| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
The mitochondrial protein phosphatase, PGAM5, is regarded to be a molecule that senses mitochondrial dysfunction and regulates appropriate cellular response to it. In this study, we found the following results: 1) PGAM5 exerts its catalytic activity in a dodecamer, which consists of six dimers; 2) PGAM5 regulates lipid metabolism in response to some kind of metabolic stress; 3) a fraction of PGAM5 that is cleaved during apoptosis or mitophagy is translocated to the nucleus, where PGAM5 regulates alternative pre-mRNA splicing. These results demonstrate that PGAM5 is a novel regulator that functions in cellular response to mitochondrial stress.
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