Search for lead-compounds for new antitumor drug development from alkaloids in medicinal plant reources
| Project/Area Number |
26293023
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Chiba University |
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Principal Investigator |
KITAJIMA Mariko 千葉大学, 大学院薬学研究院, 准教授 (60195261)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 天然活性物質 / 生物活性物質の探索 / 天然物 / 全合成 / 構造解析 / プロドラッグ / アルカロイド / 天然物化学 / 化学合成 |
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| Outline of Final Research Achievements |
To develop highly tumor-selective colchicine derivatives, 4-chlorocolchicine-derived prodrug compound was designed and synthesized. Its cytotoxic activity toward human cancer cell lines was evaluated and the formation of nanoparticles was investigated. Asymmetric total syntheses of alkaloids including Kopsia and Gelsemium alkaloids were accomplished. Several indole alkaloids with novel structure were isolated from Kopsia plants. Vincamine-type alkaloids showed cytotoxic activity toward human cancer cell lines.
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Report
(4 results)
Research Products
(68 results)
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[Presentation] キョウチクトウ科植物Kopsia arborea含有新規インドールアルカロイドKopsiyunnanines E, I, J1, J22014
Author(s)
村上洋介, 小山徹也, 鈴木悠太, 高橋伸明, Yuqui Wu , 小暮紀行, Rongping Zhang, 北島満里子, 高山廣光
Organizer
第56回天然有機化合物討論会
Place of Presentation
高知県立県民文化ホール（高知）
Year and Date
2014-10-15
Related Report
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