Elucidation of the mechanisms that regulate stress response through protein phosphorylation signaling in mitochondria
Project/Area Number |
26293016
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Nagasaki University |
Principal Investigator |
TAKEDA Kohsuke 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (10313230)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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Keywords | ミトコンドリア / ストレス応答 / タンパク質リン酸化 / プロテインホスファターゼ |
Outline of Final Research Achievements |
The mitochondrial protein phosphatase, PGAM5, is regarded to be a molecule that senses mitochondrial dysfunction and regulates appropriate cellular response to it. In this study, we found the following results: 1) PGAM5 exerts its catalytic activity in a dodecamer, which consists of six dimers; 2) PGAM5 regulates lipid metabolism in response to some kind of metabolic stress; 3) a fraction of PGAM5 that is cleaved during apoptosis or mitophagy is translocated to the nucleus, where PGAM5 regulates alternative pre-mRNA splicing. These results demonstrate that PGAM5 is a novel regulator that functions in cellular response to mitochondrial stress.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3.2017
Author(s)
Honda, S., Sadatomi, D., Yamamura, Y., Nakashioya, K., Tanimura, S. and Takeda, K.
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Journal Title
Cancer Sci.
Volume: 108
Issue: 3
Pages: 520-527
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation.2017
Author(s)
Sadatomi, D., Nakashioya, K., Mamiya, S., Honda, S., Kameyama, Y., Yamamura, Y., Tanimura, S. and Takeda, K.
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Journal Title
J. Biochem.
Volume: 印刷中
Pages: 503-512
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips.2016
Author(s)
Tanimura, S., Hashizume, J., Arichika, N., Watanabe, K., Ohyama, K., Takeda, K. and Kohno, M.
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Journal Title
J. Cell Biol.
Volume: 214
Issue: 4
Pages: 475-489
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The ablation of mitochondrial protein phosphatase pgam5 confers resistance against metabolic stress2016
Author(s)
Sekine S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., Ichijo, H
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Journal Title
EBioMedicine
Volume: 6
Pages: 82-92
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.2015
Author(s)
Okazaki T., Higuchi M., Takeda K., Iwatsuki-Horimoto K., Kiso M., Miyagishi M., Yanai H., Kato A., Yoneyama M., Fujita T., Taniguchi T., Kawaoka Y., Ichijo H. and Gotoh Y.
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Journal Title
Science Signaling
Volume: 8
Issue: 388
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] ASK1 promotes the contact hypersensitivity response through IL-17 production2014
Author(s)
Mizukami, J. Sato, T., Camps, M., Ji, H., Rueckle, T., Swinnen, D., Tsuboi, R., Takeda, K. and Ichijo, H
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Journal Title
Sci. Rep.
Volume: 4
Issue: 1
Pages: 4714-4714
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The DEAH-Box RNA Helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses2014
Author(s)
Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I. and Ichijo, H.
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Journal Title
Sci. Signal.
Volume: 7
Issue: 323
DOI
Related Report
Peer Reviewed
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[Presentation] Extra-mitochondrial function of cleaved PGAM5.2016
Author(s)
Yamaguchi, A., Tokudome, R., Nima, C., Yokozeki, M., Ishikawa, I., Tanimura, S., Takeda, K.
Organizer
The 12th International Conference on Protein Phosphatase
Place of Presentation
近畿大学(大阪府東大阪市)
Year and Date
2016-10-28
Related Report
Int'l Joint Research
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