Studies on the regulatory mechanisms for water / salt appetite
Project/Area Number |
26293043
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
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Research Institution | National Institute for Basic Biology |
Principal Investigator |
Hiyama Takeshi 基礎生物学研究所, 統合神経生物学研究部門, 助教 (90360338)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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Keywords | 生理学 / 循環器・高血圧 / 行動学 / 生物物理 / 脳・神経 / 神経疾患 / イオンチャネル / 体液 |
Outline of Final Research Achievements |
In this research project, we investigated neural mechanisms underlying thirst and salt appetite. We identified neurons driving thirst and salt appetite in the subfornical organ and named them water neurons and salt neurons, respectively. Our results show that they are distinct groups of angiotensin II receptor type 1a-positive excitatory neurons. Water neurons were suppressed by cholecystokinin via GABAergic inhibitory neurons. On the other hand, salt neurons were suppressed by another GABAergic population, which are downstream of the glial Na+-level sensor (Nax) in the brain. In addition, Nax is also involved in thirst control: The Na+ signals generated in Nax-positive cells lead to the activation of TRPV4-positive neurons by using epoxyeicosatrienoic acids as gliotransmitters, and stimulated water intake. Finally, our data indicate that the generation of antoantibodies targeting the subfornical organ elicit adipsic hypernatremia without structural anomalies in the hypothalamus.
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] Adipsic Hypernatremia without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ.2017
Author(s)
Hiyama TY, Utsunomiya AN, Matsumoto M, Fujikawa A, Lin CH, Hara K, Kagawa R, Okada S, Kobayashi M, Mayumi I, Anzo M, Cho H, Takayasu S, Nigawara T, Daimon M, Sato T, Terui K, Ito E, Noda M.
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Journal Title
Brain Pathol.
Volume: 27
Issue: 3
Pages: 323-331
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Involvement of Nax sodium channel in peripheral nerve regeneration via lactate signaling.2013
Author(s)
Unezaki, S., Katano, T., Hiyama, T.Y., Nguyen, H. T., Yoshii, S., Noda, M., and Ito, S.
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Journal Title
European Journal of Neuroscience
Volume: 39
Issue: 5
Pages: 720-729
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 体液調節機構のメカニズム2016
Author(s)
檜山武史
Organizer
天然薬物研究方法論アカデミー第19回シンポジウム
Place of Presentation
岡崎コンファレンスセンター(愛知県岡崎市)
Year and Date
2016-10-14
Related Report
Invited
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