Regulatory mechanism of REM sleep by using manipulation of activity and fate of melanin concentrating hormone producinf neurons

• Project/Area Number: 26293046
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Nagoya University
• Principal Investigator: Yamanaka Akihiro 名古屋大学, 環境医学研究所, 教授 (60323292)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000); Fiscal Year 2016: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2015: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 睡眠覚醒 / 視床下部 / メラニン凝集ホルモン / 遺伝子改変 / 光遺伝学 / ノンレム睡眠 / レム睡眠 / 運命制御 / 記憶 / 新奇物体認識試験 / 断眠 / 時期特異的脱落 / 神経活動操作 / 摂食行動 / 飲水行動 / 自発活動 / 遺伝子改変マウス / アデノ随伴ウイルス / 薬理遺伝学

Outline of Final Research Achievements

Activity of MCH neurons were manipulated by optogenetics. Sleep/wakefulness analysis during manipulation of MCH neurons revealed its role in the regulation of sleep/wakefulness. Activation of MCH neurons increased total time in REM sleep to three-hold. However, time in wakefulness was not affected. These results suggest that MCH neurons play role in the regulation of sleep/wakefulness, especially in the transition of non-REM sleep and REM sleep.

Research Products

• [Int'l Joint Research] University of Strathclyde(英国)
• [Int'l Joint Research] SRI International(米国)
• [Journal Article] Muscular mechanical hyperalgesia after lengthening contractions in rats depends on stretch velocity and range of motion. (2017)
  • Author(s): Hayashi K, Katanosaka K, Abe M, Yamanaka A, Nosaka K, Mizumura K, *Taguchi T
  • Journal Title: Eur J Pain Volume: 21 Issue: 1 Pages: 125-139
  • DOI: 10.1002/ejp.909
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lateral hypothalamic circuits for sleep-wake control. (2017)
  • Author(s): Yamashita T, * Yamanaka A
  • Journal Title: Curr Opin Neurobiol Volume: 44 Pages: 94-100
  • Acknowledgement Compliant
• [Journal Article] Top-down cortical input during nrem sleep consolidates perceptual memory. (2016)
  • Author(s): Miyamoto D, Hirai D, Fung CC, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, *Murayama M
  • Journal Title: Science Volume: 352 Issue: 6291 Pages: 1315-1318
  • DOI: 10.1126/science.aaf0902
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation. (2016)
  • Author(s): Inutsuka A, Yamashita A, Chowdhury S, Nakai J, Ohkura M, Taguchi T, Yamanaka A
  • Journal Title: Scientific Reports Volume: 6:29480 Issue: 1 Pages: 1-15
  • DOI: 10.1038/srep29480
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Direct projections from hypothalamic orexin neurons to brainstem cardiac vagal neurons. (2016)
  • Author(s): Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D
  • Journal Title: Neuroscience Volume: 339 Pages: 47-53
  • DOI: 10.1016/j.neuroscience.2016.09.038
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hypoxia and hypercapnia inhibit hypothalamic orexin neurons in rats. (2016)
  • Author(s): Dergacheva O, Yamanaka A, Schwartz AR, Polotsky VY, Mendelowitz D
  • Journal Title: J Neurophysiol Volume: 116 Issue: 5 Pages: 2250-2259
  • DOI: 10.1152/jn.00196.2016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Optogenetic activation of serotonergic terminals facilitates gabaergic inhibitory input to orexin/hypocretin neurons. (2016)
  • Author(s): Chowdhury S, *Yamanaka A
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 36039-36039
  • DOI: 10.1038/srep36039
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with gi-dreadd in mice. (2016)
  • Author(s): Wakaizumi K, Kondo T, Hamada Y, Narita M, Kawabe R, Narita H, Watanabe M, Kato S, Senba E, Kobayashi K, Kuzumaki N, Yamanaka A, Morisaki H, *Narita M
  • Journal Title: Mol Pain Volume: 12 Pages: 1-11
  • DOI: 10.1177/1744806916681567
  • Peer Reviewed / Open Access
• [Journal Article] Progressive loss of the orexin neurons reveals dual effects on wakefulness (2016)
  • Author(s): Branch, A. F., Navidi, W., Tabuchi, S., Terao, A., Yamanaka, A., Scammell, T. E., and Behn, C. D.
