| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Mechanisms underlying drug-induced pulmonary injury were investigated from the viewpoint of epithelial-mesenchymal transition (EMT) of alveolar epithelial cells deeply related to pulmonary fibrosis. We have found that (1) drugs such as methotrexate act directly on alveolar epithelial cells to cause EMT, (2) various factors such as Smad2 phosphorylation, extracellular secretion factor, and microRNA are involved in the induction of EMT by drugs, (3) quercetin which is used as a supplement in Japan has been shown to have EMT inhibitory effect. These findings would be useful for understanding the molecular mechanisms of drug-induced lung injury and developing strategies for preventing pulmonary disorders.
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