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Study on the molecular mechanism of psychiatric disorders that targets PACAP signaling pathways and aimed at the development of therapeutic drug

Research Project

Project/Area Number 26293020
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pharmacology in pharmacy
Research InstitutionOsaka University

Principal Investigator

Hashimoto Hitoshi  大阪大学, 薬学研究科, 教授 (30240849)

Co-Investigator(Kenkyū-buntansha) 早田 敦子  大阪大学, 連合小児発達学研究科, 助教 (70390812)
Co-Investigator(Renkei-kenkyūsha) HASHIMOTO Ryota  大阪大学, 大学院連合小児発達学研究科, 准教授 (10370983)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
KeywordsPACAP / 精神疾患 / 創薬 / 薬学 / 国際情報交換
Outline of Final Research Achievements

Pathophysiological mechanisms for psychiatric disorders remain poorly understood, which need to be urgently addressed. Recent studies have suggested that PACAP is implicated in neuropsychological functions and the risk and pathogenesis of psychiatric disorders. In this study, in order to obtain insights relevant to drug development, we examined brain signaling pathways as well as intracellular signaling pathways that are relevant to PACAP-dependent signaling. We obtained the data showing that the implication of noradrenaline in PACAP-deficient mouse phenotypes, involvement of BDNF signaling in PACAP-dependent axon outgrowth, necessity of β-arrestin2 for PACAP-induced 5-HT2A receptor internalization, and interaction and internalization of PACAP receptor PAC1 with β-arrestin2, which induces prolonged ERK1/2 activation. The present observations as well as the assay systems generated are expected to contribute to future drug discovery research.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (126 results)

All 2018 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (49 results) (of which Int'l Joint Research: 16 results,  Peer Reviewed: 49 results,  Open Access: 26 results,  Acknowledgement Compliant: 15 results) Presentation (73 results) (of which Int'l Joint Research: 13 results,  Invited: 5 results) Remarks (2 results)

  • [Int'l Joint Research] カリフォルニア大学ロサンゼルス校(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] カリフォルニア大学ロサンゼルス校(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Targeted knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism2018

    • Author(s)
      Inoue N, Ogura S, Kasai A, Nakazawa T, Ikeda K, Higashi S, Isotani A, Baba K, Mochizuki H, Fujimura H, Ago Y, Hayata-Takano A, Seiriki K, Shintani N, Hashimoto H
    • Journal Title

      EMBO Reports

      Volume: 19(3) Issue: 3

    • DOI

      10.15252/embr.201744860

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unbiased compound screening with a reporter gene assay highlights the role of p13 in the cardiac cellular stress response2018

    • Author(s)
      Inoue N, Hirouchi T, Kasai A, Higashi S, Hiraki N, Tanaka S, Nakazawa T, Nunomura K, Lin B, Omori A, Hayata-Takano A, Kim YJ, Doi T, Baba A, Hashimoto H, Shintani N
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 495(2) Issue: 2 Pages: 1992-1997

    • DOI

      10.1016/j.bbrc.2017.11.116

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disturbed spermatogenic signaling in pituitary adenylate cyclase activating polypeptide-deficient mice2018

    • Author(s)
      Reglodi D, Cseh S, Somoskoi B, Fulop BD, Szentleleky E, Szegeczki V, Kovacs A, Varga A, Kiss P, Hashimoto H, Tamas A, Bardosi A, Manavalan S, Bako E, Zakany R, Juhasz T
    • Journal Title

      Reproduction

      Volume: 155(2) Issue: 2 Pages: 129-139

    • DOI

      10.1530/rep-17-0470

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Construct and face validity of a new model for the three-hit theory of depression using PACAP mutant mice on CD1 background2018

    • Author(s)
      Farkas J, Kovacs LA, Gaspar L, Nafz A, Gaszner T, Ujvari B, Kormos V, Csernus V, Hashimoto H, Reglodi D, Gaszner B
    • Journal Title

      Neuroscience

      Volume: 354 Pages: 11-29

    • DOI

      10.1016/j.neuroscience.2017.04.019

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impaired extinction of cued fear memory and abnormal dendritic morphology of the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice2017

    • Author(s)
      Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Takeuchi S, Cushman JD, Rajbhandari AK, Fanselow MS, Hashimoto H, Waschek JA
    • Journal Title

      Neurobiology of Learning and Memory

      Volume: 145 Pages: 222-231

    • DOI

      10.1016/j.nlm.2017.10.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice2017

    • Author(s)
      Ivic I, Solymar M, Fulop BD, Hashimoto H, Toth G, Tamas A, Juhasz T, Koller A, Reglodi D
    • Journal Title

      J. Vasc. Res.

      Volume: 54(6) Issue: 6 Pages: 359-366

    • DOI

      10.1159/000481781

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice2017

    • Author(s)
      Hara Y, Ago Y, Taruta A, Hasebe S, Kawase H, Tanabe W, Tsukada S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 234(21) Issue: 21 Pages: 3217-3228

    • DOI

      10.1007/s00213-017-4703-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocin attenuates deficits in social interaction but not recognition memory in a prenatal valproic acid-induced mouse model of autism2017

    • Author(s)
      Hara Y, Ago Y, Higuchi M, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K
    • Journal Title

      Hormones and Behavior

      Volume: 96 Pages: 130-136

    • DOI

      10.1016/j.yhbeh.2017.09.013

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-speed and scalable whole-brain imaging in rodents and primates2017

    • Author(s)
      Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H
    • Journal Title

      Neuron

      Volume: 94 Issue: 6 Pages: 1085-1100

    • DOI

      10.1016/j.neuron.2017.05.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Psychopharmacology of combined activation of the serotonin1A and σ1 receptors2017

    • Author(s)
      Ago Y, Hasebe S, Hiramatsu N, Hashimoto H, Takuma K, Matsuda T
    • Journal Title

      European Journal of Pharmacology

      Volume: 809 Pages: 172-177

    • DOI

      10.1016/j.ejphar.2017.05.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Environmental enrichment attenuates behavioral abnormalities in valproic acid-exposed autism model mice2017

    • Author(s)
      Yamaguchi H, Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K
    • Journal Title

      Behav. Brain Res.

