn P, Karg F, Flajolet M, Omori C, Hata S, Suzuki T, Blennow K, Zetteberg H, and Meijer L
  • Journal Title: J. Alzheimer Dis Volume: 54 Issue: 4 Pages: 1593-1605
  • DOI: 10.3233/jad-160310
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism-linked excitatory synaptic suppressor MDGA2 (2016)
  • Author(s): S. A. Connor, I. Ammendrup-Johnsen, A. W. Chan, Y. Kishimoto, C. Murayama, N. Kurihara, A. Tada, Y. Ge, H. Lu, R. Yan, J. M. LeDue, H. Matsumoto, H. Kiyonari, Y. Kirino, F. Matsuzaki, T. Suzuki, T. H. Murphy, Y. T. Wang, T. Yamamoto, A. M. Craig
  • Journal Title: Neuron Volume: 91 Issue: 5 Pages: 1052-1068
  • DOI: 10.1016/j.neuron.2016.08.016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Alternative Selection of BACE1 Cleavage Sites in APP Harboring Protective And Pathogenic Mutations Within the Aβ Sequence (2016)
  • Author(s): Kimura, A., Hata, S., Suzuki, T
  • Journal Title: J. Biol. Chem. Volume: 291 Issue: 46 Pages: 24041-24053
  • DOI: 10.1074/jbc.m116.744722
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Arachidonic Acid Diet Attenuates Aβ Deposition in Tg2576 Mice. (2015)
  • Author(s): Hosono T, Nishitsuji K, Nakamura T, Jung CG, Kontani M, Tokuda H, Kawashima H, Kiso Y, Suzuki T, Michikawa M
  • Journal Title: Brain Res Volume: 10 Pages: 1613-1629
  • DOI: 10.1016/j.brainres.2015.04.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Arachidonic or docosahexaenoic acid diet prevents memory impairment in Tg2576 mice. (2015)
  • Author(s): Hosono T, Mouri A, Nishitsuji K, Jung CG, Kontani M, Tokuda H, Kawashima H, Shibata H, Suzuki T, Nabeshima T, Michikawa M.
  • Journal Title: J Alzheimers Dis Volume: 48 Issue: 1 Pages: 149-162
  • DOI: 10.3233/jad-150341
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E (2015)
  • Author(s): Kimura, A., Hata, S., Suzuki, T.
  • Journal Title: FEBS Lett Volume: 589 Issue: 18 Pages: 2394-2400
  • DOI: 10.1016/j.febslet.2015.07.017
  • NAID: 120005828463
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage (2015)
  • Author(s): Norio Takei, Yuriko Sobu, Ayano Kimura, Satomi Urano, Yi Piao, Yoichi Araki, Hidenori Taru, Tohru Yamamoto, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
  • Journal Title: Journal of Biological Chemistry Volume: 290 Issue: 2 Pages: 987-995
  • DOI: 10.1074/jbc.m114.599852
  • Peer Reviewed / Open Access
• [Journal Article] Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease (2014)
  • Author(s): Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Moroshima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. for J-ADNI
  • Journal Title: J. Alzheimers Dis Volume: 39 Issue: 4 Pages: 861-870
  • DOI: 10.3233/jad-131610
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as as amyloid beta accumulation modifier (2014)
  • Author(s): Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
  • Journal Title: Proc. Acad. Natl. Sci. USA Volume: 111 Issue: 7 Pages: 2638-2643
  • DOI: 10.1073/pnas.1307345111
  • Peer Reviewed / Open Access
• [Journal Article] Methylglyoxal produced by amyloid β-peptide-induced nitrotyrosination of triosephoshate isomerase triggers neuronal death in Alzheimer disease. (2014)
  • Author(s): Tajes, M., Eraso-Pichot, A., Rubio-Moscardo, F., Guivernau, B., Ramos-Fernandez, E., Bosch-Morato, M., Guix, F. X., Clarimon, J., Miscione, G. P., Boada, M., Gil-Gomez, G., Suzuki, T., Molina, H., Villa-Freixa, J., Vicente, R. and Munoz, F. J.
  • Journal Title: J. Alzheimers Dis. Volume: 41 Issue: 1 Pages: 273-288
  • DOI: 10.3233/jad-131685
  • Peer Reviewed
• [Journal Article] Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer’s disease in clinical practice. (2014)
  • Author(s): Waragai, M. et al.