  • Journal Title: Sleep Volume: 39 Issue: 2 Pages: 369-377
  • DOI: 10.5665/sleep.5446
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A top-down cortical circuit for accurate sensory perception (2015)
  • Author(s): Manita S, Suzuki T, Homma C, Matsumoto T, Odagawa M, Yamada K, Ota K, Matsubara C, Inutsuka A, Sato M, Ohkura M, Yamanaka A, Yanagawa Y, Nakai J, Hayashi Y, Larkum ME, Murayama M
  • Journal Title: Neuron Volume: 86(5) Issue: 5 Pages: 1304-16
  • DOI: 10.1016/j.neuron.2015.05.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Atomistic design of microbial opsin-based blue-shifted optogenetics tools (2015)
  • Author(s): Kato HE, Kamiya M, Sugo S, Ito J, Taniguchi R, Orito A, Hirata K, Inutsuka A,Yamanaka A, Maturana AD, Ishitani R, Sudo Y, Hayashi S, Nureki O
  • Journal Title: Nat Commun Volume: 6 Issue: 1 Pages: 7177-7177
  • DOI: 10.1038/ncomms8177
  • NAID: 120005745621
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Insular neural system controls decision-making in healthy and methamphetamine-treated rats (2015)
  • Author(s): Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Nakamura A, Wang T, Nagai T, Sato J, Sawada M, Ohira H,Yamanaka A, Yamada K
  • Journal Title: Proc Natl Acad Sci U S A Volume: 112 (29) Issue: 29 Pages: 3930-3939
  • DOI: 10.1073/pnas.1418014112
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior. (2015)
  • Author(s): Shibasaki K, Sugio S, Takao K, Yamanaka A, Miyakawa T, Tominaga M, Ishizaki Y
  • Journal Title: Pflugers Arch Volume: 467 (12) Issue: 12 Pages: 2495-2507
  • DOI: 10.1007/s00424-015-1726-0
  • Peer Reviewed / Open Access
• [Journal Article] Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits (2015)
  • Author(s): Kazuhiro Ishii, Ken-ichiro Kubo, Toshihiro Endo, Keitaro Yoshida, Seico Benner, Yukiko Ito, Hidenori Aizawa, Michihiko Aramaki, Akihiro Yamanaka, Kohichi Tanaka, Norio Takata, Kenji Tanaka, Masaru Mimura, Chiahru Tohyama, Masaki Kakeyama, and Kazunori Nakajima
  • Journal Title: Journal of Neuroscience Volume: 35 Issue: 36 Pages: 12432-45
  • DOI: 10.1523/jneurosci.3648-14.2015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Near-infrared (NIR) up-conversion optogenetics. (2015)
  • Author(s): Shoko Hososhima, Hideya Yuasa, Toru Ishizuka, Mohammad R. Hoque, Takayuki Yamashita, Akihiro Yamanaka, Eriko Sugano, Hiroshi Tomita, and Hiromu Yawo
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 16533-16533
  • DOI: 10.1038/srep16533
  • NAID: 120007179836
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Challenges in the development of therapeutics for narcolepsy (2015)
  • Author(s): Black SW, Yamanaka A, Kilduff TS
  • Journal Title: Prog Neurobiol Volume: 印刷中 Pages: 89-113
  • DOI: 10.1016/j.pneurobio.2015.12.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] How genetically engineered systems are helping to define, and in some cases redefine, the neurobiological basis of sleep and wake (2015)
  • Author(s): Fuller PM, Yamanaka A, Lazarus M
  • Journal Title: Temperature Volume: 2 (3) Issue: 3 Pages: 406-417
  • DOI: 10.1080/23328940.2015.1075095
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. (2014)
  • Author(s): Takayama Y, Shibasaki K, Suzuki Y, Yamanaka A, Tominaga M
  • Journal Title: FASEB J Volume: 28 Issue: 5 Pages: 2238-2248
  • DOI: 10.1096/fj.13-243436
  • Peer Reviewed / Open Access
• [Journal Article] GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy. (2014)
  • Author(s): Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS
  • Journal Title: J Neurosci Volume: 34 Issue: 19 Pages: 6485-6494
  • DOI: 10.1523/jneurosci.0080-14.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Conditional ablation of orexin/hypocretin neurons : A new mouse model for the study of narcolepsy and orexin system function. (2014)
  • Author(s): Tabuchi S, Tsunematsu T, Black SW, Tominaga M, Maruyama M, Takagi K, Minokoshi Y, Sakurai T, Kilduff TS, Yamanaka A
  • Journal Title: The Joumal of Neuroscience Volume: (in press) Issue: 19 Pages: 6495-6509
  • DOI: 10.1523/jneurosci.0073-14.2014
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic manipulation of activity and temporally controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation. (2014)
  • Author(s): Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A.