      Volume: 333 Pages: 67-73

    • DOI

      10.1016/j.bbr.2017.06.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain.2017

    • Author(s)
      Hara Y, Ago Y, Takano E, Hasebe S, Nakazawa T, Hashimoto H, Matsuda T, Takuma K.
    • Journal Title

      Molecular Autism

      Volume: 8 Issue: 1 Pages: 33-33

    • DOI

      10.1186/s13229-017-0149-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Backup mechanisms maintain PACAP/VIP-induced arterial relaxations in pituitary adenylate cyclase-activating polypeptide-deficient mice2017

    • Author(s)
      Ivic I, Fulop BD, Juhasz T, Reglodi D, Toth G, Hashimoto H, Tamas A, Koller A
    • Journal Title

      J. Vasc. Res.

      Volume: 54 Issue: 3 Pages: 180-192

    • DOI

      10.1159/000457798

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Decreased cohesion in the brain leads to defective synapse development and anxiety-related behavior2017

    • Author(s)
      Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T.
    • Journal Title

      J. Exp. Med.

      Volume: 印刷中 Issue: 5 Pages: 1431-1452

    • DOI

      10.1084/jem.20161517

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Clozapine on DNA Methylation in Peripheral Leukocytes from Patients with Treatment-Resistant Schizophrenia.2017

    • Author(s)
      Kinoshita M, Numata S, Tajima A, Yamamori H, Yasuda Y, Fujimoto M, Watanabe S, Umehara H, Shimodera S, Nakazawa T, Kikuchi M, Nakaya A, Hashimoto H, Imoto I, Hashimoto R, Ohmori T.
    • Journal Title

      Int J Mol Sci.

      Volume: 18 Issue: 3 Pages: 632-632

    • DOI

      10.3390/ijms18030632

    • NAID

      120006535029

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine.2017

    • Author(s)
      Nakazawa T, Kikuchi M, Ishikawa M, Yamamori H, Nagayasu K, Matsumoto T, Fujimoto M, Yasuda Y, Fujiwara M, Okada S, Matsumura K, Kasai A, Hayata-Takano A, Shintani N, Numata S, Takuma K, Akamatsu W, Okano H, Nakaya A, Hashimoto H, Hashimoto R.
    • Journal Title

      Schizophr Res.

      Volume: 181 Pages: 75-82

    • DOI

      10.1016/j.schres.2016.10.012

    • NAID

      120007037467

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Implantable optogenetic device with CMOS IC technology for simultaneous optical measurement and stimulation2017

    • Author(s)
      Makito Haruta,Naoya Kamiyama,Shun Nakajima,Mayumi Motoyama,Mamiko Kawahara Yasumi Ohta,Atsushi Yamasaki,Hiroaki Takehara,Toshihiko Noda,Kiyotaka Sasagawa,Yasuyuki Ishikawa,Takashi Tokuda,Hitoshi Hashimoto,Jun Ohta
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 5 Pages: 057001-057001

    • DOI

      10.7567/jjap.56.057001

    • NAID

      210000147741

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Early Neurobehavioral Development of Mice Lacking Endogenous PACAP2017

    • Author(s)
      Farkas J, Sandor B, Tamas A, Kiss P, Hashimoto H, Nagy AD, Fulop BD, Juhasz T, Manavalan S, Reglodi D.
    • Journal Title

      J. Mol. Neurosci.

      Volume: 61(4) Issue: 4 Pages: 468-478

    • DOI

      10.1007/s12031-017-0887-z

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Anti-anhedonic effect of selective serotonin reuptake inhibitors with affinity for sigma-1 receptors in picrotoxin-treated mice2017

    • Author(s)
      Hasebe S, Ago Y, Watabe Y, Oka S, Hiramatsu N, Tanaka T, Umehara C, Hashimoto H, Takuma K, Matsuda T
    • Journal Title

      British Journal of Pharmacology

      Volume: 174 Issue: 4 Pages: 314-327

    • DOI

      10.1111/bph.13692

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice2016

    • Author(s)
      Tanaka T, Ago Y, Umehara C, Imoto E, Hasebe S, Hashimoto H, Takuma K, Matsuda T.
    • Journal Title

      Int. J. Neuropsychopharmacol.

      Volume: 20 Pages: 410-420

    • DOI

      10.1093/ijnp/pyw115

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Critical involvement of the orbitofrontal cortex in hyperlocomotion induced by NMDA receptor blockade in mice.2016

    • Author(s)
      Seiriki K, Kasai A, Kuwaki T, Nakazawa T, Yamaguchi S, Hashimoto H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 480 Issue: 4 Pages: 558-563

    • DOI

      10.1016/j.bbrc.2016.10.089

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Double In situ Hybridization for MicroRNAs and mRNAs in Brain Tissues.2016

    • Author(s)
      Kasai A, Kakihara S, Miura H, Okada R, Hayata-Takano A, Hazama K, Niu M, Shintani N, Nakazawa T, Hashimoto H.
    • Journal Title

      Front Mol Neurosci.