  • Journal Title: J. Alzheimer’s Dis. Volume: 41 Issue: 4 Pages: 1207-1222
  • DOI: 10.3233/jad-132786
  • Peer Reviewed
• [Journal Article] Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. (2014)
  • Author(s): Chiba K, Araseki M, Nozawa K, Furukori K, Araki Y, Matsushima T, Nakaya T,Hata S, Saito Y, Uchida S, Okada Y, Nairn AC, Davis RJ, Yamamoto T, Kinjo M, Taru, H, Suzuki T.
  • Journal Title: Mol Biol Cell Volume: 25 Issue: 22 Pages: 3569-3580
  • DOI: 10.1091/mbc.e14-06-1111
  • NAID: 120005522339
  • Peer Reviewed / Open Access
• [Presentation] X11 and X11L regulate the non-synaptic NMDA receptor localization. (2016)
  • Author(s): Rika Motodate, Yuhki Saito, Toshiharu Suzuki.
  • Organizer: Neuro2016
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Adaptor protein, X11 and X11L have distinct roles in exploratory activity (2016)
  • Author(s): Taisuke Sato, Rika Motodate, Yoshitake Sano, Seina Kamada Seiichi Uchida, Toshiharu Suzuki
  • Organizer: Neuro2016
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Mechanism that BACE1 alternates the cleaving sites of human APP. (2016)
  • Author(s): Toshiharu Suzuki, Ayano Kimura, Saori Hata
  • Organizer: Neuro2016
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Alternative cleavage mechanism of human BACE1 (2016)
  • Author(s): Toshiharu Suzuki, Ayano Kimura, Saori Hata
  • Organizer: AAIC2016
  • Place of Presentation: Tronto (Canada)
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Increase of p3-Alc[alpha]38 to p3-Alc[alpha]35, products of alcadein[alpha]; by[gamma]-secretase cleavage, in CSF of AD patients (2016)
  • Author(s): Chioti Omori, Saori Hata, Masaaki Waragai, Kazuo Yamamoto, Toshiharu Suzuki
  • Organizer: AAIC2016
  • Place of Presentation: Tronto (Canada)
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Aberrant micro-membrane localization of [gamma]-secretase components by changes in cellular cholesterol level alters e-and/or g-cleavage of APP and Alcadein[alpha] (2016)
  • Author(s): Hu Anqi, Yi Piao, Saori Hata, Toshiharu Suzuki
  • Organizer: AAIC2016
  • Place of Presentation: Tronto (Canada)
  • Year and Date: 2016-07-24
  • Int'l Joint Research
• [Presentation] Membrane lipid composition and γ-secretase cleavage of Alzheimer’s disease-related proteins (2015)
  • Author(s): 羽田沙緒里、朴 懿、西村正樹、鈴木利治
  • Organizer: BMB2015 (第88回日本生化学会大会、第38回日本分子生物学会年会 合同大会)
  • Place of Presentation: 神戸国際会議場 (兵庫県神戸市）
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] Analysis of APLP2 anterograde transport systems in the neuronal axon (2015)
  • Author(s): 奥村祐香1、千葉杏子1、Rojer J. Davis 2、金城政孝3、鈴木利治1
  • Organizer: BMB2015 (第88回日本生化学会大会、第38回日本分子生物学会年会 合同大会)
  • Place of Presentation: 神戸国際会議場 (兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] Analysis of JIP1b-dependent APP anterograde transport by kinesin-1 (2015)
  • Author(s): 加藤優実1、○千葉杏子1、鈴木利治1
  • Organizer: BMB2015 (第88回日本生化学会大会、第38回日本分子生物学会年会 合同大会)
  • Place of Presentation: 神戸国際会議場 (兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] Novel role of X11 and X11L in the regulation of NMDA receptor localization (2015)
  • Author(s): Rika Motodate, Yuhki Saito, Toshiharu Suzuki
  • Organizer: Neuroscience 2015
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Function and regulation of APP and Alcadeinα cargoes transported by kinesin-1 in neuron. (2015)
  • Author(s): Yuzuha Shiraki, Kyoko Chiba, Saori Hata, Toshiharu Suzuki
  • Organizer: Neuroscience 2015
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Association of Alcadein alpha with kinesin light chain is regulated by phosphorylations at cytoplasmic acidic region. (2015)
  • Author(s): Yuriko Sobu, Saori Hata, Toshiharu Suzuki
