| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
The suprachiasmatic nucleus (SCN), the brain’s circadian pacemaker, governs daily rhythms in behavior and physiology. Here we identified and characterized Gpr176 as an SCN-enriched orphan G-protein coupled receptor (GPCR) that sets the pace of the central clock（Doi et al, Nat Commun 2016）. Interestingly, even in the absence of known ligand, Gpr176 has an agonist-independent basal activity to reduce cAMP signaling. A unique cAMP-repressing G-protein subclass Gz is required for the activity of Gpr176. The discovery of the functional orphan GPCR with a novel mode of action within the SCN would be of help to understand the mechanism that underpins the SCN and thereby facilitate searching for a potential specific drug target to modulate the central clock.
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