      Volume: 9 Pages: 126-126

    • DOI

      10.3389/fnmol.2016.00126

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks2016

    • Author(s)
      Lacaille H, Duterte-Boucher D, Vaudry H, Zerdoumi Y, Flaman JM, Hashimoto H, Vaudry D.
    • Journal Title

      Mol. Neurobiol.

      Volume: 印刷中 Issue: 9 Pages: 7534-7548

    • DOI

      10.1007/s12035-016-0204-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation2016

    • Author(s)
      Kawanai T, Ago Y, Watanabe R, Inoue A, Taruta A, Onaka Y, Hasebe S, Hashimoto H, Matsuda T, Takuma K.
    • Journal Title

      Neurochem. Res.

      Volume: 41(10) Issue: 10 Pages: 2574-2584

    • DOI

      10.1007/s11064-016-1969-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism2016

    • Author(s)
      Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K
    • Journal Title

      Autism Research

      Volume: - Issue: 9 Pages: 926-939

    • DOI

      10.1002/aur.1596

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency2016

    • Author(s)
      Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
    • Journal Title

      Psychopharmacology(Berl)

      Volume: 233(17) Issue: 17 Pages: 3125-3134

    • DOI

      10.1007/s00213-016-4353-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers2016

    • Author(s)
      Kormos V, Gaspar L, Kovacs, Farkas J, Gaszner T, Csernus V, Balogh A, Hashimoto H, Reglodi D, Helyes Z, Gaszner B.
    • Journal Title

      Neuroscience

      Volume: 330 Pages: 335-358

    • DOI

      10.1016/j.neuroscience.2016.06.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] PACAP suppresses dry eye signs by stimulating tear secretion2016

    • Author(s)
      Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
    • Journal Title

      Nat. Commun.

      Volume: 7 Issue: 1 Pages: 12034-12034

    • DOI

      10.1038/ncomms12034

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ2016

    • Author(s)
      Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
    • Journal Title

      J. Mol. Psychiatry

      Volume: 4 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s40303-016-0016-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is involved in adult mouse hippocampal neurogenesis after stroke2016

    • Author(s)
      Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S.
    • Journal Title

      J Mol Neurosci.

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor.2016

    • Author(s)
      Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 22373-22373

    • DOI

      10.1038/srep22373

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Erratum: class FormattedString { value: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders (Nature Communications (2016) 7 (10594) DOI: 10.1038/ncomms10594) }2016

    • Author(s)
      Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M.
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 10594-10594

    • DOI

      10.1038/ncomms11466

    • URL

      https://pure.teikyo.jp/en/publications/02dbd5f8-68c0-49be-bd3c-a3b8c759f202

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rivastigmine improves isolation rearing-induced prepulse inhibition deficits via muscarinic acetylcholine receptors in mice2016

    • Author(s)
      Higashino K, Ago Y, Umeki T, Hasebe S, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
    • Journal Title

      Psychopharmacology (Berl).

      Volume: 233(3) Issue: 3 Pages: 521-528

    • DOI

      10.1007/s00213-015-4123-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder.2015

    • Author(s)
      Hashimoto R, Nakazawa T, Tsurusaki Y, Yasuda Y, Nagayasu K, Matsumura K, Kawashima H, Yamamori H, Fujimoto M, Ohi K, Umeda-Yano S, Fukunaga M, Fujino H, Kasai A, Hayata-Takano A, Shintani N, Takeda M, Matsumoto N, Hashimoto H.
    • Journal Title

      Journal of Human Genetics

      Volume: 61 Issue: 3 Pages: 199-206

    • DOI

      10.1038/jhg.2015.141

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structured line illumination Raman microscopy2015

    • Author(s)
      Watanabe K, Palonpon AF, Smith NI, Chiu LD, Kasai A, Hashimoto H, Kawata S, Fujita K.
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 10095-10095

    • DOI

      10.1038/ncomms10095

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The female encounter test, a novel method for evaluating reward-seeking behavior or motivation in mice2015

    • Author(s)
      Ago Y, Hasebe S, Nishiyama S, Oka S, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
    • Journal Title

      Neuropsychopharmacol.

      Volume: 18(11) Issue: 11 Pages: pyv062-pyv062

    • DOI

      10.1093/ijnp/pyv062

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice2015

    • Author(s)
      Hasebe S, Ago Y, Nishiyama S, Oka S, Hashimoto H, Takuma K, Matsuda T.
    • Journal Title

      Behav Pharmacol.

      Volume: 26(7) Issue: 7 Pages: 681-690

    • DOI

      10.1097/fbp.0000000000000140

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist2015

    • Author(s)
      Ago Y, Condro MC, Tan YV, Ghiani CA, Colwell CS, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.
    • Journal Title

      Psychopharmacology (Berl).

      Volume: 232(12) Issue: 12 Pages: 2181-2189

    • DOI

      10.1007/s00213-014-3848-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Atomoxetine reverses locomotor hyperactivity, impaired novel object recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).2015

    • Author(s)
      hibasaki Y, Hayata-Takano A, Hazama K, Nakazawa T, Shintani N, Kasai A, Nagayasu K, Hashimoto R, Tanida M, Katayama T, Matsuzaki S, Yamada K, Taniike M, Onaka Y, Ago Y, Waschek JA, Köves K, Reglődi D, Tamas A, Matsuda T, Baba A, Hashimoto H.
    • Journal Title

      Neuroscience

      Volume: 297 Pages: 95-104

    • DOI

      10.1016/j.neuroscience.2015.03.062

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model2015

    • Author(s)
      Hara Y, Takuma K, Takano E, Katashiba K, Taruta A, Higashino K, Hashimoto H, Ago Y, Matsuda T.
    • Journal Title

      Behav Brain Res.