  • Journal Title: Journal of Neuroscience Volume: 34 Issue: 20 Pages: 6896-6909
  • DOI: 10.1523/jneurosci.5344-13.2014
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards. (2014)
  • Author(s): Miyazaki KW, Miyazaki K, Tanaka KF, Yamanaka A, Takahashi A, Tabuchi S, Doya K
  • Journal Title: Curr Biol Volume: 24 Issue: 17 Pages: 2033-2040
  • DOI: 10.1016/j.cub.2014.07.041
  • Peer Reviewed / Open Access
• [Journal Article] Concurrent and robust regulation of feeding behavions and metabolism by orexin neurons. (2014)
  • Author(s): Inutsuka A, Inui A, Tabuchi S, Tsunematsu T, Lazarus M.
  • Journal Title: Neuropharmacology Volume: 85 Pages: 451-460
  • DOI: 10.1016/j.neuropharm.2014.06.015
  • Peer Reviewed / Open Access
• [Journal Article] Optogenetic activation of serotonergic neurons enhances anxiety-like behavior in mice. (2014)
  • Author(s): Ohmura Y, Tanaka KF, Tsunematsu T, Yamanaka A,Yoshioka M
  • Journal Title: Int J Neuropsychopharmacology Volume: 17 Issue: 11 Pages: 1777-1783
  • DOI: 10.1017/s1461145714000637
  • Peer Reviewed / Open Access
• [Presentation] 視床下部神経細胞の活動記録と活動操作 (2017)
  • Author(s): 山中章弘
  • Organizer: 第90回日本薬理学会年会 シンポジウム 25 脳神経疾患のセルアセンブリ解析と神経活動制御研究の最先端
  • Place of Presentation: 長崎ブリックホール、長崎新聞文化ホール
  • Year and Date: 2017-03-15
  • Invited
• [Presentation] 視床下部神経による睡眠と記憶の制御 (2017)
  • Author(s): 山中章弘
  • Organizer: 神戸大学医学研究科薬理学分野講演会
  • Place of Presentation: 神戸大学医学研究科
  • Invited
• [Presentation] 視床下部神経による睡眠覚醒と記憶の制御 (2017)
  • Author(s): 山中章弘
  • Organizer: 都医学研セミナー
  • Place of Presentation: 東京都医学総合研究所
  • Invited
• [Presentation] 睡眠障害モデルマウス作成と機能解析 (2017)
  • Author(s): 山中章弘
  • Organizer: 都医学研プロジェクトセミナー
  • Place of Presentation: 東京都医学総合研究所
  • Invited
• [Presentation] 光遺伝学・薬理遺伝学を用いた神経活動操作による睡眠覚醒制御と記憶制御 (2017)
  • Author(s): 山中章弘
  • Organizer: 新潟脳神経研究会特別例会
  • Place of Presentation: 新潟大学脳研究所
  • Invited
• [Presentation] 視床下部神経による睡眠覚醒調節のメカニズム (2017)
  • Author(s): 山中章弘
  • Organizer: 第78回原研研究集会
  • Place of Presentation: 長崎大学
  • Invited
• [Presentation] 視床下部神経活動の記録と操作による睡眠覚醒と記憶の制御機構の解明 (2017)
  • Author(s): 山中章弘
  • Organizer: 第94回日本生理学会大会 シンポジウム：in vivo生理学：その観察と操作
  • Place of Presentation: アクトシティ浜松
  • Invited
• [Presentation] Hypothalamic melanin concentrating hormone (MCH) neurons inhibiting memory formation during sleep. (2016)
  • Author(s): Yamanaka A
  • Organizer: Neuroscience 2016 Satellite Meeting "Wiring and Functional Principles of Neural Circuits"
  • Place of Presentation: San Diego, California, U.S.A
  • Year and Date: 2016-11-17