  • Organizer: Neuroscience 2015
  • Place of Presentation: McCormick Place, Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] BACE1によるAPP切断部位決定機構の解析 (2015)
  • Author(s): 木村彩乃、鈴木利治
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森 (青森県青森市）
  • Year and Date: 2015-10-02
• [Presentation] AlcadeinとX11LによるAPP代謝制御 (2015)
  • Author(s): 川原聡、後藤直也、羽田沙緒里、山本融、鈴木利治
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森 (青森県青森市）
  • Year and Date: 2015-10-02
• [Presentation] JIP1b-KLC相互作用によるAPP輸送制御 (2015)
  • Author(s): 千葉杏子、野澤啓輔、荒関雅彦、金城政孝、鈴木利治
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森 (青森県青森市）
  • Year and Date: 2015-10-02
• [Presentation] p3-Alcの検出によるγセクレター切断解析 (2015)
  • Author(s): 羽田沙緒里、大森智織、藁谷正明、鈴木利治
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森 (青森県青森市）
  • Year and Date: 2015-10-02
• [Presentation] 膜コレステロール含量に依存したγセクレターゼによる基質切断変化 (2015)
  • Author(s): Hu Anqi, Piao Yi, 羽田沙緒里、西村正樹、鈴木利治
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森 (青森県青森市）
  • Year and Date: 2015-10-02
• [Presentation] p3-Alcα分子種のアルツハイマー病バイオマーカー有用性の検証 (2015)
  • Author(s): 大森智織、羽田沙緒里、藁谷正明、前田雅弘、立花太郎、Laurent Meijer, 山本一夫、鈴木利治
  • Organizer: 第5回日本認知症予防学会学術集会
  • Place of Presentation: 神戸国際会議場 (兵庫県神戸市）
  • Year and Date: 2015-09-25
• [Presentation] 孤発性アルツハイマー病における膜マイクロドメインのγセクレターゼ活性変化 (2015)
  • Author(s): 羽田沙緒里、Piao Yi, 西村正樹、鈴木利治
  • Organizer: 第5回日本認知症予防学会学術集会
  • Place of Presentation: 神戸国際会議場 (兵庫県神戸市）
  • Year and Date: 2015-09-25
• [Presentation] nalysis of the localization of glutamate receptors in X11/X11L double-deficient mice. (2015)
  • Author(s): Rika Motodate, Yuhki Saito, Suzuki Toshiharu.
  • Organizer: 25th Meeting of the International Society for Neurochemistry
  • Place of Presentation: Cairns Congress Center, Cairns, Australia
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] Molecular mechanism of shifting the cleavage site of APP by BACE1 (2015)
  • Author(s): Ayano Kimura and Toshiharu Suzuki.
  • Organizer: 25th Meeting of the International Society for Neurochemistry
  • Place of Presentation: Cairns Congress Center, Cairns, Australia
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] Kinesin-1 Cargo Receptor APP and Alcadeina transport different type of vesicular cargo to the axonal terminal. (2015)
  • Author(s): Yuzuha Shiraki, Kyoko Chiba, Saori Hata, Toshiharu Suzuki
  • Organizer: 25th Meeting of the International Society for Neurochemistry
  • Place of Presentation: Cairns Congress Center, Cairns, Australia
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] Regulation of Alcα association with kinesin-1 by phosphorylation of Alca cytoplasmic region (2015)
  • Author(s): Yuriko Sobu, Saori Hata, Toshiharu Suzuki.
  • Organizer: 25th Meeting of the International Society for Neurochemistry
  • Place of Presentation: Cairns Congress Center, Cairns, Australia
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] egulation of axonal transport of APP cargos by kinesin-1. (2015)
  • Author(s): Toshiharu Suzuki, Kyoko Chiba, Saori Hata.
  • Organizer: 25th Meeting of the International Society for Neurochemistry
  • Place of Presentation: Cairns Congress Center, Cairns, Australia
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] 新規アルツハイマー病創薬を目指して ―基礎研究成果からの展開― (2015)
  • Author(s): 鈴木利治、西村正樹、木村彩乃、Piao Yi、羽田沙緒里
  • Organizer: 医療薬学フォーラム2015/第23回クリニカルファーマーシーシンポジウム
  • Place of Presentation: 名古屋国際会議場 (愛知県名古屋市）
  • Year and Date: 2015-07-04
  • Invited
• [Presentation] Altered cleavages of amyloid β-protein precursor and Alcadein by γ-secretase by changing membrane lipid composition: A possible cause of sporadic Alzheimer’s disease by aging. (2015)
  • Author(s): Toshiharu Suzuki.