      Volume: 289 Pages: 39-47

    • DOI

      10.1016/j.bbr.2015.04.022

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice2015

    • Author(s)
      Yusuke Onaka, Norihito Shintani, Takanobu Nakazawa, Ryota Haba, Yukio Ago, Hyper Wang, Takuya Kanoh, Atsuko Hayata-Takano, Hiroyuki Hirai, Kin-ya Nagata, Masataka Nakamura, Ryota Hashimoto, Toshio Matsuda, James A. Waschek, Atsushi Kasai, Kazuki Nagayasu, Akemichi Baba, Hitoshi Hashimoto
    • Journal Title

      Behavioural Brain Research

      Volume: 284 Pages: 131-137

    • DOI

      10.1016/j.bbr.2015.02.013

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anxiolytic-like effects of restraint during the dark cycle in adolescent mice2015

    • Author(s)
      Ota Y, Ago Y, Tanaka T, Hasebe S, Toratani Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T
    • Journal Title

      Behavioural Brain Research

      Volume: 284 Pages: 103-111

    • DOI

      10.1016/j.bbr.2015.02.010

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells.2015

    • Author(s)
      Malchenko S, Sredni ST, Hashimoto H, Kasai A, Nagayasu K, Xie J, Margaryan NV, Seiriki K, Lulla RR, Seftor RE, Pachman LM, Meltzer HY, Hendrix MJ, Soares MB.
    • Journal Title

      PLoS One

      Volume: 10(3)

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] PACAP Enhances Axon Outgrowth in Cultured Hippocampal Neurons to a Comparable Extent as BDNF.2015

    • Author(s)
      Ogata K, Shintani N, Hayata-takano A, Kamo T, Higashi S, Seiriki K, Momosaki H, Vaudy D, Vaudy H, Galas L, Kasai A, Nagayasu K, Nakazawa T, Hashimoto R, Ago Y, Matsuda T, Baba A, Hashimoto H.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: e0120526-e0120526

    • DOI

      10.1371/journal.pone.0120526

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous neuron- and astrocyte-specific fluorescent marking.2015

    • Author(s)
      Schulze W, Hayata-Takano A, Kamo T, Nakazawa T, Nagayasu K, Kasai A, Seiriki K, Shintani N, Ago Y, Farfan C, Hashimoto R, Baba A, Hashimoto H.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 459 Issue: 1 Pages: 81-86

    • DOI

      10.1016/j.bbrc.2015.02.073

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of the role of BMP and TGF-β signaling in the trajectory of serotonergic differentiation in a rapid assay in mouse embryonic stem cells in vitro.2015

    • Author(s)
      Yamasaki A, Kasai A, Toi A, Kurita M, Kimoto S, Hayata-Takano A, Nakazawa T, Nagayasu K, Shintani N, Hashimoto R, Ito A, Meltzer HY, Ago Y, Waschek JA, Onaka Y, matsuda T, Baba A, Hashimoto H.
    • Journal Title

      Journal of Neurochemistry,

      Volume: 132(4) Issue: 4 Pages: 418-428

    • DOI

      10.1111/jnc.12999

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of the 5-HT1A Autoreceptor in the Enhancement of Fluvoxamine-Induced Increases in Prefrontal Dopamine Release by Adrenalectomy/Castration in Mice.2014

    • Author(s)
      Hasebe S, Hiramatsu N, Ago Y, Mori K, Watabe Y, Hashimoto H, Takuma K, Matsuda T
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 127 Issue: 2 Pages: 232-235

    • DOI

      10.1016/j.jphs.2015.01.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral characterization of mice overexpressing human dysbindin-1.2014

    • Author(s)
      Shintani N, Onaka Y, Hashimoto R, Takamura H, Nagata T, Umeda-Yano S, Mouri A, Mamiya T, Haba R, Matsuzaki S, Katayama T, Yamamori H, Nakazawa T, Nagayasu K, Ago Y, Yagasaki Y, Nabeshima T, Takeda M, Hashimoto H.
    • Journal Title

      Mol Brain.

      Volume: 7(1) Pages: 74-74

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Structural and morphometric comparison of the molar teeth in pre-eruptive developmental stage of PACAP-deficient and wild-type mice.2014

    • Author(s)
      Sandor B, Fintor K, Felszeghy S, Juhasz T, Reglodi D, Mark L, Kiss P, Jungling A, Fulop BD, Nagy AD, Hashimoto H, Zakany R, Nagy A, Tamas A.
    • Journal Title

      J Mol Neurosci.

      Volume: 54(3) Issue: 3 Pages: 331-341

    • DOI

      10.1007/s12031-014-0392-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] High-speed whole brain imaging with subcellular resolution and comparison analysis2017

    • Author(s)
      笠井淳司、橋本均
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 精神的ストレスにより活性化する神経核の情動行動における役割2017

    • Author(s)
      丹生光咲、笠井淳司、勢力薫、五十嵐久人、山口瞬、山中章弘、中澤敬信、橋本均
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 全脳活動マッピングを用いたNMDA受容体拮抗薬誘発行動異常にかかわる脳部位の解析2017

    • Author(s)
      勢力薫、笠井淳司、桑木崇宏、丹生光咲、中雄一郎、五十嵐久人、中澤敬信、山口瞬、吾郷由希夫、橋本均
    • Organizer
      第90回薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] CNS創薬を支援する疾患モデルの開発2017

    • Author(s)
      橋本均、笠井淳司、中澤敬信
    • Organizer
      日本安全性薬理研究会第8回学術年会
    • Place of Presentation
      東京
    • Year and Date
      2017-02-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Modeling VIPR2 linkages to schizophrenia in mice2017