  • Int'l Joint Research / Invited
• [Presentation] 視床下部神経細胞による睡眠覚醒、睡眠関連機能の調節メカニズム (2016)
  • Author(s): 山中章弘
  • Organizer: 第23回日本時間生物学会学術大会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2016-11-12
  • Invited
• [Presentation] Hypothalamic peptidergic neurons regulates sleep/wakefulness and memory. (2016)
  • Author(s): Izawa S, Inoue R, Mukai Y, Terao A, Chowdhury S, Mizoguchi H, Yamanaka A
  • Organizer: 23rd Congress of the European Sleep Research Society (ESRS) 2016
  • Place of Presentation: Bologna, Italy
  • Year and Date: 2016-09-13
  • Int'l Joint Research
• [Presentation] オレキシン神経による鎮痛作用 (2016)
  • Author(s): 犬束 歩, 山下 哲, スリカント チョドリ, 田口 徹, 山中章弘
  • Organizer: 第 36回鎮痛薬・オピイドペプチシンポジウム
  • Place of Presentation: 北海道大学
  • Year and Date: 2016-08-19
  • Invited
• [Presentation] ファイバーレス光遺伝学開発と睡眠覚醒・記憶操作への応用. (2016)
  • Author(s): 山中章弘
  • Organizer: ルミノジェネティクス研究会
  • Place of Presentation: KKRホテル熱海
  • Year and Date: 2016-07-23
  • Invited
• [Presentation] ファイバーフォトメトリを用いた視床下部オレキシン神経活動の記録 (2016)
  • Author(s): 山中章弘, 犬束 歩, 山下 哲, 田口 徹
  • Organizer: 第39回日本神経科学大会 シンポジウム「ファイバーフォトメトリを用いた行動中動物の脳深部神経活動記録」
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-07-20
  • Invited
• [Presentation] The role of hypothalamic peptidergic neurons in the regulation of brain states. (2016)
  • Author(s): Yamanaka A
  • Organizer: 10th FENS Forum of Neuroscience 2016
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2016-07-02
  • Int'l Joint Research / Invited
• [Presentation] 光遺伝学、薬理遺伝学を用いた睡眠覚醒調節メカニズムの解明 (2016)
  • Author(s): 山中章弘
  • Organizer: 2015年度第2回バイオ単分子研究会
  • Place of Presentation: いわき
  • Year and Date: 2016-03-30
  • Invited
• [Presentation] 視床下部神経細胞による睡眠覚醒調節と記憶の制御 (2016)
  • Author(s): 山中章弘
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-26
  • Invited
• [Presentation] 視床下部ペプチド作動性神経細胞による睡眠覚醒と記憶の制御 (2016)
  • Author(s): 山中章弘
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-22
  • Invited
• [Presentation] オレキシン神経の活動操作と運命制御による痛み知覚における役割 (2016)
  • Author(s): 山中章弘、犬束 歩、山下 哲
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2016-03-09
  • Invited
• [Presentation] 睡眠覚醒調節と睡眠関連脳機能の制御メカニズムについて (2016)
  • Author(s): 山中章弘
  • Organizer: 千里ライフサイエンスセミナー J5： 光遺伝学による脳・生物学研究最前線
  • Place of Presentation: 豊中
  • Year and Date: 2016-02-26
  • Invited
• [Presentation] MCH neurons regulates sleep/wakefulness and memory (2016)
  • Author(s): 山中章弘
  • Organizer: 大脳新皮質構築終了国際シンポジウム「Neocortical Organization III」
  • Place of Presentation: 東京
  • Year and Date: 2016-02-11
  • Int'l Joint Research / Invited