  • Organizer: Asian Aging Core for Longevity “2006-2015, 10 years and beyond” AACL Conference
  • Place of Presentation: Osaka University Nakanoshima Center.
  • Year and Date: 2015-03-10 – 2015-03-13
  • Invited
• [Presentation] 神経細胞内のAPP軸索順行輸送制御機構とAPP代謝 シンポジウム「認知症研究におけるCell Biology II: 細胞内輸送」 (2014)
  • Author(s): 鈴木利治、千葉杏子、羽田沙緒里
  • Organizer: 第33回日本認知症学会学術集会
  • Place of Presentation: パシフィコ横浜 横浜
  • Year and Date: 2014-11-29 – 2014-12-01
  • Invited
• [Presentation] JIP1 is required for the efficient anterograde transport of APP in neuronal axon driven by kinesin-1. (2014)
  • Author(s): Yuka Okumura, Kyoko Chiba, Angus, C. Nairn, Roger J. Davis, Masataka Kinjo, Toshiharu Suzuki.
  • Organizer: Society for Neuroscience annual meeting, Neuroscience 2014
  • Place of Presentation: Washington DC Convention Center, Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Levels of CSF and plasma p3-Alcα35, a major product of alcadeina by g-secretase cleavages, in elder subjects with or without dementia (2014)
  • Author(s): Chiori Omori, Saori Hata, Toshiharu Suzuki.
  • Organizer: Society for Neuroscience annual meeting, Neuroscience 2014
  • Place of Presentation: Washington DC Convention Center, Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] BACE1によるAPPの切断部位変化の分子機構の解析 (2014)
  • Author(s): 木村 彩乃、鈴木 利治
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都会館 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] X11, X11LによるNMDA受容体活性制御機構の解析 (2014)
  • Author(s): 本館利佳、齋藤有紀、鈴木利治
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都会館 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Alcadeinα細胞質ドメインのリン酸化による機能調節 (2014)
  • Author(s): 蘇武佑里子、羽田沙緒里、鈴木利治
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都会館 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 積み荷受容体APPの神経軸索内輸送とAPP輸送小胞構成タンパク質の解析 (2014)
  • Author(s): 白木柚葉、千葉杏子、羽田沙緒里、鈴木利治
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都会館 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] 奥村祐香、千葉杏子、金城政孝、鈴木利治 (2014)
  • Author(s): 奥村祐香、千葉杏子、金城政孝、鈴木利治
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都会館 京都
  • Year and Date: 2014-10-15 – 2014-10-18
• [Presentation] Brain aging as an etiology of Alzheimer’s disease (2014)
  • Author(s): Toshiharu Suzuki
  • Organizer: Asian Aging Core for Longevity Research (AACL) 2014 Conference
  • Place of Presentation: Haevichi Hotel Conference Room, Jeju, Koria.
  • Year and Date: 2014-09-21 – 2014-09-22
  • Invited
• [Presentation] γセクレターゼによるAlcadein細胞内ドメインの産生とその機能解析 (2014)
  • Author(s): 蘇武祐里子、朴懿、羽田沙緒里、鈴木利治
  • Organizer: 第19会日本病態プロテアーゼ学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター、大阪
  • Year and Date: 2014-08-08 – 2014-08-09
• [Presentation] Regulated axonal transport of APP and alcadein by kinesin-1. (2014)
  • Author(s): Toshiharu Suzuki, Kyoko Chiba, Yuka Okumura, Yuzuha Shiraki, Masataka Kinjo, Saori Hata, Hidenori Taru.
  • Organizer: American Society for Biochemistry and Molecular Biology annual meeting 2014 (Experimental Biology 2014)
  • Place of Presentation: San Diego Convention Center, San Diego, USA
  • Year and Date: 2014-04-26 – 2014-04-30
• [Book] Aging Mechanism –Longevity, Metabolism, and Brain Aging (2015)
  • Author(s): Suzuki T., Kimura A., Chiba K., Nakaya T., Hata S
  • Total Pages: 439
  • Publisher: Springer
• [Patent(Industrial Property Rights)] アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、並びにこれらに関連する治療法および病態解析方向 (2014)
  • Inventor(s): 井上剛、鈴木利治、羽田沙緒里
  • Industrial Property Rights Holder: 井上剛、鈴木利治、羽田沙緒里
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-04-15
  • Overseas