| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In order to elucidate the physiological functions of transporters expressing specifically in the blood brain barrier in the brain, in vitro transporter study, and in vivo pharmacokinetic and metabolome analysis in gene knockout mice were conducted. In addition to clarifying the substrate and inhibitor specificities of SLC35F2 in vitro screening using over expression system, changes in the concentrations of drugs and/or endogenous compounds in the brain and urine (urinary excretion) were observed in the knockout mice, suggesting that SLC35F2 is involved in the membrane transport of these compounds.
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