• [Presentation] オレキシンとは？睡眠覚醒調節における役割について (2016)
  • Author(s): 山中章弘
  • Organizer: 長岡不眠症フォーラム
  • Place of Presentation: ホテルニューオータニ長岡
  • Invited
• [Presentation] 視床下部神経による睡眠覚醒と記憶の制御メカニズム (2016)
  • Author(s): 山中章弘
  • Organizer: 広島大学インキュベーション研究拠点「本能行動の発現メカニズムに関する総合科学研究推進拠点－大学生の生活習慣及び科学リテラシーの確立へ向けて－」
  • Place of Presentation: 広島大学
  • Invited
• [Presentation] 本能行動調節を目指す創薬・医療薬理 (2016)
  • Author(s): 山中章弘, 犬束 歩, 山下 哲, 田口 徹
  • Organizer: 次世代を担う創薬・医療薬理シンポジウム 2016
  • Place of Presentation: 東北大学
  • Invited
• [Presentation] オレキシン受容体拮抗薬とベンゾ系・非ベンゾ系薬との作用メカニズムの違いについて (2016)
  • Author(s): 山中章弘
  • Organizer: 高齢者不眠症セミナー
  • Place of Presentation: 名古屋観光ホテル
  • Invited
• [Presentation] Hypothalamic neurons regulate sleep/wakefulness and memory. (2016)
  • Author(s): Yamanaka A
  • Organizer: CNS Collaborators Day 2016 "Emerging Techniques"
  • Place of Presentation: Adelaide, Australia
  • Int'l Joint Research / Invited
• [Presentation] 様々な神経活動操作法による生理機能の解明. (2016)
  • Author(s): 山中章弘
  • Organizer: 第10回骨・軟骨フロンティア
  • Place of Presentation: ベルサール八重洲
  • Invited
• [Presentation] 社会性に関わる神経への入力経路同定と回路機能解析 (2016)
  • Author(s): 山中章弘
  • Organizer: 平成28年度生理研研究会・第6回社会神経科学研究会「社会の成り立ちを支える内分泌学」
  • Place of Presentation: 生理学研究所
  • Invited
• [Presentation] Good Sleep: Relief from Sleep Disorder (2016)
  • Author(s): Yamanaka A
  • Organizer: Fifteenth Japanese-American Kavli Frontiers of Science Symposium
  • Place of Presentation: Irvine, California, U.S.A.
  • Int'l Joint Research / Invited
• [Presentation] 神経ペプチドによる睡眠と記憶の制御 (2016)
  • Author(s): 山中章弘
  • Organizer: 第2回名古屋大学－ラクオリア創薬 創薬シンポジウム
  • Place of Presentation: 名古屋大学医学部
  • Invited
• [Presentation] Hypothalamic neurons regulate sleep/wakefulness and memory. (2016)
  • Author(s): Yamanaka A
  • Organizer: The 5th Annual IIIS Symposium
  • Place of Presentation: Tokyo Conference Center Shinagawa
  • Int'l Joint Research / Invited
• [Presentation] Hypothalamic peptidergic neurons regulates sleep/wakefulness and memory (2015)
  • Author(s): 山中章弘
  • Organizer: International Symposium Optogenetics 2015
  • Place of Presentation: 東京
  • Year and Date: 2015-12-04
  • Int'l Joint Research / Invited
• [Presentation] 光遺伝学、薬理遺伝学を用いた神経活動操作と講堂制御 (2015)
  • Author(s): 山中章弘
  • Organizer: 医用光学・分光学系合同研究会 Medical Optics & Spectoscopy 2016
  • Place of Presentation: 宮崎
  • Year and Date: 2015-11-12
  • Invited
• [Presentation] 遺伝学、薬理遺伝学を用いた青斑核ノルアドレナリン神経活動操作と自律機能 (2015)
  • Author(s): 山中章弘
  • Organizer: 第68回日本自立神経学会総会 シンポジウム5： 自律神経の中枢制御
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] オレキシンとは？ 睡眠覚醒調節における役割について (2015)
