| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
In mammals, the circadian clock is cell autonomous and comprised of an autoregulatory transcriptional and translational feedback loop composed of several clock genes and their protein products. A growing body of evidence revealed a close link between the circadian clock and metabolism. In this study, using a mouse model of diet-induced obesity, we revealed that enhancement of circadian clock oscillation renders protection against metabolic syndrome. Daily restricted feeding caused disturbance of circadian transcriptional networks in a tissue specific manner. The genes involved in lipid metabolism were enriched in the differentially expressed genes between daytime and nighttime food restriction, suggesting that they may contribute to obesity.
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