    • Author(s)
      Ago Y, Hayata-Takano A, Rajbhandari A, Fanselow M, Hashimoto H, Waschek JA
    • Organizer
      The 13th International Symposium on VIP, PACAP and Related Peptides
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Astrocyte-neuron lactate shuttle playes pivotal role in PACAP mediated fear memory acquisition or retrieval in mice2017

    • Author(s)
      Nakashima Y, Kambe Y, Trung NT, Shintani N, Hashimoto H, Miyata A
    • Organizer
      The 13th International Symposium on VIP, PACAP and Related Peptides
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparative effects of ketamine isomers, R-ketamine and S-ketamine, in mouse models of depression2017

    • Author(s)
      Ago Y, Higuchi M, Tanabe W, Seiriki K, Igarashi H, Hashimoto K, Hashimoto H
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Saturated Excitation Microscopy Using Image Subtraction2017

    • Author(s)
      Nawa Y, Yonemaru Y, Kasai A, Smith NI, Hashimoto H, Kawata S, Fujita K
    • Organizer
      ICO24 (The 24th Congress of the International Commission for Optics)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Whole-brain mapping analysis of the NMDAR antagonist-induced neuronal activity2017

    • Author(s)
      Seiriki K, Kasai A, Kuwaki T, Niu M, Naka Y, Igarashi H, Nakazawa T, Yamaguchi S, Ago Y, Hashimoto H
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高頻度にde novo変異が認められる自閉スペクトラム症関連遺伝子POGZの患者由来iPS細胞を用いた分子病態解析2017

    • Author(s)
      岡田翔太,松村憲佑,中澤敬信,永安一樹,馬場優志,笠井淳司,吾郷由希夫,田熊一敞,山森英長,安田由華,橋本亮太,橋本均
    • Organizer
      第132回 日本薬理学会 近畿部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自閉スペクトラム症モデルマウスの社会性行動障害に有効な抗てんかん作用を有する医薬品の探索2017

    • Author(s)
      三浦大樹,笠井淳司,彌永祐輔,原雄大,中澤敬信,吾郷由希夫,田熊一敞, 橋本均
    • Organizer
      第132回 日本薬理学会 近畿部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒトiPS細胞からセロトニン神経細胞への分化誘導法の開発2017

    • Author(s)
      桝中このみ,永安一樹,中澤敬信,吾郷由希夫,田熊一敞, 橋本均
    • Organizer
      第132回 日本薬理学会 近畿部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Endogenous PACAP increases food intake by modulating the neuropeptides expression in the hypothalamus2017

    • Author(s)
      Trung NT, Kambe Y, Kurihara T, Shintani N, Hashimoto H, Miyata A
    • Organizer
      第70回日本薬理学会西南部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自閉スペクトラム症に高頻度に認めるPOGZ遺伝子座の患者特異的de novo変異の表現型解析2017

    • Author(s)
      中澤敬信,田熊一敞, 橋本亮太,橋本均
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ブチリルコリンエステラーゼ阻害によるグレリンシグナルの活性化を介した中枢ムスカリンM1受容体機能の亢進2017

    • Author(s)
      吾郷由希夫, 東野功典, 国本寿美子, 塚田信司, Nigel H. Greig, 松田敏夫, 橋本均
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 全脳マッピングと神経活動操作による情動行動制御機構の解明2017

    • Author(s)
      笠井淳司, 丹生光咲, 勢力薫, 五十嵐久人, 桑木崇宏, 田沼将人, 中澤敬信, 山口瞬, 山中章宏, 橋本均
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 全脳イメージング法を用いた精神疾患モデルマウスの機能評価2017

    • Author(s)
      橋本均
    • Organizer
      第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 精神疾患の病態解析と創薬へ向けたモデル研究2017

    • Author(s)
      橋本均
    • Organizer
      第61回薬学会関東支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 複数の自閉症患者にde novo変異が認められるPRKD2遺伝子産物の機能解析2017

    • Author(s)
      馬場優志,松村憲佑,中澤敬信,永安一樹,笠井淳司,田熊一敞, 橋本均
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自閉スペクトラム症に高頻度に変異が認められる遺伝子POGZは神経細胞の分化制御に関与する2017

    • Author(s)
      松村憲佑,中澤敬信,永安一樹,三浦大樹,笠井淳司,田熊一敞,山森英長,安田由華,橋本亮太,橋本均
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] β-アレスチンを介する PACAP-PAC1 シグナルの解析2017

    • Author(s)
      新谷勇介,早田敦子, 橋本均
    • Organizer
      第131回 日本薬理学会 近畿部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] VPAC2受容体を介する大脳皮質神経神経発達異常と精神疾患との関連2017

    • Author(s)
      吾郷由希夫、早田敦子、河内琢也、山内良介、James Waschek、橋本均
    • Organizer
      第90回薬理学会年会
    • Place of Presentation
      長崎
    • Related Report
      2016 Annual Research Report
  • [Presentation] ASD-associated de novo mutations in POGZ impair the DNA-binding activity of POGZ2016

    • Author(s)
      Nakazawa T, Matsumura K, Nagayasu K, Kasai A, Hayata-Takano A, Shintani N, Takuma K, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H.
    • Organizer
      55th Annual Meeting, ACNP
    • Place of Presentation
      アメリカ
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of the VPAC2 receptor inhibits neurite outgrowth and branching of cortical neurons by a PKA-dependent mechanism2016

    • Author(s)
      Hashimoto H, Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Waschek JA.
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      アメリカ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 全脳イメージングによる脳機能・疾患機序の解析2016