  • Author(s): 山中章弘
  • Organizer: 第42回日本脳科学会ランチョンセミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] 視床下部神経による睡眠覚醒調節と記憶の制御 (2015)
  • Author(s): 山中章弘
  • Organizer: 比較記憶研究会「異なる動物種間での記憶回路制御機構の統合的理解による記憶回路原理の解明」
  • Place of Presentation: 岡崎
  • Year and Date: 2015-10-08
  • Invited
• [Presentation] 丸ごと動物を用いた特定神経の活動操作と活動記録 (2015)
  • Author(s): 山中章弘、犬束 歩、山下 哲
  • Organizer: 第42回日本神経内分泌学会
  • Place of Presentation: 仙台
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] 睡眠と記憶の調節に関わる視床下部神経の役割 (2015)
  • Author(s): 山中章弘、常松友美、伊澤俊太郎、上野貴文、大村 優、寺尾 晶
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
  • Invited
• [Presentation] How does the brain regulate sleep/wakefulness? (2015)
  • Author(s): 山中章弘
  • Organizer: RIKEN BSI Summer Program Lecture Course
  • Place of Presentation: 和光
  • Year and Date: 2015-07-20
  • Invited
• [Presentation] 神経活動操作と運命制御を用いた睡眠関連機能の解析 (2015)
  • Author(s): 山中章弘、犬束 歩、山下 哲
  • Organizer: 日本睡眠学会第40回定期学術集会
  • Place of Presentation: 宇都宮
  • Year and Date: 2015-07-02
  • Invited
• [Presentation] Manipulation of specific neurons using optogenetics or pharmacogenetics (2015)
  • Author(s): 山中章弘
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
  • Invited
• [Presentation] Study of neuroendocrine system in hypothalamus using optogenetics and pharma (2015)
  • Author(s): 山中章弘
  • Organizer: Seoul International Congress of Endocrinology and Metabolism
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-04-30
  • Int'l Joint Research / Invited
• [Presentation] 光遺伝学、薬理遺伝学を用いた内分泌研究 (2015)
  • Author(s): 山中章弘、犬束 歩、常松友美、山下 哲
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-23
  • Invited
• [Presentation] リズムと本能行動調節のメカニズム (2015)
  • Author(s): 山中章弘
  • Organizer: 第92回日本生理学会大会 シンポジウム：流れる時と繰り返す時間の解剖生理学
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-22
  • Invited
• [Presentation] オレキシンの基礎的なメカニズム (2015)
  • Author(s): 山中章弘
  • Organizer: 第88回日本薬理学会年会 ランチョンセミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-19
  • Invited
• [Presentation] 特定神経活動操作による神経回路機能の解明 (2015)
  • Author(s): 山中章弘、犬束 歩、山下 哲
  • Organizer: 第88回日本薬理学会年会 シンポジウム「特定細胞ネットワーク活性制御システムの脳機能／脳疾患解析への応用：脳細胞のシングルセルアナリシスへの挑戦」
  • Place of Presentation: 名古屋
  • Year and Date: 2015-03-18
  • Invited
• [Presentation] Development of new tools for multiple selected gene expression control for specific neural pathway labeling in vivo using trans synaptic Cre recombinase. (2015)
  • Author(s): Yamanaka A
  • Organizer: SRI International Seminar
  • Place of Presentation: Menlo Park, CA, U.S.A.
