Elucidation of the importance of novel transporters in the disposition of cationic drugs
| Project/Area Number |
26293032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 有機カチオン / トランスポーター / 薬物動態 / 血液脳関門 / 薬物輸送 / メタボローム解析 / 薬物トランスポーター / 腎排泄 / メタボロミクス解析 / 薬物動態学 / 薬物 / 組織移行性 / デリバリー / 体内動態 / カチオン性薬物 |
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| Outline of Final Research Achievements |
In order to elucidate the physiological functions of transporters expressing specifically in the blood brain barrier in the brain, in vitro transporter study, and in vivo pharmacokinetic and metabolome analysis in gene knockout mice were conducted. In addition to clarifying the substrate and inhibitor specificities of SLC35F2 in vitro screening using over expression system, changes in the concentrations of drugs and/or endogenous compounds in the brain and urine (urinary excretion) were observed in the knockout mice, suggesting that SLC35F2 is involved in the membrane transport of these compounds.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Different involvement of OAT in renal disposition of oral anticoagulants rivaroxaban, dabigatran and apixaban2017
Author(s)
Tsuruya Y, Nakanishi T, Komori H, Wang X, Ishiguro N, Kito T, Ikukawa K, Kishimoto W, Ito S, Schaefer O, Ebner T, Yamamura N, Kusuhara H, Tamai I
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Journal Title
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.2015
Author(s)
Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J.
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Journal Title
Drug Metab Dispos
Volume: 43
Issue: 7
Pages: 1008-18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice.2015
Author(s)
Kato K, Moriyama C, Ito N, Zhang X, Hachiuma K, Hagima N, Iwata K, Yamaguchi JI, Maeda K, Ito K, Suzuki H, Sugiyama Y, Kusuhara H.
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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