    • Author(s)
      橋本均、勢力薫、丹生光咲、中雄一郎、笠井淳司
    • Organizer
      第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 神経細胞の成熟におけるPACAPとBDNFの役割2016

    • Author(s)
      早田 敦子、加茂 俊彦、勢力 薫、尾形 勝弥、中澤 敬信、吾郷 由希夫、永安 一樹、笠井 淳司、新谷 紀人、橋本 均
    • Organizer
      第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] ドパミン神経賦活薬の慢性投与は胎仔期バルプロ酸曝露マウスの自閉症様行動を改善する2016

    • Author(s)
      長谷部茂、原雄大、樋口桃子、吾郷由希夫、中澤敬信、橋本均、松田敏夫、田熊一敞
    • Organizer
      第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Overactivation of the VPAC2 receptor during the early postnatal period causes prefrontal synaptic abnormalities and cognitive dysfundtion in mice2016

    • Author(s)
      Ago Y, Hayata A, Kawanai T, Yamauchi R, Waschek JA, Hashimoto H.
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      韓国
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iPS細胞技術を用いた統合失調症患者のクロザピン応答性の個人間の相違の分子機構解析2016

    • Author(s)
      中澤敬信、橋本亮太、橋本均
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      韓国
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] 精神的ストレスによる覚せい剤精神病の再燃現象におけるセロトニン受容体の関与2016

    • Author(s)
      田中辰典、吾郷由希夫、梅原千晶、長谷部 茂、橋本 均、田熊一敞、松田敏夫
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 統合失調症におけるVIP/PACAP受容体VPAC2活性化の病態的意義2016

    • Author(s)
      吾郷由希夫、河内琢也、山内良介、早田敦子、James Waschek、橋本 均
    • Organizer
      第13回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 発育期の環境要因が精神・神経機能に及ぼす影響2016

    • Author(s)
      田熊一敞, 吾郷由希夫, 長谷部 茂, 橋本均, 松田敏夫
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 雌性マウスを用いた意欲・報酬探索行動評価試験2016

    • Author(s)
      川瀬啓生、吾郷由希夫、長谷部茂、岡智史、田熊一敞, 松田敏夫、橋本均
    • Organizer
      第129回日本薬理学会近畿部会
    • Place of Presentation
      広島
    • Related Report
      2016 Annual Research Report
  • [Presentation] 精神疾患の分子機構の解析と創薬に向けた疾患モデル研究2016

    • Author(s)
      橋本均
    • Organizer
      第61回脳の医学・生物学研究会
    • Place of Presentation
      名古屋
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Whole Brain Imaging to Investigate Physiology and Pathophysiology of Brain Disorders2016

    • Author(s)
      Hashimoto H.
    • Organizer
      VIMM Seminar (日伊国交150周年事業)
    • Place of Presentation
      イタリア
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 自閉スペクトラム症関連遺伝子POGZの患者特異的de novo変異の表現型解析2016

    • Author(s)
      松村憲佑、中澤敬信、永安一樹、三浦大樹、笠井淳司、田熊一敞、山森英長、安田由華、橋本亮太、橋本均
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2016
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report
  • [Presentation] 社会的敗北ストレスによる社会的忌避行動時の全脳神経活動マッピング2016

    • Author(s)
      五十嵐久人、笠井淳司、勢力薫、丹生光咲、中雄一郎、山浦港生、中澤敬信、橋本均
    • Organizer
      第130回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん治療後に認められる高次脳機能障害におけるシクロオキシゲナーゼの関与2016

    • Author(s)
      尾中勇祐、新谷紀人、 中澤敬信、吾郷由希夫、木野村 元彦、田邊 航、荻田 喜代一、橋本 均
    • Organizer
      第130回日本薬理学会近畿部会
    • Place of Presentation
      京都
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳病態を解明するモデル動物の全脳イメージング2015

    • Author(s)
      橋本均, 笠井淳司, 勢力薫, 丹生光咲, 中澤敬信
    • Organizer
      第6回脳表現型の分子メカニズム研究会
    • Place of Presentation
      コンベンションルームAP品川アネックスIルーム(東京・品川区)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] A new block-face serial microscopy tomography for computational mapping of brain cells, and unbiased comparative analysis2015

    • Author(s)
      Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Nakazawa T, Hashimoto H.
    • Organizer
      45th Society for Neuroscience Annual meeting (Neuroscience2015)
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Practical optimization of in situ hybridization procedure for the detection of microRNAs and mRNA expression in brain tissues2015

    • Author(s)
      Kasai A, Kakihara S, Okada R, Hazama K, Nakazawa T, Nagayasu K, Hayata-Takano A, Shintani N, Hashimoto H.
    • Organizer
      45th Society for Neuroscience Annual meeting (Neuroscience2015)
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Overactivation of the VPAC2 receptor during postnatal brain development causes prefrontal synaptic abnormalities and cognitive dysfunction in mice2015

    • Author(s)
      Ago Y, Condro MC, Tan YV, Hayata A, Kawanai T, Cushman JD, Fanselow MS, Hashimoto H, Waschek JA.
    • Organizer
      12th International Symposium on VIP/PACAP and Related Peptides
    • Place of Presentation
      カッパドキア(トルコ)
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of PACAP in Depressopm-Like Behavior2015

    • Author(s)
      Hashimoto H, Shintani N, Ago Y, Hayata-Takano A, Waschek JA, Baba A.
    • Organizer
      12th International Symposium on VIP/PACAP and Related Peptides
    • Place of Presentation
      カッパドキア(トルコ)
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ストレスにより活性化する神経細胞の全脳マッピングと定量的解析2015

