The role of novel inflammatory helper T cells that are highly capable of producing IL-13 in allergic inflammatory diseases
| Project/Area Number |
26293017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
Iwata Makoto 徳島文理大学, 薬学部, 教授 (50160122)
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| Co-Investigator(Kenkyū-buntansha) |
宋 時栄 徳島文理大学, 大学共同利用機関等の部局等, 教授 (00399693)
門脇 則光 香川大学, 医学部, 教授 (60324620)
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| Co-Investigator(Renkei-kenkyūsha) |
OHOKA Yoshiharu 徳島文理大学, 香川薬学部, 准教授 (60303971)
TAKEUCHI Hajime 徳島文理大学, 香川薬学部, 准教授 (00421298)
NAKATSUMA Aya (YOKOTA Aya) 徳島文理大学, 香川薬学部, 助教 (30446075)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | アレルギー / 炎症 / レチノイン酸 / IL-13 / ヘルパーT細胞 |
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| Outline of Final Research Achievements |
In vitamin A-deficient mice, oral tolerance was not normally induced. Furthermore, very strong IgG1 and IgE antibody responses could be induced against oral antigens in an IL-13-dependet manner. On the other hand, the CD103(－)CD11b(+) subset of mesenteric lymph node dendritic cells in these mice induced differentiation of novel inflammatory helper T cells that are highly capable of producing IL-13 and TNF-α in an IL-6-dependent manner. These T cells are suggested to participate in the IL-13-dependent antibody responses to oral antigens, and preferentially migrated into inflamed skin. Retinoic acid receptor-mediated signaling suppressed the induction of these helper T cells. TGF-β also suppressed their induction, but reciprocally enhanced the induction of IL-17A-producing T cells.
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Report
(4 results)
Research Products
(27 results)
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[Presentation] The role of retinoic acid in immune functions2015
Author(s)
Makoto Iwata
Organizer
Academy of Immunology and Microbiology (AIM), The Institute for Basic Science (IBS) in Pohang University of Science and Technology (POSTECH), Korea
Place of Presentation
The Institute for Basic Science (IBS) in Pohang University of Science and Technology (POSTECH), Pohang, Korea
Year and Date
2015-05-27
Related Report
Int'l Joint Research / Invited
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