  • Year and Date: 2015-02-13
  • Invited
• [Presentation] 光遺伝学を用いた精神神経薬理研究 (2014)
  • Author(s): 山中章弘
  • Organizer: 第44回日本神経精神薬理学会 教育セミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] Regulatory mechanism of sleep/wakefulness revealed by using optogenetics. (2014)
  • Author(s): Yamanaka A
  • Organizer: 16th International Conference on Retinal Proteins
  • Place of Presentation: Nagahama, Japan
  • Year and Date: 2014-10-09
  • Invited
• [Presentation] Neural regulatory mechanism of state transitions: wakefulness, non-REM and REM sleep. (2014)
  • Author(s): 山中章弘
  • Organizer: 藤原セミナー
  • Place of Presentation: 伊豆
  • Year and Date: 2014-09-27
  • Invited
• [Presentation] 覚醒ーノンレム睡眠ーレム睡眠調節における視床下部メラニン凝集ホルモン産生神経の役割 (2014)
  • Author(s): 山中章弘、犬束 歩、常松 友美
  • Organizer: 第37回日本神経科学大会 シンポジウム 光遺伝学や科学遺伝学を用いた神経回路機能操作と行動制御
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-12
  • Invited
• [Presentation] Orexin/hypocretin and its physiological roles. (2014)
  • Author(s): Yamanaka A
  • Organizer: 5th International Symposium on the Physiology and Pharmacology of Temperature Regulation (PPTR)
  • Place of Presentation: Skukuza, South Africa
  • Year and Date: 2014-09-09
  • Invited
• [Presentation] Activity control or fate control of melanin concentrating hormone (MCH)-containing neurons. (2014)
  • Author(s): Yamanaka A, Tsunematsu T, Inutsuka A
  • Organizer: Korean Association for Laboratory Animal Science 2014 International Symposium
  • Place of Presentation: Yeosu, Korea
  • Year and Date: 2014-08-21
  • Invited
• [Presentation] Behavior control by activity manipulatino of hypothalamic neurons using optogenetics. (2014)
  • Author(s): Yamanaka A
  • Organizer: University of Strathclyde Seminar
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2014-07-23
  • Invited
• [Presentation] Manipulation of neural activity and behavior control. (2014)
  • Author(s): 山中章弘
  • Organizer: 第37回内藤コンファレンス
  • Place of Presentation: ニセコ
  • Year and Date: 2014-07-16
  • Invited
• [Presentation] 睡眠覚醒調節におけるオレキシン神経の役割 (2014)
  • Author(s): 山中章弘
  • Organizer: 日本睡眠学会第39回定期学術集会 シンポジウム：オレキシンの基礎から臨床
  • Place of Presentation: 徳島
  • Year and Date: 2014-07-04
  • Invited
• [Presentation] Behavior Control by Activity Manipulation of Hypothalamic Neurons Using Optogenetics. (2014)
  • Author(s): Yamanaka A
  • Organizer: iCeMS International Symposium
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2014-06-13
  • Invited
• [Book] 睡眠科学 最新の基礎研究から医療・社会への応用まで (2016)
  • Author(s): 山中章弘
  • Publisher: 化学同人
• [Book] コメディカル専門基礎科目シリーズ 生理学 (2016)
  • Author(s): 山中章弘、田淵紗和子
  • Publisher: 理工図書
• [Book] 光と生命の事典 (分担執筆） (2016)
  • Author(s): 山中章弘
  • Total Pages: 420
  • Publisher: 朝倉書店
• [Book] 分子脳科学 分子から脳機能と心に迫る (分担執筆） (2015)
  • Author(s): 犬束歩、山中章弘
  • Total Pages: 291
  • Publisher: 化学同人
• [Book] Orexin and Sleep (分担執筆） (2015)
  • Author(s): Yamanaka A, Tsunematsu T
  • Total Pages: 410
  • Publisher: Springer
• [Book] Optogenetics: Light-Sensing Proteins and Their Applications (分担執筆） (2015)
  • Author(s): Yamanaka A
  • Total Pages: 409
  • Publisher: Springer Japan
• [Book] Optogenetics: Light-Sensing Proteins and Their Applications (分担執筆） (2015)
  • Author(s): Yamanaka A, Tsunematsu T
  • Total Pages: 409
  • Publisher: Springer Japan
• [Remarks] 環境医学研究所神経系分野２
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/
• [Remarks] 名古屋大学環境医学研究所
  • URL: http://www.riem.nagoya-u.ac.jp/
• [Remarks] 名古屋大学環境医学研究所神経系分野２
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/
• [Remarks] Int J Neuropsychopharmacolに掲載されました
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140523.pdf
• [Remarks] 常松友美の論文がJ Neurosciに掲載されました
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140515.pdf
• [Remarks] 田淵紗和子の論文がJ Neurosciに掲載されました
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140508.pdf
• [Remarks] 山中章弘とSRI Dr. Kilduffとの共同研究がJ Neurosciに掲載されました。
  • URL: http://www.riem.nagoya-u.ac.jp/4/drof1/nr/files/kaisetsu20140508.pdf
• [Remarks] 名古屋大学NU Researchのハイライト論文に掲載されました
  • URL: http://www.aip.nagoya-u.ac.jp/public/nu_research_ja/highlights/detail/0001386.html