    • Author(s)
      丹生光咲, 笠井淳司, 勢力薫, 山口瞬, 橋本岳, 中澤敬信, 橋本均
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2015
    • Place of Presentation
      東京大学薬学部(東京・文京区)
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 構造および神経活動の変化を定量的に検出する高精細三次元全脳形態計測システム2015

    • Author(s)
      勢力薫, 笠井淳司, 丹生光咲, 山口瞬, 橋本岳, 中澤敬信, 橋本均
    • Organizer
      第38回日本神経科学会大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自閉症の疾患特異的候補遺伝子の機能的スクリーニング2015

    • Author(s)
      松村憲佑, 橋本亮太, 中澤敬信, 鶴崎美徳, 安田由華, 永安一樹, 川島和, 山森英長, 藤本美智子, 大井一高, 梅田知美, 福永雅喜, 藤野陽生, 笠井淳司, 早田敦子, 新谷紀人, 武田雅俊, 松本直通, 橋本均
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 雌選択性試験:マウス間相互作用を基盤とした新規うつ様行動評価系2015

    • Author(s)
      長谷部茂, 岡智史, 尾中勇祐, 橋本均, 松田敏夫, 吾郷由希夫, 田熊一敞
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス活動期における拘束ストレスは抗不安様作用を示す2015

    • Author(s)
      田中辰典, 太田友樹, 大住康晃, 長谷部茂, 尾中勇祐, 橋本均, 松田敏夫, 田熊一敞, 吾郷由希夫
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] リバスチグミンのムスカリン受容体を介したプレパルスインヒビション障害改善作用2015

    • Author(s)
      東野功典, 梅木孝弘, 尾中勇祐, 橋本均, 松田敏夫, 田熊一敞, 吾郷由希夫
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫・神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] がん治療後の脳機能障害の解明に有用な動物モデルの作製2015

    • Author(s)
      尾中勇祐, 木野村元彦, 新谷紀人, 平井博之, 永田欽也, 中村正孝, 長谷部茂, 永安一樹, 吾郷由希夫, 笠井淳司, 早田敦子, 中澤敬信, 田熊一敞, 松田敏夫, 馬場明道, 橋本均
    • Organizer
      第127回日本薬理学会近畿部会
    • Place of Presentation
      長良川国際会議場(岐阜・岐阜市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性的な社会的敗北ストレスによる内側前頭前皮質におけるPACAP発現低下とエピジェネティクス関連因子の発現変化2015

    • Author(s)
      川瀬啓生、笠井淳司、小川純明、狭間啓佑、早田敦子、新谷紀人、馬場明道、橋本均
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸 神戸学院大学
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高精細三次元定量的全脳解析システムの構築と脳内変化の検出2015

    • Author(s)
      笠井淳司、勢力薫、丹生光咲、橋本岳、橋本均
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸 神戸学院大学
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高精細全脳形態計測システムの構築2015

    • Author(s)
      勢力薫、笠井淳司、丹生光咲、山口瞬、橋本岳、橋本均
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋 名古屋国際会議場
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノム科学による霊長類脳の多様性の解明2015

    • Author(s)
      橋本亮太、中澤敬信、今井啓雄、井上謙一、安田由華、山森英長、大井一高、 松村憲佑、 永安一樹、三浦健一郎、福永雅喜、高田 昌彦、武田雅俊、 橋本 均
    • Organizer
      平成26年度 京都大学霊長類研究所共同利用研究会「霊長類脳科学の新しい展開とゲノム科学との融合」
    • Place of Presentation
      京都 京都大学霊長類研究所
    • Year and Date
      2015-03-13 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mitophagy and inhibition of mitochondrial fusion.2015

    • Author(s)
      Shintani N, Hashimoto H, Scorrano L.
    • Organizer
      13 th Annual Retreat
    • Place of Presentation
      Venetian Institute of Molecular Medicine
    • Year and Date
      2015-02-06 – 2015-02-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] International collaborative research focusing on the oxidative stress hypothesis for novel drug development in psychiatric diseases.2015

    • Author(s)
      橋本均
    • Organizer
      都医学研セミナー
    • Place of Presentation
      東京 東京都医学総合研究所
    • Year and Date
      2015-01-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高精細三次元定量的全脳解析法の構築:マイクロエンドフェのタイプの探索へ2014

    • Author(s)
      笠井淳司、勢力薫、丹生光咲、橋本岳、橋本均
    • Organizer
      2014年度包括脳ネットワーク冬のシンポジウム
    • Place of Presentation
      東京 東京医科歯科大学 湯島キャンパス
    • Year and Date
      2014-12-12 – 2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 自閉スペクトラム症関連候補遺伝子のハイスループット機能評価系による解析2014

    • Author(s)
      永安一樹、松村憲佑、中澤敬信、安田由華、山森英長、梅田知美、大井一高、橋本亮太、武田雅俊、橋本均
    • Organizer
      2014年度包括脳ネットワーク冬のシンポジウム
    • Place of Presentation
      東京 東京医科歯科大学 湯島キャンパス
    • Year and Date
      2014-12-12 – 2014-12-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Brain-enriched Sorting Nexin Family Proteins Regulate Spine Morphogenesisand Are Associated with Risk for Schizophrenia2014

    • Author(s)
      Nakazawa T, Hashimoto R, Tanimura A, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M
    • Organizer
      ACNP 53rd Annual Meeting
    • Place of Presentation
      Phoenix, AZ , USA
    • Year and Date
      2014-12-07 – 2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] アメリカにおける神経精神薬理学会の動向2014

