Elucidation of regulatory mechanisms of stress signaling whose dysregulation causes inflammation and autoimmune diseases
Project/Area Number |
26293011
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
|
Keywords | ストレス / シグナル伝達 / 活性酸素 / 炎症 / 自己免疫疾患 |
Outline of Final Research Achievements |
ASK1 (Apoptosis signal-regulating kinase 1), a stress-responsive kinase, induces a variety of physiological functions including cell death and immune responses in response to various types of stress such as reactive oxygen species, and the dysregulation of ASK1 leads to various diseases including inflammation and autoimmune diseases. Therefore, the activation of ASK1 should be strictly regulated in response to stress. However, the regulatory mechanisms of ASK1 had not been completely understood. In this study, we revealed that the activation of ASK1 is fine-tuned by several ubiquitination-related molecules such as USP9X, Roquin-2, and TRIM48, which have been originally identified in our laboratory, and that the fine-tuning of ASK1 provides appropriate responses including cell death and immune responses in response to a type, intensity, and duration of stress.
|
Report
(4 results)
Research Products
(60 results)
-
-
[Journal Article] Trans-fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.2017
Author(s)
Hirata, Y., Takahashi, M., Kudoh, Y., Kano, K., Kawana, H., Makide, K., Shinoda, Y., Yabuki, Y., Fukunaga, K., Aoki, J., Noguchi, T., Matsuzawa, A.
-
Journal Title
J. Biol. Chem.
Volume: 印刷中
Issue: 20
Pages: 8174-8185
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.2017
Author(s)
Abe, T., Takahashi, M., Kano, M., Amaike, Y., Ishii, C., Maeda, K., Kudoh, Y., Morishita, T., Hosaka, T., Sasaki, T., Kodama, S., Matsuzawa, A., Kojima, H., Yoshinari, K.
-
Journal Title
Arch. Toxicol.
Volume: 印刷中
Issue: 6
Pages: 2365-2374
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] Brefeldin A-inhibited guanine nucleotide-exchange factor 1 (BIG1) governs the recruitment of tumor necrosis factor receptor-associated factor 2 (TRAF2) to tumor necrosis factor receptor 1 (TNFR1) signaling complexes.2016
Author(s)
Noguchi, T., Tsuchida, M., Kogue, Y., Spadini, C., Hirata, Y., Matsuzawa, A.
-
Journal Title
Int. J. Mol. Sci.
Volume: 17
Issue: 11
Pages: 1869-1869
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
[Journal Article] PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.2016
Author(s)
Shizu, R., Abe, T., Benoki, S., Takahashi, M., Kodama, S., Miayata, M., Matsuzawa, A., Yoshinari, K.
-
Journal Title
Biochem. J.
Volume: 473
Issue: 3
Pages: 257-266
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
[Journal Article] The DEAH-Box RNA Helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses2014
Author(s)
Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I. and Ichijo, H.
-
Journal Title
Sci. Signal.
Volume: 7
Issue: 323
DOI
Related Report
Peer Reviewed
-
[Journal Article] Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses2014
Author(s)
Maruyama, T., Araki, T., Kawarazaki, Y., Naguro, I., Heynen, S., Aza-Blanc, P., Ronai, Z., Matsuzawa, A. and Ichijo, H.
-
Journal Title
Sci. Signal.
Volume: 7
Issue: 309
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Inhibition of apoptosis signal-regulating kinase 1 enhances endochondral bone formation by increasing chondrocyte survival.2014
Author(s)
Eaton, G. J., Zhang, Q. S., Diallo, C., Matsuzawa, A., Ichijo, H., Steinbeck, M. J., Freeman, T. A.
-
Journal Title
Cell Death Dis.
Volume: 5
Issue: 11
Pages: e1522-e1522
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-