    • Author(s)
      橋本均
    • Organizer
      第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会 双方向性トランスレーショナル研究の実現
    • Place of Presentation
      名古屋 名古屋国際会議場
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS細胞関連技術を用いた統合失調症研究2014

    • Author(s)
      中澤敬信、橋本亮太、永安一樹、安田由華、山森英長、梅田知美、藤本美智子、大井一高、石川充、赤松和土、岡野栄之、武田雅俊、橋本均
    • Organizer
      第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会 双方向性トランスレーショナル研究の実現
    • Place of Presentation
      名古屋 名古屋国際会議場
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 自閉症の疾患特異的候補遺伝子の機能的スクリーニング系の確立2014

    • Author(s)
      松村憲佑、永安一樹、中澤敬信、安田由華、山森英長、梅田知美、大井一高、橋本亮太、武田雅俊、橋本均
    • Organizer
      第24回 日本臨床精神神経薬理学会 第44回日本神経精神薬理学会 合同年会 双方向性トランスレーショナル研究の実現
    • Place of Presentation
      名古屋 名古屋国際会議場
    • Year and Date
      2014-11-20 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] LPS誘発炎症モデルにおいて発現変化する脳内miRNAの同定2014

    • Author(s)
      柿原素楽、笠井淳司、岡田遼、尾中勇祐、中澤敬信、永安一樹、早田敦子、新谷紀人、橋本均
    • Organizer
      第126回 日本薬理学会 近畿部会
    • Place of Presentation
      和歌山 和歌山県JAビル
    • Year and Date
      2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] PRABβ(σ)遺伝子欠損マウスの行動表現型に関する検討2014

    • Author(s)
      本郷翔子、中田理恵子、尾中勇祐、新谷紀人、橋本均、井上裕康
    • Organizer
      第87回日本生化学会
    • Place of Presentation
      京都 京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経ペプチドPACAPによる精神機能調節:創薬への展望2014

    • Author(s)
      橋本均、新谷紀人、早田敦子、笠井淳司、永安一樹、中澤敬信
    • Organizer
      第36回日本生物学的精神医学会 第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良 奈良県文化会館
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 精神・神経疾患モデル動物の病態解析のための三次元全脳形態計測法の構築2014

    • Author(s)
      勢力薫、笠井淳司、丹生光咲、早田敦子、永安一樹、中澤敬信、新谷紀人、橋本岳、橋本均
    • Organizer
      第36回日本生物学的精神医学会 第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良 奈良県文化会館
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] A crosstalk between PACAP and serotonin 2A signaling2014

    • Author(s)
      森口 啓太、早田 敦子、道添 瞳、円丁 直樹、新谷 紀人、馬場 明道、橋本 均
    • Organizer
      20th International Symposium on Regulatory Peptides (REGPEG2014)
    • Place of Presentation
      京都 京都ガーデンパレス
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミトコンドリア融合抑制因子MIFIの転写を調節する化合物の探索2014

    • Author(s)
      廣内大成、井上直紀、新谷紀人、田中翔太、笠井淳司、馬場明道、橋本均
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム2014
    • Place of Presentation
      大阪 近畿大学薬学部 東大阪キャンパス
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] コルチコステロン誘発性うつ病モデルを用いたプロスタノイド受容体DP2を介する情動制御機構の解析2014

    • Author(s)
      尾中勇祐、新谷紀人、木野村元彦、平井博之、長田欽也、中村正孝、早田敦子、笠井淳司、永安一樹、中澤敬信、馬場明道、橋本均
    • Organizer
      生体機能と創薬シンポジウム2014
    • Place of Presentation
      大阪 近畿大学薬学部 東大阪キャンパス
    • Year and Date
      2014-08-28 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞内タンパク質輸送と統合失調症2014

    • Author(s)
      中澤敬信、橋本亮太、橋本均
    • Organizer
      生体機能と創薬シンポジウム2014
    • Place of Presentation
      大阪 近畿大学薬学部 東大阪キャンパス
    • Year and Date
      2014-08-28 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳内miRNA発現の高感度検出に向けたin situ hybridization法の最適化:炎症により発現変化する脳内miRNAの同定2014

    • Author(s)
      柿原素楽、笠井淳司、岡田遼、狭間啓佑、中澤敬信、永安一樹、早田敦子、新谷紀人、橋本均
    • Organizer
      生体機能と創薬シンポジウム2014
    • Place of Presentation
      大阪 近畿大学薬学部 東大阪キャンパス
    • Year and Date
      2014-08-28 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] PACAP-PAC1 signaling pathway regulates internalization of serotonin 2A receptor in a PKC and.b-arrestin2 dependent manner2014

    • Author(s)
      早田 敦子、森口 啓太、円丁 直樹、新谷 紀人、馬場 明道、橋本 均
    • Organizer
      29th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2014-06-22 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミトコンドリア融合阻害因子MIFIによる心病態の増悪機序に関する解析:遺伝子発現プロフィール解析2014

    • Author(s)
      田中翔太、新谷紀人、中山博之、東信太朗、開菜摘、舎川洸太、藤尾慈、井上直紀、笠井淳司、早田敦子、橋本均、馬場明道
    • Organizer
      第125回 日本薬理学会 近畿部会
    • Place of Presentation
      岡山 岡山コンベンションセンター
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Remarks] 大阪大学大学院 薬学研究科 神経薬理学分野

    • URL

      http://molpharm.umin.jp/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report 2015 Annual Research Report
  • [Remarks] 大阪大学大学院 薬学研究科 神経薬理学教室

    • URL

      http://molpharm.umin.jp/index.html

    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-16  

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